Joachim Weischenfeldt

Clonal evolution and transcriptional plasticity shape metastatic dissemination routes in prostate cancer - Nature Communications | Thorsten Schlomm Metastasis does not begin when we detect it — it begins when tumour evolution selects the cells that will spread. In our new Nature Communications study, we show that prostate cancer is not a uniform...

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Clonal evolution and transcriptional plasticity shape metastatic dissemination routes in prostate cancer - Nature Communications The impact of tumour heterogeneity on metastatic potential in prostate cancer remains poorly understood. Here, the analysis of single nuclei RNA sequencing and whole-genome sequencing from samples fro...

Back-to-back: Integrating single-nuclei RNA-seq and whole-genome sequencing, @joachimwei.bsky.social and his team show how prostate cancer metastasis is shaped by plasticity-driven convergence alongside ongoing clonal evolution, with distinct clones adopting shared transcriptional trajectories.

Joachim Weischenfeldt, Ashani Weeraratna, Karuna Ganesh, Elaine Fuchs, Ana Anderson, and Sheetal Hardikar discussed "Endogenous Mechanisms of Early Onset Carcinogenesis" at #AACRearlyonset25. @jweischenfeldt.bsky.social @ashi-w.bsky.social @karunamdphd.bsky.social @thefuchslab.bsky.social

Great participation and discussions at our PhD course in Cancer Genomics at @bric-ucph.bsky.social organized together with prof Jesper Andersen. Exciting talks and interactions with external speakers incl @ecuppen.bsky.social and @matlupien.bsky.social 🙏💪👇

Heads up: ignore samtools dot org, similarly minimap2 dot com and likely others. It's owned by a known phishing site and while the binaries they offer look valid currently (but note they may be serving us different binaries to others), that could change.

Ie: it's not us (Samtools team)! Be warned

AACR Conference - Rise in Early-Onset Cancers www.aacr.org/meeting/aacr...

So excited to see it out in @science.org. See details below in the 🧵 from stellar former PhD student @bfurtwa.bsky.social.
Many thanks to all involved, especially Blueskyless Nil Uresin and Sabrina Richer and my co-PIs @fabiantheis.bsky.social and @erwinschoof.bsky.social

Revealed: NIH research grants still frozen despite lawsuits challenging Trump order The Trump administration is exploiting a loophole to keep a funding freeze in place, leaving researchers in limbo.

Almost all grant-review meetings under Trump 2.0 remain suspended at the US National Institutes of Health (NIH), preventing the world’s largest public funder of biomedical research from spending much of its US$47 billion annual budget.


https://go.nature.com/4gM6oW4

Opinion | American Science is Under Attack (Gift Article) The Trump administration hobbles research and endangers the public health.

“I’ve spent over five decades as a scientist in academia & the federal government, including as director of the National Institutes of Health. Never before have I seen my profession so politicized as it is now under the Trump administration”
#AcademicSky 🧪
www.nytimes.com/2025/02/14/o...