@graillelab
The GrailleLab is interested in understanding how RNA post-transcriptional and/or protein post-translational modifications are written, erased and read as well as how they influence mRNA decoding by ribosome for protein synthesis.
Job alert: full-time researcher position for AI with CNRS here in France. Initial contract for 5 years (tenure track). Attractive starting package and better salary than regular positions. I have been w/ @cnrs.fr since 2013, it's great!
Applications due 31/03
www.ins2i.cnrs.fr/en/cnrsinfo/...
Postdoc positions on nuclear RNA biology available in the Heick Jensen lab. Come join us in tiny Denmark. Interested? - then follow this link: mbg.au.dk/aktuelt/ledi...
2 positions open at @cbm-upr4301.bsky.social in #Orléans :
- Engineer in cell biology : emploi.cnrs.fr/Offres/CDD/U...
- Post-doc in conjugation and analytical chemistry :
emploi.cnrs.fr/Offres/CDD/U...
Pas sûr qu'ils atteignent 25% des labos avec ces critères. Ils pourront faire encore plus d'économies. C'est Bercy qui va être content de ces bons élèves...
Welcome
@omuhlemann-lab.bsky.social
#RNA #NMD #translation
We are pleased to share our work on the evolution of translation initiation now published in Nature Communications. Take a look at leaderless mRNAs and eS26 in the small ribosomal subunit of Saccharolobus solfataricus. rdcu.be/d5pgg
Une ouverture pour un poste de professeur en biochimie au sein de notre équipe ! Consultez l'offre : www.univ-orleans.fr/upload/publi... Vous pouvez me/nous contacter pour toute question.
1. I feel like this is such obvious advice that it gets taken for granted & consequently no one says this to young scientists but READ PAPERS, read all the papers. As you move up in your career you will have less & less time to do this. Read everything that appeals to you not just in your field
We are looking for new group leaders. If RNA is your thing, and/or computational biology and you want to start your own group, check out these links. Feel free to contact me about these!
And, please help me spread this. Thanks!
www.imb.de/jobs/jobdeta...
www.imb.de/jobs/jobdeta...
L´ingénieur viendra renforcer notre unité et en particulier mon équipe www.ferreiracercalab.com.
Merci de partager cette information.
Pour tous renseignements complémentaires, n´hésitez pas à nous solliciter.
Bonjour, nous avons un poste d´IE en biochimie et biologie moléculaire ouvert en mobilité interne (FSEP) au laboratoire de biologie structurale de la cellule (BIOC) située au sein de l´École polytechnique (Palaiseau) .
emploi.cnrs.fr/Offres/MOBIN...
AF3 BEST METHOD followed by cluspro but also some conversion errors
Happy to share the website of RiboMod2025, the "Conference on Ribosomal RNA modifications and snoRNAs" in Bologna June 12-13, 2025 is up at events.unibo.it/ribomod2025
Stay tune for more infos!
#RNA #Ribosome #snoRNA #Eiptranscriptomics
📣📣📣
Come join us and set up your team in the I2BC Cell Bio Dept!
You will find great science, diverse topics and models, spacious labs, supportive environment, and fun colleagues. We are a short (train) ride south of Paris.
Please DM me with any questions and help us spread the word 🙏
Cool initiative. Could you please add my lab to this list? Thanks
This project was done in collaboration with the groups of Hervé LE HIR (IBENS, Paris) and Cosmin Saveanu (Institut Pasteur) with the support from ANR (Agence nationale de la recherche), CNRS, École Polytechnique and Fondation ARC pour la recherche sur le cancer.
Altogether, these results suggest that, during evolution, a general mechanism has been preserved to ensure the correct decay of aberrant mRNAs containing premature stop codons or transcripts with long 3’-UTRs.
This UPF1-SMG6 interaction turns out to be important for the optimal degradation of NMD substrates in human cells. These data demonstrate that the Upf1-Nmd4 interaction is conserved in human, reinforcing the existence of a universal mechanism for the NMD pathway.
We show that this region is important for the previously described phospho-independent interaction of the human SMG6 protein with the helicase domain of UPF1 and binds in a very similar way as yeast Nmd4 to UPF1 helicase domain.
We also show that Nmd4 activates the ATPase activity of Upf1 and increases its affinity for RNA. Interestingly, we identify a region similar to yeast Nmd4 C-terminal arm in metazoan SMG6, the main enzyme that initiates RNA degradation in metazoan NMD.
This article describes the crystal structure of the complex formed between the S. cerevisiae Nmd4 protein and the helicase domain of the Upf1 protein. This structure reveals that Nmd4 interacts with Upf1 helicase core through a conserved C-terminal arm.
Very happy to share our new publication on the interaction between two nonsense mediated mRNA decay factors (Upf1 and yeast Nmd4 or human SMG6). 🍾
journals.plos.org/plosbiology/...