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Ed Hollox

@edhollox

Professor of Genetics at U of Leicester. Genome structural variation. "Anyone with gumption and a sharp mind will take the measure of two things: what's said and what's done." Views my own.

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14.09.2023
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Latest posts by Ed Hollox @edhollox

Really interesting ideas here. Taking context dependence of evolution/mutation, which we all happily illustrate with our favourite example (lactase persistence and phenylketonuria are my human examples) and giving it a quantitative framework called "genomic perplexity".

11.03.2026 12:43 πŸ‘ 2 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0

The always excellent @lucielaplane.bsky.social will give an online talk at 17:00 (Paris time) next Tuesday: "How Much Should Philosophers of Biology Engage with Biology?"

Zoom link at philinbiomed.cnrs.fr/event/lucie-...

11.03.2026 09:48 πŸ‘ 2 πŸ” 1 πŸ’¬ 1 πŸ“Œ 0

No ivermectin??

10.03.2026 12:14 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

Is it those anglo saxon boxes of bones at Winchester Cathedral that they are studying?

07.03.2026 21:25 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

The Tidyverse Is Not Enough

07.03.2026 17:30 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

Je n'ecris pas vite en francais, desole!

06.03.2026 16:11 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

Or MRC Units of that time, too. I don't agree with the article about that model lauding individuals over collaboration. Time, willingness to take a risk, and flat hierarchies facilitates collaboration rather than hinders it.

06.03.2026 16:10 πŸ‘ 2 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0

With Palin, it seemed much less about him. It wasn't a celebrity vehicle.

05.03.2026 12:21 πŸ‘ 3 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

"Chained to the mirror and the razor blade" is about shaving and the morning routine...

05.03.2026 06:59 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

This is great, but just because you can predict where the enhancers are likely to be, you can't really predict their function.

04.03.2026 21:56 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

For me, not even subtly different, but often completely different! Very often, rows of lights can be controlled independently, but perpendicular to the direction of teaching. So can dim left lights but not front lights...

04.03.2026 09:59 πŸ‘ 3 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

BYD cars are a common sight on the roads here in the UK.

04.03.2026 08:26 πŸ‘ 5 πŸ” 2 πŸ’¬ 1 πŸ“Œ 0

Out here in the provinces, literally thousands of em in a field. Dead crows littered beneath them. Not turning now, it being Ramadan.

03.03.2026 18:41 πŸ‘ 8 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
PearTree β€” Phylogenetic Tree Viewer

So I pleased to announce the conceptual spawn of FigTree: PearTree (acronym still to be finalised). If you want to dive right in it is hosted as a web app here: artic-network.github.io/peartree (click the β€œExample...” button for immediate candy and then click every button you can find).

28.02.2026 19:01 πŸ‘ 163 πŸ” 100 πŸ’¬ 5 πŸ“Œ 4

I predate MMR too (or it was later arriving in Norfolk...) but had MMR 25 years ago when I was working in Notts as there was a mumps outbreak amongst the students. As far as I remember I just asked for it and got it.

01.03.2026 12:39 πŸ‘ 2 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
Preview
Annotating genomes at increased scale and resolution - Nature Reviews Genetics In this Review, Ji et al. overview how rapidly advancing experimental and computational methods are enabling improved and automated annotation of gene structure and function, providing researchers wit...

The growing number of sequenced #genomes provides a positive feedback loop, in which database searches become more effective and shared sequence patterns emerge more clearly www.nature.com/articles/s41... #biodiversity #genomics

01.03.2026 10:57 πŸ‘ 27 πŸ” 8 πŸ’¬ 0 πŸ“Œ 0

Amazing peppered moth story from Saccheri lab - same locus, but different structural variants, underly parallel evolution of industrial melanism in the UK and across continental Europe.

27.02.2026 13:41 πŸ‘ 36 πŸ” 18 πŸ’¬ 1 πŸ“Œ 0

Another one for Warwick? Here our colour is red, probably in homage to the cheese.

27.02.2026 15:18 πŸ‘ 2 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

Purple seems to be quite popular - see Manchester. I'm sure you have tone of voice guides too.

27.02.2026 14:24 πŸ‘ 1 πŸ” 0 πŸ’¬ 2 πŸ“Œ 0

Synergy, going forward... or something like that.

27.02.2026 14:14 πŸ‘ 2 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

"It looks like socialism, Justin!"
One for the merch.

27.02.2026 08:56 πŸ‘ 1 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
Preview
Concurrent L1 retrotransposition events promote reciprocal translocations in human tumorigenesis LINE-1 (L1) retrotransposition generates somatic genomic variation in human cancer, but short-read sequencing has limited our understanding of its structural consequences and dynamics. Using long-read...

Today in
@science.org:
We are pleased to present our last work entitled:
"Concurrent L1 retrotransposition events promote reciprocal translocations in human tumorigenesis"
by Zumalave et al.
www.science.org/doi/10.1126/...

26.02.2026 19:08 πŸ‘ 40 πŸ” 27 πŸ’¬ 3 πŸ“Œ 0
Post image

Hours of fun.

26.02.2026 21:43 πŸ‘ 0 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0

Preparing for UEA Kazakhstan...

26.02.2026 21:32 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

Can safely way this is the craziest and coolest study I have led. We chart the evolution of sheeppox virus, finding it in the Eurasian steppe ~3700 years ago, and also in a LOT of parchment from medieval Europe (made from a range of animals skins!) #aDNA

25.02.2026 07:45 πŸ‘ 56 πŸ” 23 πŸ’¬ 5 πŸ“Œ 1

Because the only reason to understand something is to be exploited for that understanding...

25.02.2026 15:59 πŸ‘ 2 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
Creating actually publication-ready figures for journals using `ggplot2` A practical guide to creating publication-ready figures in R using ggplot2, covering journal dimension requirements, custom themes, updated geom defaults, and SVG exportβ€”with minimal manual adjustment...

#rstats Here's a useful guide to creating publication-ready #ggplot figures to journal specifications, which is often quite fiddly.

jaquent.github.io/2026/02/crea...

24.02.2026 13:47 πŸ‘ 76 πŸ” 23 πŸ’¬ 3 πŸ“Œ 3
PopGeneJS PopGeneJS

PopGeneJS is a free web platform for teaching population genetics with 32 interactive modules on various topics. It offers real-time visualizations and requires no installation. Explore at https://popgenejs.bioinformat.org.

24.02.2026 17:09 πŸ‘ 13 πŸ” 4 πŸ’¬ 0 πŸ“Œ 0
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Faculty Under Attack: How the public syllabus policy is seen as the latest weapon against academia Faculty across the UNC System are expressing increased concerns that their safety is at risk following the new UNC System policy that all class syllabi be posted in an online database.

Lest ye think that only humanities profs need to worry about this, remember what Stalin did to the geneticists.

24.02.2026 19:04 πŸ‘ 1 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
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The true beginning of troubles? The Parliament of Bats, 1426 - The History of Parliament Dr Hannes Kleineke explores the acrimonious 'Parliament of Bats', which first met in Leicester on this day 600 years ago, amidst tensions between two of Henry

600 years since the parliament of bats was held in Leicester historyofparliament.com/2026/02/18/p...

23.02.2026 23:21 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0