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Marieke van Ham

@hammarieke

B cell immunologist focussing on antibody formation and pandemics research, Sanquin Blood Supply and SILS, Faculty of Science, University of Amsterdam, the Netherlands. My texts are on personal title, but data-based.

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01.01.2025
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Latest posts by Marieke van Ham @hammarieke

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Convergent and lineage-specific genomic changes shape adaptations in sugar-consuming birds High-sugar diets cause human metabolic diseases, yet several bird lineages convergently adapted to feeding on sugar-rich nectar or fruits. We investigated the underlying molecular mechanisms in hummin...

In a new Science study, researchers find that some bird species share convergent evolutionary changes in key physiological traits and metabolic genes that enable their high-sugar diets. https://scim.ag/4bgMrpy

12.03.2026 20:50 πŸ‘ 31 πŸ” 11 πŸ’¬ 0 πŸ“Œ 0
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How bumble bees survive days underwater without drowning Insects can stay alive for up to a week in flooded nests, thanks to several tricks

β€œThey’re actually breathing underwater, and that is really exciting and interesting.” https://scim.ag/3OZwj4s

12.03.2026 22:15 πŸ‘ 182 πŸ” 69 πŸ’¬ 0 πŸ“Œ 14
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Lassa fever kills thousands of people in West Africa each year, yet many cases go undiagnosed before it’s too late. A Lancet study suggests the true scale of infection may be far higher than official figures show.

Read why missed diagnostics could raise the risk of wider spread: bit.ly/4rp7JaD

11.03.2026 17:03 πŸ‘ 3 πŸ” 3 πŸ’¬ 1 πŸ“Œ 0

⏳Less than 2 months to #DayofImmunology 2026!

#DoI2026 webinar, social media campaigns & DoI Awards - something for everyone🧬
πŸ’‘Share your plans - Let’s celebrate immunology together on April 29!
πŸ”— loom.ly/yWRSIP0

#RegulatoryTCell

@eurjimmunol.bsky.social @yefis-immunology.bsky.social

06.03.2026 13:19 πŸ‘ 4 πŸ” 5 πŸ’¬ 1 πŸ“Œ 0
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Interbreeding between Neanderthals and modern humans was strongly sex biased Sex biases in admixture and other demographic processes are recurrent features throughout human evolution. For admixture between Neanderthals and anatomically modern humans (AMHs), sex bias has been p...

When Neanderthals and ancient modern humans interbred, the pairings were mostly between male Neanderthals and female humans, according to a new Science study.

This finding helps explain why Neanderthal ancestry present in most humans is unevenly distributed. https://scim.ag/4cQYpIL

02.03.2026 22:44 πŸ‘ 36 πŸ” 13 πŸ’¬ 1 πŸ“Œ 2
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Brains of β€˜super agers’ are still strong producers of new neurons Nature - Older people with exceptional memory have a surprisingly high number of young neurons, study finds.

Older people with exceptional memory have a surprisingly high number of young neurons

go.nature.com/4cm8VYB

01.03.2026 10:41 πŸ‘ 67 πŸ” 13 πŸ’¬ 0 πŸ“Œ 1
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β€œThe military strikes by the U.S. and Israel against Iran violate international law and threaten regional and global security.”

Chair of The Elders, Juan Manuel Santos, calls for an immediate halt to military escalation.

28.02.2026 17:15 πŸ‘ 33 πŸ” 22 πŸ’¬ 0 πŸ“Œ 3
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COVID’s origins: what we do and don’t know Researchers summarize key insights from the world’s first comprehensive investigation into how a pandemic started.

After nearly 3.5 years of deliberations, researchers concluded their independent assessment of the origin of the coronavirus SARS-CoV-2

go.nature.com/4rEfsCJ

28.02.2026 08:59 πŸ‘ 50 πŸ” 23 πŸ’¬ 2 πŸ“Œ 4
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Are obesity drugs causing a severe complication? What the science says Nature - The United Kingdom and Brazil have issued warnings about a possible link between GLP-1 weight-loss drugs and pancreatic inflammation, but the connection is murky.

