Ahmed Balboula

I’m happy to announce that our preprint is out! 🧬🐭

We show that the mouse HSR selfish DNA kills embryos that do not inherit it through a toxin–antidote system, thereby increasing its transmission to the next generation. ⚡

Feedback is welcome!

@takashiakeralab.bsky.social

#SelfishDNA #meiosis4eva

Hybrid female sterility due to cohesin protection errors in mouse oocytes Misregulation of chromosome cohesion during female meiosis serves as a reproductive isolating barrier in mice.

Another announcement! 📣 Our work on hybrid incompatibility in cohesin protection in 🐭oocytes is published!! Congrats Warif El Yakoubi and Eddie Pan!!🎉 We found hybrids with cohesion errors in two distinct genus.
www.science.org/doi/10.1126/...

Congratulations, Takashi, Warif and Eddie, on this excellent work!

Thanks for the highlight, Gabrielle!

Many thanks, Magdalena, it was an honor working with you :)

Truly grateful for the amazing collaboration and team effort with David Glover, Magdalena Zernicka-Goetz @zernickagoetz.bsky.social , Katerina Komrskova, Hans-Dieter Arndt, Amanda Patterson, Dirk Trauner, Michaela Frolikova, Nourhan Ali, Florian Küller, Veselin Nasufovic, Olga Tepla & Jaromir Masata

Spindle-localized F-actin regulates polar MTOC organization and the fidelity of meiotic spindle formation - Nature Communications Errors in oocyte division can cause infertility and birth defects. Here, authors combine a genetic strategy with a novel optochemical tool to show that spindle pole-localized F-actin is essential for ...

Excited to share our latest work led by our talented PhD student @ejsm9.bsky.social We show that Myosins X/VIIb localize F-actin to the spindle&MTOCs in oocytes. With photoswitchable Optojasp, we reveal that spindle/MTOC-localized F-actin drives spindle pole focusing &accurate chromosome segregation

I'm thrilled to share that our story is now out in Science Advances! 🎉 We use quantitative imaging to map the mito central dogma, define translation hubs in the mitochondrial matrix, and show that they're replaced by Mitochondrial Stress Bodies (MSB) when mtRNA processing is perturbed 1/4

I have exhorted others to share positive news even in these uncertain times for US science.

I am really excited that @tamanash.bsky.social’s first paper on the remarkable evolutionary gymnastics of dual-host viruses (even in single codons) is now online.

Follow along here 🧪🧵

Congratulations, Karen, great news!!

Meiosis-specific distal cohesion site decoupled from the kinetochore - Nature Communications In general, the kinetochore position and the sister-chromatid cohesion site are spatially linked. Here, the authors find a meiosis-specific distal cohesion site decoupled from the kinetochore in Perom...

New Akera's lab paper! Congrats @takashiakeralab.bsky.social and Eddie!

the version of record (VoR) of our most recent paper has been published @elife.bsky.social! 🎉🥳 🧪

elifesciences.org/articles/102...

Noninvasive characterization of oocyte deformability in microconstrictions A microfluidic measurement method translates oocyte mechanical characterization into oocyte quality assessment.

Check out our latest paper in Science Advances, in which we built a constriction-based microfluidic device to measure the deformability of oocytes to assess their mechanical properties with minimal impact.
www.science.org/doi/10.1126/...

Aneuploidy of specific chromosomes is beneficial to cells lacking spindle checkpoint protein Bub3 Author summary Accurate chromosome segregation is crucial for the proper development of all living organisms. Errors in chromosome segregation can lead to aneuploidy, characterized by an abnormal numb...

Check out our super cool paper on aneuploidy in cells lacking Bub3. Congratulations to fantastic student Pallavi Gadgil and alum Olivia Ballew. journals.plos.org/plosgenetics...

Congratulations, Marta!