At least if they are written by natural intelligence, you are helping another human fellow.
11.03.2026 14:45
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At least if they are written by natural intelligence, you are helping another human fellow.
One of the few good news this week
Thanks for sharing Clement, looks super interesting :)
A break "on" or a break "of"? One 'f' away from serious procrastination.
Looks cool, Pedro!
Good luck to all CIHR applicants!
New paper alert: Paralog interference contributes to the preservation of genetic redundancy www.cell.com/current-biol...
Never heard of that. Is that a new hairdo?
Hooking on McDavid and other super fast players is always more tolerated, as if refs wanted to keep the game fair.
It was him vs them, even if he did not score. At moments he looked like the most motivated guy on the ice.
The February issue of #GENETICS highlights a model developed by @christianlandry.bsky.social and colleagues that demonstrates how physical interactions between alleles determine total protein activity and contribute to phenotypic dominance and fitness. buff.ly/qqcNPoO
On veut Desbiens avec les boys demain #goCanadago
A bridge over an ice-covered river
Come visit Québec City in winter, if only to see the longest cantilever bridge floating over an iced Fleuve Saint-Laurent
Go Brazil go!
I have particularly enjoyed recent papers that show how expression levels affect protein evolution in various ways. One of them www.nature.com/articles/s41...
Strategy to generate a DMS plasmid library for Your Favorite Gene (YFG) using short, degenerate libraries. 1. Segmentation of YFG into sub-fragments, each fragment corresponding to a DNA region to be synthesized. The same approach can be applied to promoter and terminator regions, if desired. 2. Example of a pool of degenerate oligonucleotides (oPool) derived from one YFG fragment associated with DNA barcodes. Each oPool contains: (i) ~40 bp of homology upstream of the YFG fragment of interest, (ii) the YFG fragment sequence with a single NNK codon, (iii) BsaI cloning sites, (iv) a DNA barcode composed of codon-position specific regions and six degenerate nucleotides (N), and (v) a conserved i7 primer binding site (PBS_i7) present in all oPools and used for rapid and efficient sequencing library preparation. Current oligonucleotide synthesis technologies allow for a total of nine degenerate positions per fragment: three are used for the degenerate codon (NNK), and six for the barcode. A complete list of all oPool sequences and their detailed composition is provided in S1 Table. 3. Protocol for constructing YFG DMS plasmid library from oPools using two cloning steps that maintain the physical barcode-mutation association. The libraries of oPools are cloned into the plasmid template by Gibson cloning. Following this step, for each fragment, a necessary short-read sequencing using PBS_i5 (included in the 5′ sequencing primer) and PBS_i7 is performed to associate each barcode with its corresponding mutation and to assess both barcode diversity per mutation and mutation coverage for the whole fragment. The ultimate step consists in Golden Gate cloning of the missing 3′ gene fragment between the degenerate fragment and the barcode. An additional short-read sequencing step of the barcodes can be performed to make sure that coverage and diversity have been maintained. Figure created in BioRender.
#DeepMutationalScanning (DMS) experiments are limited by gene size due to library complexity & costs. @christianlandry.bsky.social &co develop an efficient & cost-effective barcoded cloning strategy for plasmid-based DMS libraries that enables study of large genes @plosbiology.org 🧪 plos.io/4abhyUf
Six fishermen who cast a line in the frozen Saguenay River in the Canadian province of Quebec worked for more than two hours to reel in an Atlantic halibut that broke local records. www.nytimes.com/2026/02/07/w...
In #GENETICS, a new model developed by @christianlandry.bsky.social and colleagues examines how molecular dominance determines total protein activity and contributes to phenotypic dominance. buff.ly/CfaTDp7
Ils pourront toujours revenir avec le programme Impact+ :). D’un coté on leur dit de partir, de l’autre on investit pour amener du talent.
Uppsala in late autumn
Join us at the Evolutionary Biology Centre at Uppsala University. We’re searching for an Assistant Professor in Biology. www.uu.se/en/about-uu/...
Best gene synthesis company that does not involve sending $CAD from taxpayers' money south of the border? #synbio
La différence entre le genre de trucs qu'il dit et ce qu'on rapporte dans les médias est frappante. On 'normalise' son comportement en donnant de la structure et du contenu à ce qu'il dit. C'est un phénomène intéressant toute cette banalisation dont il bénéficie. D'autres exemples sont connus?
Another way in which Denmark is helping the US!
Territorial integrity and sovereignty are fundamental principles of international law. They are essential for Europe and for the international community as a whole.
Are we allowed to celebrate anything with all that is happening down the border, to our friends and colleagues, and the fear spreading across the continent?
Victoire!
Let’s go! La Victoire nous visite!
Muller’s ratchet but for an entire society, in real time.
Look like the ones I had recently in Okayama!
Going to the gym is risky!
