Roser TP

S-TIR-ring up TLR7 and TLR9: signaling domain substitutions clarify the TLR paradox: www.jci.org/articles/vie...

@rosertp.bsky.social & @carovinuesa.bsky.social provide a Commentary on Claire Leibler et al.: www.jci.org/articles/vie...

Extremely thankful to get the opportunity to present my work at the WIRM! #WIRM2025

Frontiers | Deep sequencing of BCR heavy chain repertoires in myalgic encephalomyelitis/chronic fatigue syndrome

Our new publication on BCR sequencing in ME/CFS, adding to the evidence of an increased usage of IGHV3-30.

Much more immunological research is needed to understand the many lines of evidence indicating immune-mediated or autoimmune components to the disease.

www.frontiersin.org/journals/imm...

Tejedor Vaquero, Neuman et al. @gmagrilab.bsky.social demonstrate immunomolecular and reactivity landscapes of gut IgA subclasses in homeostasis and inflammatory bowel disease. https://buff.ly/4jVJYV5

📘 In Host–Microbe Interactions 2025 👉 https://buff.ly/40XMv8r

McClure, @hepworth-lab.bsky.social, Konkel et al. outline a Th17-to-Tfh plasticity during #periodontitis that is protective and limits periodontal pathology. https://buff.ly/41fwVq4

📘 In Host–Microbe Interactions 2025 👉 https://buff.ly/40XMv8r

Time of day of vaccination does not influence antibody responses to pneumococcal and annual influenza vaccination in a cohort of healthy older adults - PubMed Vaccines are less immunogenic in older adults, partly due to immunosenescence. Having previously shown that morning influenza vaccination may be more immunogenic in older adults (mean age 71), we…

Wondering if you should get up early for your vaccine for the best immune response? Kai-Michael Tollner's recent paper with the University of Birmingham says don't bother if you're under 60!

Editors resign from Springer immunology journal to launch nonprofit title Several top editors of the Journal of Clinical Immunology, a Springer Nature title, have jumped ship to start a new, nonprofit journal with Rockefeller University Press.  Jean-Laurent Casanova…

Grateful to see @retractionwatch.com share our story! Learn more about the launch of Journal of Human Immunity, why our editors made the move, and what’s next for our nonprofit journal with @rupress.org. Insights from our EiC @casanovalab.bsky.social here: retractionwatch.com/2025/02/06/e...

Our very own Laura Shuttleworth talked about her brilliant research last night at the @crick.ac.uk for Sofar Sounds, sharing the stage with musicians and poets, and bringing science closer to society.

Yaaaay well done, congrats 🥳🥳 Have fun in your postdoc ☺️

Are you a parent? Or caring for another adult, relative, friend? And are you a UK-based #academic? 🧪
We recently ran a survey (www.qualtrics.manchester.ac.uk/jfe/form/SV_...) to capture lived experiences - if you didn't complete the survey at the time, please do now. Please share w/ colleagues

News at a glance: Oldest continuous ice core, formaldehyde's risks, and building Africa's science workforce The latest in science and policy

Working in Antarctica, scientists have drilled the world’s oldest continuous ice core, 2690 meters long and holding an unbroken history of the atmosphere going back 1.2 million years.

Learn more in this week’s News at a glance. ⬇️

Hyperreactive B cells instruct their elimination by T cells to curb autoinflammation and lymphomagenesis Aberrant immune signal strength in B cells is associated with autoimmune diseases and lymphoma. Diehl et al. show that hyperreactive B cells trigger cytotoxic T cell-mediated elimination. Less reactiv...

This is a super interesting (IMO) study on how T cells can repress out of control B cell responses, particularly relevant to autoimmunity and lymphomagenesis #Immunosky #lymphomasky
www.cell.com/immunity/ful...

We’re thrilled to announce our partnership with the International Alliance for Primary Immunodeficiency Societies (#IAPIDS) to launch the Journal of Human Immunity (JHI) @jhumimmunity.org (https://buff.ly/3PAEMrK)! Groundbreaking, #OpenAccess research on #HumanImmunity 👉 https://buff.ly/4ajqm8W

Pathogens and planetary change - Nature Reviews Biodiversity This Review explores the relationship between emerging infectious diseases and biodiversity loss, and how both are connected to global environmental changes in the Anthropocene.

There's a lot of replies to our new paper talking about how capitalism or overpopulation are the real enemy. Without getting into whether that's true of the climate emergency or the sixth mass extinction (🙃), I want to briefly explain why pandemics are different. www.nature.com/articles/s44...

David Lynch, Twin Peaks and Muholland Drive director, dies aged 78 Film-maker who specialised in surreal, noir style mysteries made a string of influential, critically acclaimed works including Wild at Heart and Eraserhead David Lynch, the maverick American director who sustained a successful mainstream career while…

David Lynch, Twin Peaks and Muholland Drive director, dies aged 78

Earth breaches 1.5 °C climate limit for the first time: what does it mean? The threshold has been exceeded for only one year so far, but humanity is nearing the end of what many thought was a ‘safe zone’ as climate change worsens.

