Thomä lab

How DNA packaging controls the “genome’s guardian” Our cells tightly pack DNA into structures called nucleosomes, which protect DNA but also hide important sites. The key cancer-fighting protein p53 can still access these hidden sites, especially at n...

Our cells pack DNA into tiny bundles that hide important parts. Researchers at the FMI and EPFL found this packing affects how the cancer-fighting protein p53 works, revealing new insights into cancer. www.fmi.ch/news-events/...

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@deyasinic.bsky.social
Thanks for all the support! #EPFL @fmiscience.bsky.social @erc.europa.eu @snsf.ch @krebsliga.bsky.social

Congrats to all the authors on our latest work! We reveal how p53 interacts with chromatin and show, via ubiquitin-related factors USP7 and E6-E6AP, that only specific cofactors can co-reside on nucleosomes together with p53.
tinyurl.com/2feuezvj
@csandate.bsky.social
@deyasinic.bsky.social

Primed for degradation: How weak protein interactions enable molecular glue degraders Molecular glues are small drug-like molecules that induce de novo protein–protein interactions or facilitate pre-existing weak interactions between pr…

📝 🚨 Review alert from the Thomä Lab

@alexanderhanzl.bsky.social, Stefan and Clara collected their thoughts on recent molecular glue degrader modalities. Packed with computational predictions, mutations mimicking glues, bivalent engagement and a discussion on mode of action.
tinyurl.com/mpmbuuky