Sara França

What method should you use to track migrating cells?

Read "Methods to analyze cell migration data: fundamentals and practical guidelines" to find the best cell tracking tool.

Download the paper here: www.nature.com/articles/s41...

Cancer Dormancy Institute Service Core | Montefiore Einstein Comprehensive Cancer Center | Patient Care | Montefiore Einstein Support your cancer dormancy research with expert models, markers, and protocols from Montefiore Einstein’s Cancer Dormancy Institute Service Core.

The CDI announces the launch of the Cancer Dormancy Institute Service Core. The Core provides expert advice on markers, mouse, avian and 3D models, protocol development and rare cell isolation methods to explore dormancy, MRD & relapse biology across cancers.
montefioreeinstein.org/cancer/resea...

7/7
Register here — it's free:
www.bihealth.org/en/translati...
Tag someone who should know about this!

And if you're already working in this space, please send me a DM, I’d love to connect 🤝🏼
Let’s make evidence stronger together.
#SysRev #MetaScience #AI #systematicreviews #research #science

6/7
Want to be part of a generation that values both discovery and reflection?
This is a good place to start.
Let’s bring preclinical research into ✨the era of synthesis✨
#OpenScience #TranslationalResearch

5/7
Whether you're working on #cancer, #neuroscience, #immunology, or beyond, this approach is a powerful way to:

👉🏼 Reduce waste
👉🏼 Improve rigor
👉🏼 Strengthen the science we build on

And yes, it definitely applies to your 🐁 studies.
#RigorousScience #AnimalStudies

4/7
And guess what?
You don’t need to be a meta-analyst to start learning.
There’s an amazing free workshop coming up hosted by the Berlin Institute of Health & CAMARADES Berlin:
🗓️ May 26–28
⏰ 1–5pm CET (online)
I’ll be attending, and you can too!
#TrainingOpportunity #academia

3/7
Systematic reviews in preclinical research can:
✅ Reveal trends & contradictions
✅ Identify publication bias
✅ Quantify effect sizes
✅ Evaluate study quality
✅ Guide future experiments
They help us see the forest and the trees.
#EvidenceSynthesis #SysRev

Lost in translation: the valley of death across preclinical and clinical divide – identification of problems and overcoming obstacles - Translational Medicine Communications A rift that has opened up between basic research (bench) and clinical research and patients (bed) who need their new treatments, diagnostics and prevention, and this rift is widening and getting deepe...

2/7
We often hear that translation fails from bench to bedside.
But the problem isn’t always the biology, it’s the evidence base.
Bias, poor reporting, underpowered studies...
#SystematicReviews help us clean up that foundation before we build on it.

doi.org/10.1186/s412...

✨Most of us learn how to design experiments.
But how often are we taught to synthesize what already exists?
I’ve recently been exploring #SystematicReview of preclinical studies, and I truly believe more researchers should too.
Here’s why…
🧵1/7
#SysRev #academia #AI #phdlife

💡 Repost & share with your peers who might find these papers useful! Also, drop any relevant paper I might have missed in the comments.

See you next week! 📝

#Cancer #NIH #Metastasis #immuno #BreastCancer #science #LCSM #melanoma #ProstateCancer #PancreaticCancer

Immunosuppressive myeloid cells induce mesenchymal-like breast cancer stem cells by a mechanism involving membrane-bound TGF-β1. Suppressive myeloid cells play a central role in cancer escape from anti-tumor immunity. Beyond their immunosuppressive function, these cells are capable of exerting multiple other pro-tumoral activit...

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Resistance to Radiation Enhances Metastasis by Altering RNA Metabolism The cellular programs that mediate therapy resistance are often important drivers of metastasis, a phenomenon that needs to be understood better to improve screening and treatment options for cancer p...

39. www.biorxiv.org/content/10.1...
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Microbiome dysbiosis, neutrophil recruitment and mesenchymal transition of mesothelial cells promotes peritoneal metastasis of colorectal cancer - Nature Cancer Li et al. show through single-cell and functional data that tumor microenvironment remodeling promotes peritoneal metastasis of colorectal cancer through microbiome dysbiosis, neutrophil recruitment a...

31. www.nature.com/articles/s43...
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38. www.biorxiv.org/content/10.1...

