Álvaro López Codina

CDK/mTOR-dependent phosphorylation of UBE2H restrains its charging with ubiquitin and regulates CTLH-dependent degradation https://www.biorxiv.org/content/10.64898/2026.03.07.710281v1

Arrestin-3 scaffolds multiple MAP3Ks driving stress-induced JNK3 activation and cell death. https://www.biorxiv.org/content/10.64898/2026.03.09.710604v1

🔬 Solving mitophagy mysteries: Study identifies Mfi2 as second #Yeasr mitofissin, working with Atg44 to fragment mitochondria during autophagy; reveals how mitochondria are cut when traditional Dnm1 machinery is dispensable

🧪 #YeastResearch #SGD #CellBiology
www.yeastgenome.org/reference/S1...

Organization of core mitochondrial replication components into multiphasic condensates www.biorxiv.org/content/10.6...

On the effect of lateral stretch on the deformation energetics of biological membranes and the lipid dynamics within https://www.biorxiv.org/content/10.64898/2026.03.06.710217v1

Cooperative Native Contact Formation Facilitates Free Energy Barrier Crossing in Protein Folding High-temporal-resolution fluorescence measurements reveal how quickly proteins cross energy barriers separating unfolded and folded states.

Original publication here: journals.aps.org/prl/abstract...

Nice overview of another cool #smFRET study, this time unpicking protein folding dynamics @timcraggs.bsky.social @ei-science.bsky.social

Why ‘quantum proteins’ could be the next big thing in biology Fluorescent proteins with a quantum upgrade could offer unprecedented views inside cells.

“In the past, it might have seemed like, ‘ah, that’s likely never going to work’,” says physicist Ania Jayich. “That’s not true any more.”

go.nature.com/3NdJMF1

Lysosomal Expansion Compartments Mediate Zinc and Copper Homeostasis in Caenorhabditis elegans https://www.biorxiv.org/content/10.64898/2026.03.05.709934v1

Apical spectrin organizes cortical actin filament bundles to pattern C. elegans cuticle ridges https://www.biorxiv.org/content/10.64898/2026.03.05.709908v1

Community perspective:

Toward a unified framework for determining conformational ensembles of disordered proteins 🍝

with framework for experimental data acquisition, computational ensemble generation & validation

Led by @hamidrgh.bsky.social, Silvio Tosatto & Alex Monzon

doi.org/10.1038/s415...

Clec16a maintains definitive hematopoietic stem and progenitor cells via mitophagy Cai et al. identify the E3 ubiquitin ligase CLEC16A as a conserved regulator of embryonic hematopoiesis. CLEC16A maintains the endothelial-to-hematopoietic transition by stabilizing ATG5 and promoting mitophagy, thereby balancing mitochondrial ROS and maintaining hematopoietic fate determination.

Clec16a maintains definitive hematopoietic stem and progenitor cells via mitophagy

GPR54 promotes progression & #MetabolicReprogramming in #NSCLC by enhancing dopa decarboxylase expression via the Gαq/11/PI3K/AKT/mTOR signaling pathway, underscoring its potential as both a #Biomarker & #TherapeuticTarget.

#OpenAccess: doi.org/10.1038/s413...

Fluorescence anisotropy structured illumination microscopy for quantitative super-resolved mapping of cell microenvironment and cytoskeletal dynamics https://www.biorxiv.org/content/10.64898/2026.03.06.710005v1

Ribosome Molecular Aging Shapes Translation Dynamics
www.biorxiv.org/content/10.6...

Microtubule detyrosination alters nuclear mechanotransduction and leads to pro-hypertrophic signaling in hypertrophic cardiomyopathy

www.biorxiv.org/content/10.1...

Shrinking a bottleneck in cryo-EM sample preparation pubmed.ncbi.nlm.nih.gov/41795457/ #cryoEM

FLEXTAG: a small and self-renewable protein labeling system for anti-fading multi-color super-resolution imaging - Nature Communications FLEXTAG is a versatile, self-renewing protein labeling system that enables long-term, multi-color super-resolution fluorescence imaging of subcellular structures in live and fixed cells, with minimal ...

www.nature.com/articles/s41...