Bad news for climate just announced! In 2024, Earth's average temperature temporarily exceeded 1.5°C above pre-industrial levels for the first time. This breach highlights accelerating climate risks - toward the end of the "safe zone" defined by the Paris Agreement.🧪🌐🌍
www.nature.com/articles/d41...

Migratory dermal gamma delta T cells determine the balance between lung immunity and tissue damage during Nippostrongylus brasiliensis infection Many helminth parasites migrate through multiple host organs during infection but how immunity is regulated across these tissues is still poorly understood. To investigate the cellular and molecular a...

What a great way to start this account and end the week: our preprint describing how dermal γδ T cells mediate a skin-lung axis during parasite infection in mice is online! I'm excited to show the findings of my main postdoc project with @profjudiallen.bsky.social!🧵👇
www.biorxiv.org/content/10.1...

Table graphic of the monthly global sea-ice extent from January 1979 through December 2024. Colours and cell numbers show the rank by month; blue shades (and higher numbers) show a larger ice extent, and red shades (and lower numbers) show a smaller extent. Source: OSI SAF sea-ice index v2.2

Global sea-ice extent ranked by month from 1979 through 2024.
Nothing blue since since 2015!
Within the recent nine years, every month has experienced a record-low extent.
🌊🧪⚒️📉

AI Needs So Much Power, It’s Making Yours Worse There’s a strong link between proximity to AI data centers and higher levels of distorted power in residential areas

AI data centers are multiplying across the U.S. and sucking up huge amounts of power.

New evidence shows they may also be distorting the normal flow of electricity for millions of Americans

Not only will this create a network effect, but because bioRxiv is intended to be an enabling platform that stimulates evolution, it will allow _other people_ to do great things e.g. connect.biorxiv.org/news/2021/05... 2/2

Photo of the Vinuesa lab members by the sea.

Hi 👋🏼 The Vinuesa lab has arrived at BlueSky! Follow us if you want to talk about all the exciting science going on in autoimmunity, genetics, and anything B cell-related 🧬 🧪

Color blind friendly palettes for data visualizations with categories A discussion of color blind friendly palettes for labeling unique catergories in data visualization.

Having a color-blind colleague is a good reminder that we need to be more careful when designing figures for scientific publication 🧪
My lab has found this page especially useful for selecting color palettes, used in combination with different symbols: thenode.biologists.com/data-visuali...

📌"Pas de gegant per entendre la causa de l' #autisme més comú"

📰 @ara.cat

✍️ @crisaez.bsky.social

➡️ shorturl.at/1Dztj

#IRBScience #Autism @xsalvatella1.bsky.social

(Bicentenary) ILC interactions with the extracellular matrix in inflamed barrier tissues at The University of Manchester on FindAPhD.com PhD Project - (Bicentenary) ILC interactions with the extracellular matrix in inflamed barrier tissues at The University of Manchester, listed on FindAPhD.com

New PhD opportunity in the lab with @profjudiallen.bsky.social and @douglaspdyer.bsky.social looking at interactions between ILCs and the extracellular matrix. Application deadline Jan 10th 2025 - spread the word Bluesky immunologists!
www.findaphd.com/phds/project...

(International Partnership Studentship) Defining an atlas of tissue-resident lymphocytes in the gut immune microenvironment at The University of Manchester on FindAPhD.com PhD Project - (International Partnership Studentship) Defining an atlas of tissue-resident lymphocytes in the gut immune microenvironment at The University of Manchester, listed on FindAPhD.com

PhD opportunity in my lab together plus collaborative placement with Jenny Mjosberg's group at Karolinska. Looking for someone with a passion to learn and develop spatial 'omics pipelines in the gut. Deadline end of the week! Spread the word:
www.findaphd.com/phds/project...

go.bsky.app/7zMmwNY

Hi all, so nice to cross over to the light. Here is a starter pack for all things Mucosal Immunology! Exciting to create a MI community here. Let me know if you would like to join 👍

Periodic reminder: a lot of what makes AI "work" is exploited people doing the tasks, just hidden behind fancy websites.

It's good that a normie outlet like 60 Minutes is reporting on this.

The human proteomic revolution proceeds with high-throughput assessment, AI analytics, correlation with health and disease, drug interactions, biomarkers
www.cell.com/cell/fulltex...

Gut IgA1 and IgA2 subclasses co-emerge early in life, largely derive from clonally related and somatically mutated plasma cells in adults, and show unique changes of both frequency and reactivity in IBD @gmagrilab.bsky.social
doi.org/10.1084/jem....