Victor Jimenez Zepeda

For all the amazing things yet to come in 2025. Here's to making memories, achieving goals, and becoming the best version of yourself this year! May your heart be full, your mind be clear, and your journey be filled with joy this new year!

Using protein large language models to optimize antibodies to SARS-CoV-2 with >20-fold increase in binding affinity

www.pnas.org/doi/10.1073/... @pnas.org

In landmark, FDA approves first MSC therapy, Mesoblast's Ryoncil for GvHD - The Niche Professor discusses FDA approval of first MSC therapy, Mesoblast's Ryoncil for GvHD, a milestone for the field.

In a first of its kind, the @fda.gov has approved the first mesenchymal stem cell therapy, Mesoblast’s Ryoncil for the treatment of graft versus host disease.

Prevalence of Iron Deficiency and Iron-Deficiency Anemia in US Females Aged 12-21 Years, 2003-2020 This study examines prevalence of iron deficiency among females aged 12 to 21 years to inform future screening strategies for iron deficiency and iron-deficiency anemia.

We found that almost 40% of 12-21 year old females are iron deficient.

jamanetwork.com/journals/jam...

I’ve been asked how this is possible evolutionarily.

I have a few thoughts. 🧵

#ASH24 News: ASH Newborn SCD Screening Program in Sub-Saharan Africa Found Feasible: bit.ly/4faSNXk 🩸🌍

#ConquerSCD #Sicklecell #HemeSky #Hematology

#ASH24 myeloma, Adolfo Alena from Mount Sinai, MDSC with S100A8/9 expression associated with poor Car-t outcome, incubation of CAr-t with S100A8/9 has linear effect on inhibiting cytotoxic effect, can be salvaged with a blocking antibody. Great talk

The horse is out of the barn - financial toxicity is the unrecognized adverse event, and I am so proud of Dr. Greg Knight for his resilience in pioneering work to try to help manage it. @shematologist.bsky.social led an extraordinary Symposium on Quality at #ASH24 @ash-hematology.bsky.social

Abs 287: New model for early mortality in pts with AL amyloid - outperforms older models. #ASH24

Slide on financial toxicity of cancer care

Staggering statistics at #ASH24 #TreatingFairly

Patients with cancer who go bankrupt are nearly 80% more likely to die regardless of disease status.

Our system quite literally kills people.

Induced B-Cell Receptor Diversity Predicts PD-1 Blockade Immunotherapy Response. https://www.biorxiv.org/content/10.1101/2024.12.03.626669v1 Immune checkpoint inhibitors such as anti-PD-1 antibodies (aPD1) can be effective in treating advanc

Induced B-Cell Receptor Diversity Predicts PD-1 Blockade Immunotherapy Response. https://www.biorxiv.org/content/10.1101/2024.12.03.626669v1

The 10 Best Books of 2024 The staff of The New York Times Book Review choose the year’s top fiction and nonfiction.

Here they are — the 10 Best Books of 2024.

Why Everyone Is Drinking Guinness Guinness, the beer of Irish pubs and Irish men, has endeared itself to chug-happy Americans eager to “split the ‘G.’”

Guinness, once synonymous with Irish pubs and older men, is winning over younger, beer-bent Americans eager to “split the ‘G.’”

Topol: AI gearing for 'everything era' Eric Topol, MD, founder and director of the Scripps Research Translational Institute discussed AI’s progress toward the future at RSNA 2024.

As we progress from unimodal to multimodal w/foundation models of A.I., we're moving from the "scan era" to the "everything era" in medicine (with radiology the leading force)
brief summary of my @rsnasky.bsky.social talk #RSNA2024 today
www.auntminnie.com/resources/co...
@auntminnie.bsky.social

title slide of presentation

The @rsnasky.bsky.social meeting is the largest medical meeting in the world. The radiology community is the pacesetter for medical #AI, that we can all learn from. I'm excited to give a presentation during tomorrow morning's plenary session
reg.meeting.rsna.org/flow/rsna/rs... #RSNA2024

Mount Sinai Researchers Identify Six-Gene Pattern to Predict Drug Success in Multiple Myeloma Patients

Excited to share our latest work in #MultipleMyeloma! 🧬 We uncovered a six-gene signature predicting response to venetoclax, but also revealed that 1q gain can drive resistance—and how CDK7 inhibitors might reverse it. #MyelomaResearch

FDA Approves Attruby™ (acoramidis) for the Treatment of ATTR-CM: A New Option for Patients The FDA’s approval of Attruby is significant for patients with ATTR-CM, providing them with another effective treatment option.

🚨🎉 BREAKING NEWS: The @fda.gov has approved BridgeBio's Attruby™ (acoramidis) for the treatment of patients with transthyretin amyloid cardiomyopathy (#ATTR-CM).

Learn more: arci.org/attruby-attr...

Web preview of JAMA Original Investigation "Screening for Helicobacter pylori to Prevent Gastric Cancer."

The addition of H pylori stool antigen testing to fecal immunochemical testing (FIT) screening did not significantly reduce gastric cancer incidence or mortality.

https://ja.ma/3ZjdjjS

2-Year-Old Gorilla Dies After Being Struck by Hydraulic Door at Zoo A Calgary Zoo staff member mistakenly activated a door that struck the western lowland gorilla named Eyare, a report found.

A 2-year-old gorilla died of traumatic injuries last week at the Calgary Zoo in Alberta, Canada, after being struck by a hydraulic door that a staff member mistakenly activated, according to the zoo.

Based on registry data in 3.9M age 65+ who had 4+ prior doses of #COVID19 vaccine, receiving fall 2023 (XBB 1.5) #COVID #booster:

👉Decreased hospitalization by 58%
👉Decreased death by 75%
due to #Covid at 24 wks follow-up.
🔑 Get boosted!
#MedSky #VaccinesWork

bmjmedicine.bmj.com/content/bmjm...

Food for thought! @jamacurrent.bsky.social

Expanding applications of therapies based on GLP1 - Nature Reviews Endocrinology The evidence base in support of the use of medicines based on glucagon-like peptide 1 beyond glucose control and weight loss was substantially bolstered in 2024, as clinical trial data report benefits...

The expansion of GLP-1 drug efficacy evidence in 2024, a concise review by Daniel Drucker, a pioneer of the field nature.com/articles/s41...

A big day of output for the Human Cell Atlas, a global collaborative project with 100 countries to understand our ~37 trillion cells
A Wikipedia of our cells, a "remarkable achievement"
nature.com/articles/d41...
nature.com/immersive/d4...

Halving premature deaths (death between birth and age 70) around the world by 2050 is feasible. The US isn't doing well vs peer countries.
www.thelancet.com/journals/lan...

Orders for Morning-After Pills and Abortion Pills Rise After Trump’s Election Some women are stocking up on the medications, saying they are concerned that the new administration could take steps to restrict access.

Some women across the U.S. are stocking up on emergency contraceptives, abortion pills or both. Interviews with numerous providers of the pills point to a surge in demand in the immediate aftermath of the election.

Figure showing trends in drugs prescribed among people with type 1 diabetes between 2010 and 2023.

GLP-1RA and SGLT2 inhibitor prescribing in individuals with type 1 diabetes increased significantly between 2010 and 2023.

https://ja.ma/4hVWhQk

A new foundation model for nearly all (9!) medical imaging modalities, BiomedParse
www.nature.com/articles/s41...
explainer: www.microsoft.com/en-us/resear...

A mechanism for why durable weight loss is so difficult: epigenetic memory of fat cells
www.nature.com/articles/s41...