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Shubhangini Kataruka

@kataruka

Postdoc @ Lesch lab, Yale University. Former @ svobodalab.bsky.social Embryo, chromatin, epigenetics and reproduction.

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Posts 18.03.2025
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Latest posts by Shubhangini Kataruka @kataruka

H3K4me3 amplifies transcription at intergenic active regulatory elements A biweekly scientific journal publishing high-quality research in molecular biology and genetics, cancer biology, biochemistry, and related fields

New paper on the role of H3K4me3 at enhancers! We (led by Haoming Yu) used dCas9 epigenome editing to add H3K4me3 to intergenic enhancers. This was (1) sufficient to turn up transcription at open, active regions and (2) has no effect on target gene transcription. genesdev.cshlp.org/content/earl...

20.08.2025 01:28 👍 84 🔁 33 💬 3 📌 1
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SMARCA5 restricts chromatin accessibility to promote male meiosis and fertility in mammals | PNAS Establishment of correct chromatin configuration in male meiosis is essential for sperm formation and male fertility. However, how chromatin remode...

Truly a team effort from the Lesch lab @ambystoma22.bsky.social Happy to share this paper where we study the role of Smarca5 in spermatogenesis.
www.pnas.org/doi/10.1073/...

01.08.2025 18:05 👍 11 🔁 4 💬 0 📌 1

Thanks Pratyush ☺️

28.05.2025 00:05 👍 0 🔁 0 💬 0 📌 0

So excited to be part of this exceptional group of scientists!

27.05.2025 18:45 👍 4 🔁 1 💬 0 📌 0