RhoGEF12 regulates endosomal SORL1-retromer and its inhibition is therapeutic in human neuronal models of Alzheimer's disease https://www.biorxiv.org/content/10.64898/2026.03.06.709427v1

How fast does a protein fold? Real-time technique captures the moment Proteins assume complex 3D shapes even faster than does DNA, which is a simpler molecule.

Scientists say they have made some of the first direct measurements of how long it takes an individual, ordinary protein to fold – and the results were surprising.

go.nature.com/3N4UrSD

How fast does a protein fold? Real-time technique captures the moment Proteins assume complex 3D shapes even faster than does DNA, which is a simpler molecule.

🧪 How fast does a protein fold? Real-time technique captures the moment www.nature.com/articles/d41...

Actin-membrane interface stress regulates Arp2/3-branched actin density during lamellipodial protrusion https://www.biorxiv.org/content/10.64898/2026.03.06.710140v1

We just published a short conceptual review together with @angela-taddei.bsky.social on the spatial controls of homology search in both bacteria and eukaryotes. We discuss an emerging framework for homology search in cells with two main phases. Check it out: authors.elsevier.com/c/1mjyh,LqAZ...

Disorder Drives One of Nature’s Most Complex Machines | Quanta Magazine Every second, hundreds to thousands of molecules move through thousands of nuclear pores in each of your cells. A new high-definition view reveals the machine in action.

Behold the inner channel of the nuclear pore complex in all its messy glory. New high-def microscopy is revealing its intricacies like never before. @yaseminsaplakoglu.bsky.social reports: www.quantamagazine.org/disorder-dri...

TOLLIP targets GSDME-NT-carrying endocytic vesicles for autophagy to regulate pyroptosis and chemotherapy efficacy - Nature Cell Biology Xu, Li, Deng and colleagues identify a ubiquitin-dependent degradation mechanism for cleaved GSDME mediated by TOLLIP through endocytosis and autophagy. They show this modulates pyroptosis, antitumour...

www.nature.com/articles/s41...

Distinct TRAPP complexes activate Ypt/Rab GTPases in secretion and autophagy The mechanism by which the conserved Ypt1/Rab1 GTPases mediate the beginning of two cellular processes, secretion and autophagy, is unknown. Gyurkovska et

Distinct TRAPP complexes activate Ypt/Rab GTPases in secretion and autophagy url: rupress.org/jcb/article-...

Endosomal maturation is controlled by the trimeric Bulli-Mon1-Ccz1 GEF7 complex and Rab5-GTPase activating protein GAPsec www.biorxiv.org/content/10.6...

Eight common errors I see in PhD applications and interviews, and how to avoid them Convince a supervisor that you’re a great fit for their laboratory by preparing questions, honing your personal statement and showcasing strong team-player instincts.

Convince a supervisor that you’re a great fit for their laboratory by preparing questions, honing your personal statement and showcasing strong team-player instincts.

go.nature.com/4s00iHR

The mechanism by which the conserved Ypt1/Rab1 #GTPases mediate the beginning of #secretion and #autophagy is unknown. Gyurkovska, Segev et al. use in vivo analysis to show that distinct TRAPP complexes activate the yeast Ypt1 in secretion and autophagy rupress.org/jcb/article/...

Local heterochromatin enrichment promotes telomere clustering and PML nuclear body assembly at telomeres Telomeres in ALT-positive cancers display reduced nucleosome density yet retain heterochromatin-associated factors. This study shows that telomeric heterochromatin drives telomere clustering and PML nuclear body assembly, while ATRX and DAXX suppress this process, establishing a role for telomeric chromatin in mediating ALT-associated subnuclear compartmentalization of telomeres.

Local heterochromatin enrichment promotes telomere clustering and PML nuclear body assembly at telomeres