New paper showing that much of the apparent success of protein language models in predicting mutational effects is a mirage: These models mostly memorize sites. 1/
www.biorxiv.org/content/10.6...
@pcherry
MolBio, tech, & culture enthusiasm outlet. Drinking from the fire hose, shouting into the void. he/him๐จโ๐ฌ๐งฌ๐จโ๐ป๐งโโ๏ธ๐ณ๏ธโ๐ Senior Scientist at BillionToOne in R&D, working on all things NGS, liquid biopsy, and bioinformatic https://pcherry.io/
New paper showing that much of the apparent success of protein language models in predicting mutational effects is a mirage: These models mostly memorize sites. 1/
www.biorxiv.org/content/10.6...
Wow convection over the Diablo range in...*checks calendar*.... February?
46.2/50. I remember colors better than I remember names. Come at me. dialed.gg?c=E965V4
A new systematic analysis of intermittent fasting from 22 randomized trials shows no advantage for weight loss or other outcomes compared with regular diet advice
www.cochranelibrary.com/cdsr/doi/10....
@kairyssdal.bsky.social here is the second person ever to mention Ottumwa, Iowaโeverโin my life.
infosec.exchange/@josephcox/1...
the cool part about the Dumbarton Bridge is you can bike from Union City BART along Alameda Creek and all the way out on the levee trails and just kind of be in the middle of the bay hanging out
Iโm not actually watching but I cannot stop my self from saying this:
They should show the Dumbarton Bridge
Thereโs a phenomenon rarely discussed or valued in American society that is worth its weight in figurative and literal gold: the practical benefits and advantages of being a Dependable, Pleasant, and Helpful person. I have and continue to reap tangible benefits from my dad being a good person
When the Guinea worm eradication program began in 1986, there were an estimated 3.5 million cases across 21 countries in Africa and Asia.
There is far more outrage from tech leaders over a wealth tax than masked ICE agents terrorizing communities and executing civilians in the streets. Tells you what you need to know about the values of our industry.
OpenAI exec James Dyett calling out the cowardice
From pandas 3.0.0, released 2 days ago.
Stop authenticating by SMS. It is insecure for multiple reasons.
If your website / service does this, give users the option to disable it for their account.
arstechnica.com/security/202...
The choice that matters isn't Tamiflu vs Xofluza. It's today vs tomorrow. Same-day flu treatment was associated with 64% lower mortality. Drug selection? Similar outcomes.
More than 48 hours into the PG&E meltdown & most of the Muni subway is still down. Right as people get ready for the holiday.
Itโs outrageous & unacceptable. Itโs time for serious accountability. Itโs time for San Francisco to break away from PG&E & create a public utility.
The Sunset is dark & quiet during the blackout.
Pedestrians are using flashlights to get around & restaurants have closed early. Kitchen staff are taking the bus or scootering home.
Patrons are dining by candlelight.
Elsewhere, Waymos are stuck, snarling traffic.
Wash, rise, repeat. ๐ซ๏ธ
Tule fog blankets Central Valley, Bay Area. What day is this now?
Love how waymos will just like block the bus for 5 minutes
Quick update on #openenrollment HDHPs / HSAs: benefits from employers seem to be broadly getting worse. And this has implications for whether an HDHP will pay off.
pcherry.io/posts/2025_1...
Email from Capital One: If youโre traveling internationally, here are a few things you can do to prepare. BEFORE YOU GO: Research which payment methods are most common in your travel destinationโacceptance may vary from before. Check out these resources to help you plan. Bring a second form of paymentโcash or a credit cardโjust in case. WHILE ABROAD: Look for the Discoverยฎ, PULSEยฎ or Diners Club Internationalยฎ logo at merchants and ATMs. Your debit card should work at any of these locations. Try your cardโeven if you donโt see a logo, your card may still work.
Imagine buying a payment card network that has a low acceptance rate, especially abroad, and explaining to customers that they should lower the expectations but try anyway
โNicknameโ is not โnickโ + โname.โ
It was originally โekename.โ
โEkeโ was the Middle English word for โalsoโ or โin addition.โ
Since โekenameโ began with a vowel, people used โanโ before it.
Over time, 'an ekename' became 'a nickname.'
As you all know, I have written about the utility of HSAs (health savings accounts): https://pcherry.io/posts/2024_01_02-why_you_should_elect_a_hdhp
Also, NYT has reported on new healthcare costs that are eligible for payment from an HSA: https://archive.ph/oY5b6
PSA: as you think about open enrollment for next year, Morningstar published a review of the common HSA (health savings account) providers [โฆ]
For general purpose tidying up the web, I use CookieAutoDelete, which has great setting to keep or discard cookies based on website, patterns, etc.
For all other web nonsense, I use uBlock Origin in Waterfox browser to stop them from displaying.
github.com/Cookie-AutoD...
+1 for Consent-O-Matic for auto GDPR cookie and provacy pop-over completion. It works effectively and wicked fast on most websites.
github.com/cavi-au/Cons...
From a new @thelancet.com article today entitled "Health care in the USA: money has become the mission" www.thelancet.com/journals/lan...