Juan I. Bravo, PhD

Another group following up on the work from my PhD, linking LINE-1 transposon expression to aging phenotypes!

🥳 Excited to share that our multi-omic study on the cellular impacts of Alu overexpression in healthy fibroblasts, co-led by former trainee Dr. Juan Bravo @the-te-guy.bsky.social and grad student Ms. Eyael Tewelde is out today in #Geroscience! 🧬🧪🖥️ #GeroSky
A 🧵 1/4
link.springer.com/article/10.1...

A multi-omics analysis of human fibroblasts overexpressing an Alu transposon reveals widespread disruptions in aging-associated pathways https://www.biorxiv.org/content/10.1101/2025.07.11.664466v1

A multi-omics analysis of human fibroblasts overexpressing an Alu transposon reveals widespread disruptions in aging-associated pathways During aging and cellular senescence, repetitive elements are frequently transcriptionally derepressed across species and cell types. Among these, the most abundant repeats by copy number in the human...

🚨 Another preprint from the lab out today! 🚨
This work led by former trainee Dr. Juan Brado @the-te-guy.bsky.social and new grad student Ms. Eyael Tewelde, to undertstand how upregulation of a single retrotransposon (here, AluJB) impacts cellular phenotypes! A 🧵, 1/9
www.biorxiv.org/content/10.1...

✨✨ #GLAM2025 ✨✨ is back 9/5/2025 to showcase #geroscience trainee research! Registration and poster submission are open (and #FlashTalk selection for #undergrads!).
Event website: gero.usc.edu/laara/event/...
Thanks to @activemotifusa.bsky.social, #Hevolution and #VWR for their support!

Leveraging long-read assemblies and machine learning to enhance short-read transposable element detection and genotyping Transposable elements (TEs) are parasitic genomic elements that are ubiquitous across the tree of life and play a crucial role in genome evolution. Advances in long-read sequencing have allowed highly...

First up is @adaigle.bsky.social's preprint where we use Drosophila genomes that have been sequenced with both short and long reads to train a machine learning method to more accurately detect and genotype transposable element insertions: doi.org/10.1101/2025...

Polymorphic transposable elements contribute to variation in recombination landscapes (drosohila 🪰) www.pnas.org/doi/full/10.... #TEsky

Great to see it formally published! 🎉

Glad to share that the final version of this study just came out in #TranslationalMedicineOfAging!
Congrats to @the-te-guy.bsky.social aka Dr. Juan Bravo for this proof-of-principle study showing that GWAS tools can be used to identify candidate #L1 regulators!
www.sciencedirect.com/science/arti...

Thank you for hosting, thanks to everyone that came, and thanks to the lab more generally! It was very much appreciated and it was great to see and hangout out with a very amazing and fun group of people, not just today but also over the last few years!

Genome-wide maps of highly-similar intrachromosomal repeats that can mediate ectopic recombination in three human genome assemblies doi.org/10.1016/j.xh...

Header of the BiorXvi preprint

Shareing the #Benayoun lab’s newest preprint (>2 months ago - I'm new to Bluesky 😅), where we use #1000GenomesProject data to identify putative regulatory loci of #LINE1 and #Alu copy numbers in diverse human populations, led by the talented Dr. Bravo 🧬 🖥️. A 🧵. 1/8 biorxiv.org/cgi/content/...