Carrisa V. Cocuzza, PhD (she/her)

Working with this group of talented, kind, and inspiring folks has been truly amazing! Highly recommend applying and/or sharing this posting! 🧠🥼🤘🏽

Great write up of the @nature.com study on MRI economics by @bttyeo.bsky.social's research group!

With @avramholmes.bsky.social @sidchop.bsky.social @carrisacocuzza.bsky.social

Thanks!! 🙌🏽 No but HCP derivatives are on NDA and a more select set of cleaned data on OpenNeuro (what I used for FC) - I’ll talk to our group about sharing FC!

Check out my newest preprint to see the TCP dataset in action! 🤘🧠

Brain network dynamics reflect psychiatric illness status and transdiagnostic symptom profiles across health and disease: www.biorxiv.org/content/10.1...

We rec. you cite the Sci. Data manuscript when using the TCP:

Chopra, S., Cocuzza, C.V., Lawhead, C. et al. The Transdiagnostic Connectome Project: an open dataset for studying brain-behavior relationships in psychiatry. Sci Data 12, 923 (2025). doi.org/10.1038/s415...

Happy sciencing all!! 🎉🧠⚛️

The TCP dataset is openly available on:

OpenNeuro: openneuro.org/datasets/ds0...
NDA: nda.nih.gov/study.html?i...

🧵9🧠

...And validated the use of the TCP for discoverability of large-scale functional network properties and task activation effects 🧵8🧠

We did extensive QC analyses showing that motion was well-controlled by HCP processing... 🧵7🧠

MRI data includes high-resolution anatomicals, 4 rest fMRI, & 2 task fMRI (Stroop & Emotional Faces). We used HCP processing pipelines w/ ICA-FIX denoising & encourage the use of TCP for clinical network neuro research questions! 🧵6🧠

The TCP dataset has 50+ self-report & clinician-assisted behavioral, cognitive, and & clinical measures. We are enthusiastic about the use of TCP toward empirically-driven, dimensional, & hierarchically-informed phenotyping 🧵5🧠

The TCP dataset includes MRI, fMRI, & richly-sampled behavioral data from participants with and without psychiatric diagnoses, sampled transdiagnostically 🧵4🧠

And those of the team not (yet) on bsky! 🎉 Connor Lawhead, Poornima Kumar, Arielle Rubenstein, Julia Moses, Lia Chen, Crystal Blankenbaker, Bryce Gillis, & Justin Baker 🧵3🧠

HUGE congrats and thank you to the team & collaborators!! 🎉@sidchop.bsky.social @jocelynricard.bsky.social @loiclabache.bsky.social labache.bsky.social @neurlo.bsky.social @lauragermine.bsky.social @harpaz-rotem.bsky.social @bttyeo.bsky.social @avramholmes.bsky.social @holmeslab-bhi.bsky.social 🧵2🧠

The Transdiagnostic Connectome Project: an open dataset for studying brain-behavior relationships in psychiatry - Scientific Data Scientific Data - The Transdiagnostic Connectome Project: an open dataset for studying brain-behavior relationships in psychiatry

🚨 Dataset & Manuscript alert! 🚨 The Transdiagnostic Connectome Project (TCP) manuscript is now available @natureportfolio.nature.com Scientific Data! 🎉

www.nature.com/articles/s41...

🧵1👇

a man with a mustache is holding a piece of paper with the word science written on it . ALT: a man with a mustache is holding a piece of paper with the word science written on it .

I’m so pleased to share and discuss this work with our community! A massive thank you to coauthors who supported and guided me in this project!! @avramholmes.bsky.social @sidchop.bsky.social @ashleasegal.bsky.social @loiclabache.bsky.social @rowenaechin.bsky.social & Kaley Joss 🧵9/9🧠

🚨Conclusions🚨 Brain network dynamics link w/ dimensions of functioning across health & psychiatric disease & flatten w/ cognitive demand in patients, suggesting failure to recruit processing resources. Prominence of cognitive control suggests executive dysfunction cuts across psychopathology 8/9

Further emphasizing the importance of cognitive control processing to transdiagnostic symptomatology: rest-to-Stroop-task shifts in connectivity discriminated symptom fingerprints better than all other models 🧵7/9🧠

3. Network dynamics discriminated symptom fingerprints w/ high accuracy; more robustly than the presence of disease or primary diagnosis. Simulating lesions to each functional system: this link was established by info. processing along frontoparietal, somato/motor, visual, & thalamic networks 🧵6/9🧠

2. Whole-brain functional connectomes from resting- & task-state fMRI were decomposed to reveal dynamic constraints on across-state shifts in connectivity. Relative to healthy participants, patients had *flattened* dynamics, suggesting “de-differentiated” network structure in psychopathology 🧵5/9🧠

1. We used hierarchical methods on 110 behavioral, cognitive, & clinical measures & profiled 4 core dimensions of functioning: internalizing, externalizing, cognitive, & social/reward. We then developed *symptom fingerprints* – individualized expression patterns across these 4 dimensions 🧵4/9🧠

Using the 11 diagnoses in the Transdiagnostic Connectome Project we tackled 3 Qs: 1. What dimensions of functioning pattern psychiatric symptoms? 2. How are dynamics impaired in patients? 3. Do dynamics classify symptom dimensions > diagnoses? 3/9

in-press Sci. Data: www.medrxiv.org/content/10.1...

Brain network dynamics – the nonstationary flow of information across brain systems – map individual diffs. in cognition/behavior better than activity or temporally-fixed connectivity alone. This has been shown in depression and schizophrenia; we asked if this extends transdiagnostically… 🧵2/9🧠

🚨Preprint!🚨 So excited to share my 1st major study as a postdoc at @holmeslab-bhi.bsky.social!🤘

www.biorxiv.org/content/10.1...

Using a transdiagnostic framework, we found that brain network dynamics were able to discriminate individualized psychiatric symptom profiles with high accuracy 🧵1/9👇

The molecular and cellular underpinnings of human brain lateralization Hemispheric specialization is a fundamental characteristic of human brain organization, where most individuals exhibit left-hemisphere dominance for language and right-hemisphere dominance for visuosp...

🚨 New #preprint: The molecular and cellular underpinnings of human brain lateralization

🔗 doi.org/10.1101/2025...

🧠 We identify an acetylcholine-norepinephrine axis underlying functional lateralization, along with mitochondrial and cellular correlates. 🧵1/9👇

#neuroskyence

a man applauds with the words so proud of my team above him ALT: a man applauds with the words so proud of my team above him

Excited to share the first major piece of work and preprint from my lab! Led by Jason Kim! 🥳🎉🤘

www.biorxiv.org/content/10.1...

Concerned about the neurobiological impacts of long COVID? Interested in brain dynamics? Please do join us for @carrisacocuzza.bsky.social's talk on the 31st (see below).

It’s 11:30 pm and I just completed and submitted a grant due at midnight - this is the closest I get to an adrenaline rush as an academic 😅 … 🤘🏽

Welcome to the Bluesky account for Stand Up for Science 2025!

Keep an eye on this space for updates, event information, and ways to get involved. We can't wait to see everyone #standupforscience2025 on March 7th, both in DC and locations nationwide!

#scienceforall #sciencenotsilence

I'm thrilled to share that my graduate school project was just published in Nature Mental Health! We found that resting-state functional network predictors are more similar within vs between categories of internalizing and externalizing behavior in children (ABCD), adolescents (HBN) and adults (HCP)