I was looking up the history of SGLT2 inhibitors and found this article on “phlorizinized men” and saw the first paragraph included “this evidence is direct and unequivocal in the case of the aglomerular fish” which made me double check the authors and sure enough there was
Homer W. Smith
New nationwide data from nearly 1M adults with kidney disease show that COVID-19 vaccination and boosters were associated with lower infection rates and reduced 30-day mortality across all levels of kidney function—including advanced CKD and dialysis. #JGIM #COVID19 rdcu.be/eRXes
And it’s live
Iptacopan in C3GN makes it to @thelancet.com
www.thelancet.com/journals/lan...
#NephSky
As such, a population likely already initiated on RASi and SGLT2i if indicated
Plausibly a methodological issue, patients were identified based on CKD diagnosis codes in the National Patient Register. In Denmark, CKD codes are predominantly recorded in patients followed in outpatient clinics at nephrology departments i.e. patients already receiving specialized nephrology care
Appraise for the interim analysis of the #VISIONARY trial in IgAN at #ERA25
Great #ACHIEVE ment by @lastwalsh.bsky.social and colleagues presented at the #ERA25. An important study that will hopefully be published accordingly.
A graph of the least-squares mean ratio of the change from baseline in the urinary albumin-to-creatinine ratio in the full analysis population.
In the CONFIDENCE trial in persons with chronic kidney disease and type 2 diabetes, combination therapy with finerenone and empagliflozin led to a greater reduction in the urinary albumin-to-creatinine ratio than either drug alone. Full trial results: nej.md/4jEVbbk
#ERA25 #MedSky #Nephrology
just learned this & mind blown 🤯
CKD-EPI, MDRD etc give us GFR corrected for body surface area (ml/min/1.73m2)
BUT we're supposed to use the *absolute* GFR (ml/min) for drug dosing (eg KDIGO 2024 guidelines below; FDA agrees)
in obesity, the computer's ml/min/1.73m2 can be way too low #EMIMCC
How do these figures translate to the absolute scale? VW sales seem to have remained relatively stable over time www.statista.com/statistics/2...
Immunosuppressive Regimen and Post-Transplantation Clinical Course.
Also published today
The Boston first in human kidney xenotransplantation case report
@nejm.org #ISNWCN
www.nejm.org/doi/full/10....
New From PD Dr Sparks and Colleagues Dr Java in JASN
Post-transplant Thrombotic Microangiopathy
pubmed.ncbi.nlm.nih....
Corresponds to doubling of creatinine, the original surrogate kidney endpoint
🆕 Antibody identified in podocytopathies 🫘after Anti nephrin Ab⭐
Anti Slit diaphragm Ab ‼️‼️‼️
The heterogeneity in response to immunosuppression is understandable now!
#Nephsky
20 years after their initial MPA model, Xiao, Falk & Jennette publish a groundbreaking paper (doi.org/10.1016/j.ki...). They introduce 3 new mouse models for #ANCA #vasculitis, using anti-MPO abs with different stimuli to mimic MPA, GPA, and EGPA phenotypes. 🧵1/5
Happy to connect, interests include clinical and research aspects of AAV, IgA and complement-driven diseases, thx.
🧵 My first ever #Skytorial #MedSky #NephSky
🤩Cool study from #AHA24, published in @jamacurrent.bsky.social
📌The premise: HFpEF is characterized by increased left ventricular (LV) chamber pressures
🚀🧑🚀But what happens if 0 gravity (0G)?
jamanetwork.com/journals/jam...
Glucagon-like Peptide-1 Receptor Agonists: New Evidence of Kidney and Cardiovascular Protection From the FLOW and SELECT Trials 👇👇👨🔬🧪🥼 #cardiacsky #nephsky #medsky #cardiovascular #kidneydisease #Type2diabetes #semaglutide
www.ajkd.org/article/S027...
Further sprinting towards intensive blood pressure lowering in TD2 👍🏻
Guess what the kidney outcomes look like…
#BROAD RCT presented at #AHA24 and in NEJM 👇
www.nejm.org/doi/full/10....
1/14
🤔 Why do we use iodine as an intravenous contrast agent?
The answer requires a review of the composition of the human body and a brief tour of one of my favorites, the Periodic Table of Elements.
📣Tirzepatide for Heart Failure with Preserved Ejection Fraction and Obesity 👇👇 #cardiovascular #cardiosky #Obesity #diabetes #GLP-1 #heartfailure
www.nejm.org/doi/full/10....
Hypochloremia is associated with diuretic resistance. In 👇 study from Yale, hypochloremia was associated with poor diuretic efficiency (defined as mmol of UNa per doubling of loop diuretic dose). Of note - serum sodium was NOT associated with diuretic efficiency #cardiosky
First post on 🦋 #nephsky
Papers from the WEROCK Study on CRRT for AKI in children, young adults #CRRTnotCKRT
1️⃣ Demographics, outcomes- in AJKD; free till 11/30/24 www.ajkd.org/article/S027...
N=980; Significant practice changes in the 20 yrs since ppCRRT; Survival to ICU discharge ⬆️ (64%)
Wanted to share some thoughts on our recent publication in JAMA Pediatrics "Glomerular Filtration Rate Changes Following UTI in Children With Vesicoureteral Reflux" which we presented at Kidney Week and published simultaneously. jamanetwork.com/journals/jam...
Am not certain, but don’t think I’ve made the list, would appreciate the add. Thx
Need to get #nephrology #FOAMed going here
www.renalfellow.org/foamed/
#SkyNeph #NephSky
