Karim Labib

We have postdoctoral positions available, if you might like to join us to study genome integrity in the beautiful east of Scotland. If you're interested, please contact me at kpmlabib@dundee.ac.uk

TTF2 promotes replisome eviction from stalled forks in mitosis When cells enter mitosis with under-replicated DNA, sister chromosome segregation is compromised, which can lead to massive genome instability. The replisome-associated E3 ubiquitin ligase TRAIP mitig...

Complementary work from the Walter & Pellman groups:
www.biorxiv.org/content/10.1...

TTF2 drives mitotic replisome disassembly and MiDAS by coupling the TRAIP ubiquitin ligase to Polε Mammalian cells frequently enter mitosis before DNA replication has finished, necessitating the rapid processing of replication forks to facilitate chromosome segregation. The TRAIP ubiquitin ligase i...

Here's out latest manuscript, showing how the replisome is marked for destruction during mitosis, to trigger the processing of sites of incomplete DNA replication.
www.biorxiv.org/content/10.1...