Mehdi Farokhnia

Diagram showing the effects of GLP-1 therapies and ASUDs on the human body. "Beneficial effects" includes glucose regulation, metabolic homeostasis, appetite, and weight loss. "Open questions" include dose/duration and interindividual variability. "Safety considerations" includes muscle loss.

#GLP1 receptor agonists demonstrate potential for reducing alcohol and nicotine use in patients, but further randomized studies are required before clinical adoption for addiction.

ja.ma/49SiueP

GLP-1 Therapies for Addiction and Mental Health Comorbidities This narrative review discusses the current landscape of glucagon-like peptide-1 therapies in the context of alcohol and other substance use disorders, mental health considerations, and gaps and oppor...

🚨 Prospects of GLP-1 Therapies for Addiction and Mental Health Comorbidities—Quo Vadis?

jamanetwork.com/journals/jam...

@jamapsychiatry.com

Excited about this today ✨
#ACNP2026

Figure 3 from the paper “Plasma concentrations of the inflammatory adipokine lipocalin-2 are not affected by chronic alcohol exposure in rats or acute alcohol administration in people with alcohol use disorder”

A study at NIDA/NIAAA by @rani-richardson.bsky.social and @mehdifarokhnia.bsky.social examined an inflammatory molecule LCN2 in people w/ AUD and alcohol-dependent rats. Time-based differences in LCN2 levels were observed in rats but not humans. Learn more here: www.tandfonline.com/doi/full/10....

New Chapter ✨

GLP-1s show promise in treating alcohol and drug addiction A popular class of therapies for treating diabetes and obesity may also have the potential to treat alcohol and drug addiction, according to a new paper published in the Journal of the Endocrine Socie...

GLP-1s show promise in treating alcohol and drug addiction www.endocrine.org/news-and-adv...
@endocrinesociety.bsky.social

GLP-1, ACNP, and Bahamas - not bad, not bad 😎 @acnporg.bsky.social #ACNP2026

Excited to talk GLP-1 and addiction this weekend! Thanks Endocrine Society for the invite ✨

Glucagon-like peptide-1 receptor agonists but not dipeptidyl peptidase-4 inhibitors reduce alcohol intake Glucagon-like peptide-1 receptor agonists but not dipeptidyl peptidase-4 inhibitors reduce alcohol intake

NIDA IRP Featured Paper of the Month – July 2025

irp.nida.nih.gov/featured-pap...

#RSA2025 #RSA_ISBRA2025

Anecdotal reports and animal studies suggest that drugs like Ozempic reduce alcohol consumption.

@mehdifarokhnia.bsky.social et al. now present a pharmacoepidemiologic study examining showing GLP-1RAs but not DPP-4 inhibitors reduce alcohol intake: buff.ly/BjP1kRB

Utilizing Blood Inflammatory Markers in Alcohol Studies: Considerations and Recommendations for Study Design, Sample Collection, and Data Analysis A large body of evidence suggests that heavy alcohol use is associated with dysregulated immune function, and that immune dysfunction in turn contribu…

🚨 Utilizing Blood Inflammatory Markers in Alcohol Studies: Considerations and Recommendations for Study Design, Sample Collection, and Data Analysis

www.sciencedirect.com/science/arti...

Convergent findings across humans, including real world data, as well as studies in mice, and rats indicate that GLP-1RAs but not DPP-4Is reduce alcohol consumption and may be efficacious in treating alcohol use disorder @jclinical-invest.bsky.social www.jci.org/articles/vie...

My favorite 💚

The @NASEM_Health hosted a public workshop in September 2024 to explore the science and research gaps in the mechanisms of action of GLP-1R agonists in the brain. Read the Proceedings of a Workshop here (2/2): www.nationalacademies.org/our-work/exa...

Beyond weight loss and diabetes treatment, glucagon-like peptide-1 receptor (GLP-1R) agonists show promising clinical benefits for patients with eating disorders, neurodegenerative diseases, substance use disorders, and pain. (1/2)

a man in a suit is dancing in front of a choir with the words hallelujah glooray written above him ALT: a man in a suit is dancing in front of a choir with the words hallelujah glooray written above him

The world is falling apart, but big paper accepted, so:

#NIH #NIHproud #SupportNIH