VCP/p97’s accessory adapters (FAF1, FAF2, UBXN7) boost unfolding and subsequent proteasomal degradation. #ubiquitin. Our paper is out now:
Science Advances www.science.org/doi/10.1126/...
Why do pathological protein aggregates persist in cells and how can we overcome this?
In our new preprint, we show that Tau aggregates fail to initiate selective autophagy and that their autophagic degradation can be restored.
#Autophagy #Tau #Proteostasis
Out now 👇 www.biorxiv.org/content/10.6...
Very happy to share our new preprint on #Golgi #PQC Very grateful to be working at the @hellerschmiedlab.bsky.social and with all the co-authors and colleagues. Special thanks to Sofia- without her, this story wouldn't have #unfolded as it did @unidue-zmb.bsky.social @imprs-lm.bsky.social
happy to see this important work out - great paper from @joaodiamantino.bsky.social at @hellerschmiedlab.bsky.social lab identifying Golgi quality control and first EGAD components in human cells - excellent!
Welcome, mammalian EGAD pathway :-)
Postdoc job alert at Institut Jacques Monod in Paris! Interested in fundamental membrane trafficking? We seek a postdoc to study collagen secretion as a model for core principles of how cells and their environment build each other. emploi.cnrs.fr/Offres/CDD/U...
No bull: This Austrian cow has learned to use tools.
Learn more: https://scim.ag/3LYTXNd
Come join us for a newly funded @horizoneu.bsky.social @globalhealthedctp3.bsky.social project on CHIKV vaccine responses in vulnerable populations in Africa. We seek a highly motivated and skilled #postdoc and #projectmanager. Please find details here: virologie.i-med.ac.at/career/ #lovevirology
We are excited to share our new preprint which is now available to read on biorXiv: doi.org/10.64898/202... 🎉🎉🎉
Organelles harbour pH gradients https://www.biorxiv.org/content/10.64898/2025.12.12.694065v1
New preprint from the lab!!🎉
We show that Asgard archaea ESCRT-III proteins can trigger membrane fission and reveal its molecular mechanism, offering clues to how these cells may have built internal compartments. But do these organisms even have these compartments?
www.biorxiv.org/content/10.1...
New preprint out! We show that PROTAC-induced ubiquitination can bypass canonical ERAD to degrade ER membrane proteins. Wonderful collaboration w/ @dannomura.bsky.social and huge credit to grad student superstar Sydney Tomlinson!
www.biorxiv.org/content/10.1...
Yeast cells utilize a TORC2 feedback loop for plasma membrane adaptation to mechanical stress, with increased sterol transport from plasma membrane to endoplasmic reticulum activating TORC2 signaling
Robbie Loewith, Aurélien Roux @rouxlab.bsky.social and coworkers
www.embopress.org/doi/full/10....
bravo Maria 👍🥳
...explores an 'experiment of nature' to highlight the broad principles underlying the organisation and evolution of membrane homeostasis....
cool!
....explores an 'experiment of nature' to highlight the broad principles underlying the organisation and evolution of membrane homeostasis....
cool!
👏👏
We have wondered what a complex archaeal cell might look like ever since 2014. It’s been a long road (and the journey is far from over), but it’s a good time to pause for breath and look. These Asgard archaeal cells are a surprise! And that is the joy of being a cell biologist.
An Asgard archaeon with internal membrane compartments
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
📢 Open Call! The Max Perutz Labs invite applications for a Full Professorship in Integrative Structure Biology with a focus on in situ structural biology using cryo-electron tomography (cryo-ET) and related methods. More details ➡️ tinyurl.com/brswbymu
Our latest review is now online! 👇
@martenslab.bsky.social
Mechanism of autophagy initiation by transmembrane selective autophagy receptors | The EMBO Journal www.embopress.org/doi/full/10....
👏👏
Proud to share a preprint of our paper on how bridge-like lipid transport protein VPS13C senses lysosomal membrane tension in anticipation of membrane lesions to initiate net ER-to-lysosome lipid transfer for efficient lysosomal repair www.biorxiv.org/content/10.1...
How do cells curb nutrient uptake during quiescence & does it matter?
@teislab.bsky.social & Co. show TXNIP-dependent endocytosis of amino acid transporter LAT1/SLC7A5 is essential to prevent cell death and human disease
#RefereedPreprint c/o @reviewcommons.org
www.embopress.org/doi/full/10....
Quiescent cells stay alive by eating less. They downregulate amino acid transporters to match reduced demand. When this brake fails -> cell death & disease.
More info in our new paper 👇
Just out in @science.org: Together with the lab of @wilhelmpalm.bsky.social, we used sequential in-vitro/in-vivo CRISPR screens to decipher metabolic adaptations in tumors. We find that acidosis is a dominant factor that shapes energy metabolism and stress resilience. www.science.org/doi/10.1126/...
Allosteric activation of a ubiquitin ligase by an internal kinase domain! Congratulations to our team member Thornton Fokkens for this fascinating discovery in a neglected disease area with strong therapeutic need. Many thanks to all our great collaborators!
www.sciencedirect.com/science/arti...
🥳 MEGA NEWS: Michi Ebner has been awarded an ERC Starting Grant for his research on Lysosomal Lipid Logistics!
PhD students and Postdocs: Join him at the Institute of Molecular Biochemistry (biochem.i-med.ac.at/ebner) at the Biocenter of the Medical University of Innsbruck!
Just awesome science!
come for a visit
rob! way to go🥳 congrats!