A rare and potentially fatal illness that might be linked to GLP-1 drugs is now causing alarm

go.nature.com/46to3j2

28.02.2026 14:47 πŸ‘ 40 πŸ” 11 πŸ’¬ 1 πŸ“Œ 1

The capsule of hypervirulent Klebsiella pneumoniae maintains neutrophils in neutral activation state https://www.biorxiv.org/content/10.64898/2026.02.24.707717v1

26.02.2026 05:17 πŸ‘ 0 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
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Homeostatic maturation programs drive human cDC2s into a tolerogenic state @cp-immunity.bsky.social
www.cell.com/immunity/ful...

20.02.2026 03:06 πŸ‘ 5 πŸ” 4 πŸ’¬ 0 πŸ“Œ 0
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Microglia makeover: On-demand control panel revamp Microglia display remarkable plasticity, with their cellular states evolving in response to developmental stage, regional context, and environmental or pathological stimuli. In this issue of Immunity, Hamagami et al. demonstrate that adaptive reconfiguration of regulatory networks, particularly the dynamics of enhancers, underlies these state transitions. Conserved enhancers link developmental and Alzheimer’s-related microglial states, suggesting shared epigenetic frameworks that influence neurodegenerative susceptibility.
15.02.2026 20:55 πŸ‘ 3 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0
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Local antibody feedback enforces a checkpoint on affinity maturation in the germinal center and promotes epitope spreading Feedback from circulating antibodies can shape initiating immune responses. Yan et al. examine ongoing germinal center (GC) responses upon immunization with an mRNA-LNP-encoded membrane-bound immunogen displaying three conserved HIV-1 envelope epitopes and find antibody-mediated intra-epitope competitive effects and a contribution of local antibodies to determining B cell residency in GCs and affinity maturation.

Online now: Local antibody feedback enforces a checkpoint on affinity maturation in the germinal center and promotes epitope spreading

15.02.2026 23:39 πŸ‘ 5 πŸ” 3 πŸ’¬ 0 πŸ“Œ 0
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A new systematic analysis of intermittent fasting from 22 randomized trials shows no advantage for weight loss or other outcomes compared with regular diet advice
www.cochranelibrary.com/cdsr/doi/10....

16.02.2026 01:02 πŸ‘ 277 πŸ” 80 πŸ’¬ 9 πŸ“Œ 10
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What's happening during attention lapses after poor sleep?
A fluid wave. Your brain is trying to clean itself, to wash away waste products.
nature.com/articles/s41...
gift link
wsj.com/health/welln...

14.02.2026 17:12 πŸ‘ 246 πŸ” 70 πŸ’¬ 4 πŸ“Œ 6
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World's oldest chocolate was made 5300 years agoβ€”in a South American rainforest Ancient pots shift the nexus of chocolatemaking from Central America to modern Ecuador

On #ValentinesDay, learn more about why our love affair with chocolate is much older than we thought. https://scim.ag/42WrGfI

14.02.2026 20:09 πŸ‘ 64 πŸ” 16 πŸ’¬ 0 πŸ“Œ 1

Next pandemic is gonna be lit πŸ”₯
We’ll all be chugging protein drinks and swallowing deworming tablets and talking about β€œthat which cannot be named” while our social media feeds tell us that anyone who died did not do enough push-ups…

13.02.2026 20:05 πŸ‘ 206 πŸ” 47 πŸ’¬ 5 πŸ“Œ 7
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#NIH to deprioritize pandemic preparedness and biodefense research, @nature.com reports, saying director Jay Bhattacharya wants to focus on known diseases, not possible future threats.
What could possibly go wrong?
www.nature.com/articles/d41...

13.02.2026 19:54 πŸ‘ 97 πŸ” 46 πŸ’¬ 4 πŸ“Œ 8
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Hello world. One of my favorite fun facts to share about elephants…their trunks are covered in whiskers, with built-in intelligence! If that got your attention…check out our new paper in @science.org www.science.org/doi/10.1126/...

13.02.2026 13:20 πŸ‘ 53 πŸ” 19 πŸ’¬ 1 πŸ“Œ 1
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A small polymerase ribozyme that can synthesize itself and its complementary strand The emergence of a chemical system capable of self-replication and evolution is a critical event in the origin of life. RNA polymerase ribozymes can replicate RNA, but their large size and structural ...

