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Simon Bayly

@simonbayly

Reformed chemist πŸ‘¨β€πŸ”¬ IP licensing and spinouts at the Francis Crick Institute. Also post about cycling 🚲 Opinion my own etc.

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Latest posts by Simon Bayly @simonbayly

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10.03.2026 20:23 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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Leader of the Opposition
youraislopbores.me

10.03.2026 20:14 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 1
How a protein pair ensures that faulty mRNA is destroyed Nonsense-mediated mRNA decay (NMD) is one of the most important processes in our cells to ensure that no faulty or incomplete proteins are produced. Scientists have now identified a central mechanism behind this control system.

How a protein pair ensures that faulty mRNA is destroyed

10.03.2026 09:58 πŸ‘ 3 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0

Given everything that Odysseus does, it truly baffles me that β€˜Odyssey’ has become a term for a worthy quest.

10.03.2026 08:57 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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Medicine at the Crick |Β Interfacing the human brain: neurons to networks

This Thursday at @crick.ac.uk www.crick.ac.uk/whats-on/med...

09.03.2026 17:23 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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Albini Sessions (Benefit for Letters Charity), by Fugazi 12 track album

Stop literally everything.

Steve Albini's Fugazi sessions, widely bootlegged and full of lore, now available officially for the first time.

fugazi.bandcamp.com/album/albini...

06.03.2026 14:56 πŸ‘ 1371 πŸ” 503 πŸ’¬ 34 πŸ“Œ 136
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Bluesky map, now with posts read aloud πŸ”ˆ - pretty trippy

bluesky-map.theo.io?live=1&reada...

Chrome recommended. Uses significant bandwidth to download TTS voices.

06.03.2026 17:46 πŸ‘ 32 πŸ” 6 πŸ’¬ 4 πŸ“Œ 2

I'm not smearing faeces on the walls, I'm daubing excrement on the masonry

06.03.2026 17:43 πŸ‘ 2 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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Allosteric PROTACs: Expanding the Horizon of Targeted Protein Degradation Proteolysis-targeting chimeras (PROTACs) have transformed the concept of chemical intervention in biological systems by co-opting the ubiquitin–proteasome system to selectively degrade proteins. A key...

Allosteric PROTACs: Expanding the Horizon of Targeted Protein Degradation

06.03.2026 12:00 πŸ‘ 3 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0
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Self-amplifying RNA improves heart function after myocardial infarction in mice and pigs @science.org @columbiauniversity.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...

05.03.2026 20:44 πŸ‘ 17 πŸ” 7 πŸ’¬ 0 πŸ“Œ 1

Any relation to Paul Seixas?

05.03.2026 20:07 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
Grand Challenges for Predictive Modeling in Small Molecule Drug Discovery | ChemRxiv We present a set of Grand Challenges for predictive modeling in small molecule drug discovery, with the goal of defining, prioritizing, and quantifying the areas where computation can have transformative impact. Rather than offering another broad survey ...

Grand Challenges for Predictive Modeling in Small Molecule Drug Discovery
chemrxiv.org/doi/full/10....
#chemsky

05.03.2026 16:33 πŸ‘ 2 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0

It turns out that I am situated in the uncharted backwaters of the unfashionable end of the Western spiral arm of the Bluesky galaxy

05.03.2026 13:20 πŸ‘ 2 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0

It turns out that I am situated in the uncharted backwaters of the unfashionable end of the Western spiral arm of the Bluesky galaxy

05.03.2026 13:20 πŸ‘ 2 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0

'Jumbo cyanophage' 🐘🦠

04.03.2026 20:47 πŸ‘ 2 πŸ” 1 πŸ’¬ 0 πŸ“Œ 1

Interesting that longstanding tech investor Seedcamp is making its first forays into bio

03.03.2026 10:01 πŸ‘ 0 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
I fucking hate proline so fucking much it's the worst amino acid it's so fucking stupid it's incapable of being fucking normal so it forms an ugly ass ring with itself with its own fucking nitrogen cuz it's a loser fucking amino acid I hate it so much I'd rather cut off my right tit than have to ever draw a mechanism with proline ever again

I fucking hate proline so fucking much it's the worst amino acid it's so fucking stupid it's incapable of being fucking normal so it forms an ugly ass ring with itself with its own fucking nitrogen cuz it's a loser fucking amino acid I hate it so much I'd rather cut off my right tit than have to ever draw a mechanism with proline ever again

Remember that everyone you meet is fighting their own battle, sometimes with amino acids

02.03.2026 00:37 πŸ‘ 266 πŸ” 48 πŸ’¬ 16 πŸ“Œ 7

See also the Conservatives. And current Labour policies are bad even if workable.

