Burge Lab

A new way to understand and predict gene splicing The KATMAP model, developed by researchers in the Department of Biology, can predict alternative cell splicing, which allows cells to create endless diversity from the same sets of genetic blueprints.

Check out this article about the latest publication from our lab, highlighting our new method, KATMAP, for understanding and predicting gene splicing
news.mit.edu/2025/katmap-...

four scientists outside state house of MA, smiling, posing for a selfie during a protest

Chris and our lab members (pictured here), along with many other labs from MIT Biology Dept, came out to protest today during "Stand Up for Science" day!! Keep it up @standupforscience.bsky.social

Sequence-dependent and -independent effects of intron-mediated enhancement learned from thousands of random introns Abstract. Spliceosomal introns are a ubiquitous feature of eukaryotic genes, whose presence often boosts the expression of their host gene, a phenomenon kn

Congrats to Burge lab alumna Dr. Kowal: her work on intron mediated enhancement (IME) of gene expression is officially published in Nucleic Acids Research!

academic.oup.com/nar/article/...

LUC7 proteins define two major classes of 5′ splice sites in animals and plants - Nature Communications Non-coding introns are excised from RNA transcripts of most eukaryotic genes by splicing. Here, Kenny et al. show that LUC7 proteins promote the splicing of different subsets of introns with distinct ...

Here is the research article, published today in Nature Communications:

www.nature.com/articles/s41...

MIT biologists discover a new type of control over RNA splicing MIT biologists discovered a new type of RNA-splicing regulation that helps to determine which protein-coding exons will be included in messenger RNA transcripts.

Congrats to Burge Lab PhD Student Connor Kenny on receiving an MIT news feature, highlighting his graduate work, uncovering how the LUC7 class of proteins control subclasses of RNA splicing events:

news.mit.edu/2025/mit-bio...

@mitnews