How could a simple self-replicating system emerge at the origins of life? RNA polymerase ribozymes can replicate RNA, but existing ones are so large that their self-replication seems impossible. Could they be smaller?

Excited to share our latest work in @science.org on a new small polymerase.
1/n

13.02.2026 11:42 πŸ‘ 498 πŸ” 210 πŸ’¬ 10 πŸ“Œ 28
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Meningeal B cells: Emerging players at the brain border Meningeal B cells are increasingly recognized as active players at the brain border. Chen and Xu review recent advances in understanding their heterogeneity, developmental origins, spatial organization, and diverse functions in health and disease, and they outline key open questions that will guide future investigations into B cell immunology within the meninges.
13.02.2026 23:38 πŸ‘ 5 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0
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Study supports shorter treatment regimens for TB prevention

A phase 4 trial in Brazil finds 1-month and 3-month treatment regimens are safe and effective options for preventing active tuberculosis.

www.cidrap.umn.edu/t...

11.02.2026 22:15 πŸ‘ 18 πŸ” 9 πŸ’¬ 0 πŸ“Œ 1
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Mexico reports more human New World screwworm infections

Mexico has now reported 141 human cases of the parasitic infection, which is spread by flies.

www.cidrap.umn.edu/n...

11.02.2026 22:22 πŸ‘ 26 πŸ” 20 πŸ’¬ 3 πŸ“Œ 2
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Rare, dangerous side effects of some COVID-19 vaccines explained β€œGroundbreaking” study uncovers why adenovirus-based shots caused life-threatening blood clots and bleeding in some people

Five years after the rollout of Covid-19 vaccines started, it seems the mystery of why the Astra-Zeneca and J&J vaccines led to a rare but deadly side effect of unusual blood clots and bleeding has finally been solved. 

It's a fascinating case of molecular mimicry that may help make vaccine safer.πŸ§ͺ

11.02.2026 22:10 πŸ‘ 620 πŸ” 246 πŸ’¬ 10 πŸ“Œ 23
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Study finds no link between COVID-19 vaccines and autism

A new study finds no increase in autism rates in babies born to mothers who received COVID-19 vaccines just before or during pregnancy, compared with children of unvaccinated moms.

www.cidrap.umn.edu/c...

11.02.2026 23:25 πŸ‘ 53 πŸ” 27 πŸ’¬ 0 πŸ“Œ 3
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New analysis links flu vaccination to 18% lower odds of heart attack

The findings of the meta-analysis draw on data from more than 23 million people.

www.cidrap.umn.edu/i...

09.02.2026 22:18 πŸ‘ 40 πŸ” 25 πŸ’¬ 1 πŸ“Œ 3
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Obesity is a major risk factor for severe infections across many types of pathogens for requiring hospitalization and/or fatal outcomes.
Data from 540,000 people.
@thelancet.com

thelancet.com/journals/lan...
(left-hospitalizations top, death bottom; right-pathogens)

10.02.2026 00:00 πŸ‘ 93 πŸ” 23 πŸ’¬ 3 πŸ“Œ 1
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Australian whooping cough cases are at their highest level in 35 years – so why the surge? This debilitating disease is particularly dangerous for babies, but can affect people at any age. Vaccination remains a key line of defence.

Australia is battling its biggest rise in whooping cough cases in 35 years. Also known as pertussis or the β€œ100-day cough”, whooping cough is a potentially fatal respiratory illness which causes severe coughing episodes.

So why the surge? The Conversation UK explores: bit.ly/3Mbkl6L

10.02.2026 07:00 πŸ‘ 2 πŸ” 3 πŸ’¬ 0 πŸ“Œ 0
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How tumours trick the brain into shutting down cancer-fighting cells Nature - Lung cancer in mice hijacks neurons to send a signal that subdues the immune system, study finds.

Lung cancer in mice hijacks neurons to send a signal that subdues the immune system

go.nature.com/4r3BazE

07.02.2026 12:27 πŸ‘ 53 πŸ” 14 πŸ’¬ 0 πŸ“Œ 1