03.03.2026 08:06 πŸ‘ 0 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
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Glasgow Uni spin-out raises Β£1.6M for cancer-detecting AI - United Kingdom A spin-out company from the University of Glasgow has secured Β£1.6M seed investment to launch AI technology that is learning β€˜the language of cancer’ to

Glasgow Uni spin-out raises Β£1.6M for cancer-detecting AI

https://www.europesays.com/uk/798893/

A spin-out company from the University of Glasgow has secured Β£1.6M seed investment to launch AI technology that…#uk #news #uknews

02.03.2026 11:40 πŸ‘ 1 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0

Anybody doing proteomics on FACS sorted cells? People are using BSA coated tubes to avoid cell adhesion onto the walls. BSA is all over the protein extract. How to avoid this BSA? Saw Polyvinyl alcohol (PVA) can be used in place of BSA. Any experience with its compatibility for downstream MS? Thanks

02.03.2026 18:31 πŸ‘ 1 πŸ” 1 πŸ’¬ 2 πŸ“Œ 0

Call me a luddite, anti-technology, or whatever, but I still have yet to see a use of AI in the pharmaceutical industry that actually improved the science at the bench level.

#Ichoseviolence
Yes, I am trolling to start my next cull...

02.03.2026 13:10 πŸ‘ 2 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
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Why an industry career move is a taboo topic in academia Adam Levy investigates why researchers are sometimes reluctant to disclose their plans to colleagues.

Is this a genuine headline in the year 2026, or is it clickbait?
www.nature.com/articles/d41...

02.03.2026 12:39 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

Criminal and shameful

01.03.2026 22:55 πŸ‘ 2 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

An interesting way to think of embryo development is like evolution - starting as a tube/worm, becoming fish-like then amphibian-like before losing its tail and turning mammalian

01.03.2026 14:09 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

The stage after blastocyst is called gastrulation

01.03.2026 13:42 πŸ‘ 0 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0

Putting the "LLM" in "Gell-Mann amnesia"

27.02.2026 14:34 πŸ‘ 129 πŸ” 26 πŸ’¬ 2 πŸ“Œ 2

Investors have already responded to Trump 2 by putting more of their money into other parts of the world. The Anthropic case is exactly what they feared. The rule of law does not exist in the US today. No investment is safe under fascism. Hence the avoidance of the US is going to intensify.

28.02.2026 08:29 πŸ‘ 9 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
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Atrium spins out of Avidity, aiming to target rare heart diseases with RNA - Switzerland A newly formed spinout of recently acquired Avidity Biosciences debuted Friday with plans to pick up some of its predecessor’s work.Β 

Atrium spins out of Avidity, aiming to target rare heart diseases with RNA

https://www.europesays.com/ch/21168/

A newly formed spinout of recently acquired Avidity Biosciences debuted Friday with plans to pick up some of…

27.02.2026 23:00 πŸ‘ 1 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
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Behind Generate's 'feverish' race to raise $400M IPO while window remains open Generate:Biomedicines is the latest biotech to benefit from a renewed appetite from investors for publicly listed drug developers. | Generate:Biomedicines is the latest biotech to benefit from a renew...

Has the winter ended for biotech IPOs? www.fiercebiotech.com/biotech/gene...

27.02.2026 18:17 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
IQVIA to Acquire Discovery Services Assets from Charles River Laboratories February 25, 2026 β€” Leads & Copy β€” IQVIA Holdings Inc. (NYSE: IQV) has agreed to acquire certain discovery services assets from Charles River Laboratories, the company announced today. The assets incl...

biotech CRO M&A shenangigans
biotechreporter.news/iqvia-to-acq...

27.02.2026 17:26 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0