A team led by Ludwig @unil.bsky.social’s @lbejarano.bsky.social & @johannajoyce.bsky.social has discovered that a protein made by cancer cells, CD13, helps them establish colonies in the brain—identifying a potential drug target for the prevention or treatment of brain metastases. bit.ly/4afX64r
Tumor-derived CD13 helps cancer cells colonize the brain
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Led by @lbejarano.bsky.social w/ many wonderful collaborators in @joycelab.bsky.social and in Lausanne 🙌
@cp-cellreports.bsky.social
@fbm-unil.bsky.social
@unil.bsky.social
@ludwigcancer.bsky.social
Article: www.cell.com/cell-reports...
Why do so few cancer cells manage to form metastases - and what helps the rare ones succeed?
Delighted to share our first publication of 2026 🎉🎉, led by the outstanding @lbejarano.bsky.social 🤩, where we reveal some insights into this - focusing on brain metastasis 🧠🧪🔬
www.cell.com/cell-reports...
Thanks a lot Johanna for your support and for being an outstanding mentor!
Congratulations to all the ERC Starting Grant awardees 🧪 including @alvarezprado.bsky.social & @lbejarano.bsky.social, two brilliant former postdocs from my lab who have started their own labs this year in 🇱🇺 and 🇪🇸
Could not be more proud of Leire and Ángel 🤩 🎉 🎉 🎉
#proudmentor 😊
#ERCStartingGrant
Thrilled to share that I’ve been awarded an ERC Starting Grant for the METAVASC project, focused on studying the vasculature in brain mets 🙏🎉
Huge thanks to the ERC, mentors & collaborators that made this possible!
We’ll soon recruit PhDs, postdocs & techs, stay tuned😊
@erc.europa.eu #ERCStG
How can we reawaken the body’s own anti-viral defenses to fight brain cancer?
Delighted to share our new study where we now answer this question, led by the brilliant @alvarezprado.bsky.social who is now an independent PI at LIH Luxembourg 👏👏
#BrainTIME 🧠🦠🧪
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www.sciencedirect.com/science/arti...
Truly honored to receive the 'Young Researcher in Basic Sciences Award' from the Faculty of Biology and Medicine, University of Lausanne! 🧠 ✨
Huge thanks to Johanna Joyce for her excellent mentorship, support, and inspiration — I’m incredibly grateful!
And congrats to all the other awardees! 🎉
After a memorable journey in the Joyce Lab, it’s time to start a new adventure. I will always be grateful for the extraordinary mentorship and support of @johannajoyce.bsky.social. I'm excited to share that I will start as a #NewPI at the Biogipuzkoa HRI, in the beautiful city of San Sebastián 🙂
The unveiling of vascular heterogeneity is depicted as a red pencil coloring in the intricate details of tumor-associated blood vessels within a map of the human brain wherein a tumor is surrounded by diverse immune cells.
New issue online! This beautiful cover depicts work from @johannajoyce.bsky.social @lbejarano.bsky.social
&co who use single-cell RNA sequencing & spatial analysis to construct a vascular atlas of primary & metastatic brain tumors. Art by @joanagcc.bsky.social
www.cell.com/immunity/iss...
On the cover: The blood-brain barrier is a defining feature of brain tumors, shaping their biology and therapeutic response. In this issue, Bejarano et al. use single-cell RNA sequencing and spatial analysis to construct a vascular atlas of primary and metastatic brain tumors, revealing distinct alterations in endothelial and mural cells. Glioblastomas undergo substantial vascular remodeling compared to low-grade gliomas, while brain metastases exhibit even greater permeability and increased immune cell interactions. This unveiling of vascular heterogeneity is depicted as a red pencil coloring in the intricate details of tumor-associated blood vessels within a map of the human brain wherein a tumor is surrounded by diverse immune cells. Image by Joana C. Carvalho.
Excited to see our image on the cover of #Immunity today 🤩
Congrats to the amazing @lbejarano.bsky.social & all authors for our #brain #tumor #vasculature study
www.cell.com/immunity/ful...
Huge 🙏 🙏 to the v talented @joanagcc.bsky.social for creating this super cover 🧠🧪
@cp-immunity.bsky.social
Why do brain metastases resist #immunotherapy — even when the same cancer responds outside the #brain? 🧠🧪💥
We just published a study diving into this question ⏬
Led by an amazing (former) PhD student in my lab —Vladimir Wischnewski 🎉
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@cp-cellreports.bsky.social
www.cell.com/cell-reports...
Study led by Ludwig @fbm-unil.bsky.social’s @johannajoyce.bsky.social and alumnus Vladimir Wischnewski explains why brain metastases of breast cancer are likely to resist potentially synergistic combinations of radiotherapy and checkpoint blockade #immunotherapy. Learn more: bit.ly/4kZTKGo
#CanSky
How does the #vasculature regulate #immune cell infiltration & function across different brain tumors? 🧠🧪
Excited to share our latest study in #Immunity where we uncover some interesting answers— led by the amazing @lbejarano.bsky.social 🤩👏🏻
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@cp-immunity.bsky.social
www.cell.com/immunity/ful...
Thrilled to see our vascular atlas across primary and metastatic brain tumors finally out in Immunity! 😍 🍾
Thanks to @johannajoyce.bsky.social for her invaluable mentorship and to all the authors involved! 🎉