Invasion and metastasis in cancer: molecular insights and therapeutic targets - Signal Transduction and Targeted Therapy Signal Transduction and Targeted Therapy - Invasion and metastasis in cancer: molecular insights and therapeutic targets

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DCLK1-mediated regulation of invadopodia dynamics and matrix metalloproteinase trafficking drives invasive progression in head and neck squamous cell carcinoma - Molecular Cancer Background HNSCC presents a significant health challenge due to its high mortality resulting from treatment resistance and locoregional invasion into critical structures in the head and neck region. U...

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9. aacrjournals.org/cancerres/ar...
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1. aacrjournals.org/mcr/article-...
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📢 Collection of Articles on #Metastasis & #TME (02.18.2025 – 02.27.2025)

🔍Check the image for titles & numbers, and find the links below:

Feel free to drop relevant papers I might have missed in the comments!

#Cancer #oncology #Immunology #ScienceDay #Health #NIH #Science #SaraMetastasisUpdates

Brd7 loss reawakens dormant metastasis initiating cells in lung by forging an immunosuppressive niche - Nature Communications Metastasis-initiating cells can reawaken from a dormant state that initially allowed them to survive, triggering metastatic outgrowth. Here, authors show that loss of Brd7 promotes an immunosuppressiv...

8/ This study adds another piece to the metastatic #dormancy puzzle. Understanding how dormant cells wake up gives us new tools to fight #cancer. Read the full paper here:
www.nature.com/articles/s41...

What do you think of these findings? Let’s discuss! 🔬
#metastasis #Oncology #Immunology

7/ These findings highlight new strategies to combat metastatic recurrence, targeting both epigenetic regulation and immune interactions. Restoring Brd7 expression or modulating the immune response could be the future of metastasis treatment.

6/ The good news? This process can be reversed! Inhibiting NET formation with sivelestat or depleting neutrophils significantly reduced metastatic growth. Blocking CTLA-4 (an immune checkpoint) also restored anti-tumor immunity.

5/ Neutrophils aren’t just bystanders. In this scenario, they create an immunosuppressive niche by releasing neutrophil extracellular traps (NETs), which help metastatic cells survive and contribute to T cell exhaustion.

4/ Without Brd7, cancer cells downregulate MHC-I, making them less visible to the immune system. At the same time, they secrete pro-metastatic cytokines, attracting inflammatory neutrophils and exhausted CD8+ T cells.

3/ In breast cancer metastasis models, Brd7 loss reactivates dormant metastatic cells in the lung, leading to aggressive tumor growth. But it’s not just about the tumor cells—the immune microenvironment also shifts dramatically.

2/ The study focuses on Brd7, a subunit of the PBAF chromatin remodeling complex. This complex regulates DNA accessibility, influencing how cancer cells behave in new tissues. But what happens when Brd7 is lost?

1/ Metastasis can stay dormant for years before reactivating and becoming lethal. But what wakes them up? A new study uncovers a fascinating mechanism involving epigenetics and immune suppression. Let’s break it down! 🧵

#metastasis #cancer #oncology #science #Immunology #dormancy

We're pleased to announce the next webinar from our Early Career Leadership Council.

Join us on March 4th to hear from Dr Ashley Laughney on "Tackling the genotype-to-phenotype problem in cancer evolution"

Sign up here → us02web.zoom.us/webinar/regi... ←

💡 Repost & share with your peers who might find these papers useful! Also, drop any relevant paper I might have missed in the comments. See you next week! 📝

#Cancer #Research #Metastasis #TumorMicroenvironment #Oncology #medsky #immunology

Extracellular vesicles from the lung pro-thrombotic niche drive cancer-associated thrombosis and metastasis via integrin beta 2 Cancer-associated thrombosis is a leading cause of mortality. Lucotti et al. uncover the formation of a pro-thrombotic niche in the non-metastatic lung microenvironment that promotes thrombosis and me...

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The liver-specific long noncoding RNA FAM99B inhibits ribosome biogenesis and cancer progression through cleavage of dead-box Helicase 21 - Cell Death & Disease Cell Death & Disease - The liver-specific long noncoding RNA FAM99B inhibits ribosome biogenesis and cancer progression through cleavage of dead-box Helicase 21

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