Sounds good, but, we also consider suitable area for high-resolution Cryo-ET.
11.03.2026 08:02
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Sounds good, but, we also consider suitable area for high-resolution Cryo-ET.
Figure 1. Cryo-EM of abundant protein complexes in native membranes.
Figure 2. Cryo-EM of membrane proteins in vesicles.
Figure 3. 3D reconstruction of V-ATPase in native synaptic vesicle membranes.
Figure 4. Generation of membrane vesicles for structure determination of proteins in their native lipid bilayer.
I've written a review on what I think is an extremely exciting direction in cryo-EM:
Cryo-EM of endogenous membrane proteins in their native lipid bilayer
Open access in Quarterly Reviews of Biophysics:
doi.org/10.1017/S003...
We found a viral Trojan Horse: a virus can hide inside another virus.This one surprised us: deltaviruses donβt just borrow a helper virus. They can travel inside it.
A literal Trojan Horse βvirus-in-a-virusβ route into cells. π€― Kudos to 1st author @viroscope.bsky.social and co-authors !
A research team from the Max Planck Institute for Multidisciplinary Sciences, the Institut Pasteur, and EMBL has shown in a Nature paper how the influenza polymerase, a molecular thief, uses the host RNA to replicate.
Check out the MPI press release: www.mpinat.mpg.de/5179649/pr_2...
Apply now! @vbcscitraining.bsky.social offers more than 25 fully-funded PhD positions! GMI group leaders are also recruiting new students.
ππ π°πΆππΆπ»π΄ ππ²ππ²πΉπΌπ½πΊπ²π»ππ πΆπ» π πΆπ°πΏπΌππ°πΌπ½π π₯π²π½πΌπΏππΆπ»π΄! If you're involved in creating, processing, or publishing microscopy data, take a look at the new checklist for reporting requirements provided by @quarep-limi.bsky.social in @jcb.org π rupress.org/jcb/article/...
This immunogen is cheap and easy to produce and elicits a high quality antibody response. Project led by @nawsadalam. Read all about it:
link.springer.com/article/10.1...
We have started a project trying to predic the interactions/structures of all yeast protein pairs using an AlphaFold pooling approach. We are making the current dataset open and we welcome collaborations.
www.evocellnet.com/2026/03/mapp...
The new Vienna BioCenter Interdisciplinary Postdoctoral Program (VIPΒ³) is here! We have 8 fully-funded positions for scientists with a PhD in biology, chemistry, physics, bioinformatics etc.
The call is open!
More information: training.vbc.ac.at/post-docs/vi...
#VBCPostDoc
Now online! High-resolution in situ structures of hantavirus glycoprotein tetramers
ChimeraX screenshot showing CubeNTube plugin.
The new ChimeraX CubeNTube plugin allows erasing parts of maps using cube, cylinder, and custom shapes and has undo. Created by Tamino Cairoli. Available from ChimeraX menu Tools / More Tools....
Study from a team of Canadian and German researchers has uncovered never-before-seen details about what happens to proteasomes, the cellβs garbage disposal system, when there is not enough energy. bit.ly/3OGywRX
Your airways and your gut are high-traffic areas for the microbes of the world. π¦
For more than 40 years, LJI's Mitchell Kronenberg has studied the T cells that step up to defend our most vulnerable organs.
Now Kronenberg has been elected fellow of the AAM: bit.ly/4rBrcps
@asm.org #microbiology
βCompared to the reduction at the national level, the large declines in cervical cancer incidence observed in several states were very encouraging"
Cancer rates decreased in states with the highest HPV vaccination rates - #MedSky + #OncSky + #ReproSky.
pressroom.cancer.org/declines-in-...
Nice #alphafold
Tried it. Its awesome. Shame the code isn't available. Webserver only, how long will it last??
Long in the making, but happy to present the Chlamydomonas chlororibosome!
Cryo-ETπ¬reveals a large new domain on the small subunit, built from multiple extensions in conserved ribosomal proteins.
bioRxiv π: shorturl.at/q44tG
This suggests greater chlororibosome diversity than expected!
1/n π§΅
I've been working on Surface Morphometrics for a new version (coming soon), and made some significant (AI-assisted) performance improvements, especially in pycurv (20-50x!). If you've had technical issues or just felt like it was too slow, give it another try! #teamtomo github.com/GrotjahnLab/...
π CryoSPARC v5.0 BETA is here!
Weβre excited to deploy another major #CryoSPARC release to help enable and accelerate #cryoEM data analysis. v5 has a redesigned underlying software system and many new features - highlights in thread!
Full changelog: cryosparc.com/updates/v5.0.0
We are running the cryo-ET image processing workshop again this year! Come learn everything tomo: STA, segmentation, heterogeneity analysis from @baradlab.com @williamnwan.bsky.social and others!
Apply!
A super detailed protocol + video on Cryo-ExM - Cryo-Expansion Microscopy, led by the labs of our former postdocs @marinelap.bsky.social & @ebertiaux.bsky.social.
Clear, practical, and very useful for anyone doing nanoscale imaging π app.jove.com/t/68595/expa...
Recruitment for the EMBL International PhD Programme is officially open! π
At EMBL, we train young scientists to become skilled and creative future leaders in academia, industry and other sectors. Start your career in the life sciences with us!
π Read more here:
tinyurl.com/4jdt2ra5
SHAPES being the key word, amirite @nanigrotjahn.bsky.social
github.com/GrotjahnLab/...
Should be an interesting #TeamTomo talk. Check it out! π§ͺ π¬
Everyone should read this!
π§ͺ #AcademicSky
When two years of academic work vanished with a single click
www.nature.com/articles/d41...
Mechanism of membrane perforation in rotavirus cell entry www.biorxiv.org/content/10.64898/2026.01.21.700916v1 #cryoEM
π Last call to apply!
Amgen Scholars Program 2026 β Institut Pasteur
π
Jul 6βSep 5 β β³ Deadline: Feb 1
Marcel Nos Llorens, PhD student & former Amgen Scholar, says: βGo for it! Itβs a unique chance to gain hands-on research experience and step toward a career in science.β π¬
π© Apply: bit.ly/4t0PdaH
PDB 7jsn colored by DAQ scores of fit in cryoEM map.
The ChimeraX DAQplugin computes DAQ scores showing the agreement between atomic models and cryoEM maps. Available from ChimeraX menu Tools / More Tools. cxtoolshed.rbvi.ucsf.edu/apps/chimera...
Antigenic landscape of rabies and related lyssaviruses revealed by cryo-EM https://www.biorxiv.org/content/10.64898/2026.01.14.699513v1
Epstein-Barr Virus #EBV was linked to #MultipleSclerosis - now a plausible cause has been found, misidentification by longterm memory T-cells that pick on the wrong protein, ANO2, instead of the EBV-antigen. Massive inflection towards the elimination of MS!!!
π§ͺπ§ Cell www.cell.com/cell/fulltex...
Incredible resource for #teamtomo. Congratulations and thank you for all involved πππ
