Garrett Fogo

Our study “Genetic and proteomic analysis identifies BAG3 as an amyloid‑responsive regulator of neuronal proteostasis" was published in Acta Neuropathologica this week! Congratulations to lead author Zach Augur, who will be defending his thesis later this week!!
link.springer.com/epdf/10.1007...

Optineurin deficiency disrupts phosphorylated tau proteostasis and clusterin expression in human neurons - Acta Neuropathologica Communications Optineurin (OPTN) is an autophagy adaptor protein involved in selective autophagy, including aggrephagy and mitophagy. Pathogenic mutations in OPTN have also been linked to amyotrophic lateral scleros...

New TYP lab publication from co-authors
Zach Augur and @garrettfogo.bsky.social
on deciphering the function of Optineurin in iPSC-derived Neurons and Astrocytes! This will be the first of 3 first-author publications from Zach's PhD thesis! link.springer.com/article/10.1...

Optineurin deficiency disrupts phosphorylated tau proteostasis and clusterin expression in human neurons - Acta Neuropathologica Communications Optineurin (OPTN) is an autophagy adaptor protein involved in selective autophagy, including aggrephagy and mitophagy. Pathogenic mutations in OPTN have also been linked to amyotrophic lateral scleros...

actaneurocomms.biomedcentral.com/articles/10....

The role of cardiolipin in mitochondrial dynamics and quality control in neuronal ischemia/reperfusion injury - Cell Death & Disease Cell Death & Disease - The role of cardiolipin in mitochondrial dynamics and quality control in neuronal ischemia/reperfusion injury

Thankful to have contributed to this great review by Katlynn Emaus from @sandersonlab.bsky.social on cardiolipin in mitochondrial dynamics and mitohagy

www.nature.com/articles/s41...

CLU alleviates Alzheimer’s disease-relevant processes by modulating astrocyte reactivity and microglia-dependent synaptic density Genetic studies implicate clusterin (CLU) in the pathogenesis of Alzheimer’s disease (AD), yet its precise molecular impact remains unclear. Through u…

Thrilled to share my first first-author paper is out
@cp-neuron.bsky.social! We show that Alzheimer's disease protective CLU alleles upregulate CLU in response to neuropathology, dampening inflammatory signaling between microglia and astrocytes.

Read here www.sciencedirect.com/science/arti...

Agent-based modeling of neuronal mitochondrial dynamics using intrinsic variables of individual mitochondria Mitochondrial networks undergo remodeling to regulate form and function. The dynamic nature of mitochondria is maintained by the dueling processes of mitochondrial fission and fusion. Dysfunctional mi...

The final bit of my PhD work from the Sanderson Lab is now out in iScience!

Agent-based modeling of neuronal mitochondrial dynamics using intrinsic variables of individual mitochondria: iScience www.cell.com/iscience/ful...

Mitochondrial dynamics and quality control regulate proteostasis in neuronal ischemia-reperfusion Mitochondrial damage and dysfunction are hallmarks of neuronal injury during cerebral ischemia-reperfusion (I/R). Critical mitochondrial functions including energy production and cell signaling are...

Happy to share a large part of my PhD work that is now published in Autophagy!

www.tandfonline.com/doi/full/10....