1/4 Thrilled to be sharing new work published today in Nature describing the third wave of results from the PGC Cross-Disorder Group. This reflects a massive group effort to examine shared and unique genetic signal across >1 million cases for 14 psychiatric disorders. www.nature.com/articles/s41...
The Drain of Scientific Publishing arxiv.org/abs/2511.04820
Definitely D. Almost all of middle, south, and Eastern Asia is in there. Even southern Italy!
For the rest of your life, you can only eat food from one of these regions. Which do you choose?
For more maps: brilliantmaps.beehiiv.com/s...
Those three principles are 1. Modeling disorders as polygenic. 2. Including control for population stratification. 3. Awareness of environmental context. Now out on pubmed!
We lay out three consensuses from the field of psychiatric genetics that should be considered before approving genetic tests for psychiatric disorders. The letter was signed by 140 experts in psychiatric genetics and published in Lancet Psychiatry. Now on Pubmed: pmc.ncbi.nlm.nih.gov/articles/PMC...
For those that read their papers on bluesky, those three principles are 1. Modeling disorders as polygenic. 2. Including control for population stratification. 3. Awareness of environmental context.
That’s honestly a breathtaking and needed effort
Then let me tell you about Jean Baudrillard.
You gotta play “smells like teen spirit” if it’s an adolescent psychiatry conference.
I feel this in my bones.
Sample size, discovery power, and effect size of lead SNPs were the strongest determinants of enrichment, as opposed to biological function. I hope it serves as a demonstration of the practical benefit of scientific discovery. I'd like to thank my Coauthors.
Those disorders with larger sample sizes in their GWAS discovery set were significantly enriched for current treatments for those disorders. Those were, schizophrenia, bipolar disorder, MDD, and SUDs. Those disorders with smaller samples were not (yet!) enriched.
Collecting large genome-wide samples may de-risk reinvestment in psychopharmaceuticals. Expanding on past work that lumped all psychiatric disorders together, we conducted a test of the utility of GWAS for specific psychiatric indications. www.nature.com/articles/s43...
Casey Means? Sounds pretty average to me *nudge*.
My mandalorian friend asked me which protein powder I use and I told him “this is the whey”. Happy #MayTheFourth
Let’s say a person from the US wanted to apply and move to Europe. Is there somewhere with step by step advice? Would we need to find a collaborator. Asking for a friend…..
There are articles out there on lesions in deep neural networks in many applications. LLMs can do it in multiple ways, one is attention mapping (as @michelnivard.bsky.social pointed out). Do you know what they used the lesion to test? Was it attention or something else? It would help me find it.
“Er, my question is really in two parts…”
From the new Private Eye, out now.
If you think our academia is unstable, wait until you see our industry!
Getting the message out on how science funding benefits our society @abepalmer.bsky.social in the SD Tribune www.sandiegouniontribune.com/2025/03/09/g...
The BEAR Lab will be opening it's doors in July at the Medical College of Wisconsin, and we are looking for our first Research Tech! This position will help with funded MRI studies looking at the brain and alcohol use. More info: bearlab.science/contact/ #neuroscience #psychology #sciencejobs
Thanks for sharing this thread and your thoughts. I’ve been thinking along the same lines recently.
So where does the AI race end? Space race was the moon. AI..also the moon?
Np. Reddit accounts are good for this kind of thing. I know it’s got a lot of bad too, but people there are much better at this than I am.
I’m not familiar with that plant species, but generally what I would do since I can’t tell if it’s fungal or bacterial.
Yellowing could also be bacterial.
Could be an early fungal infection given the yellowing around the leaves. It doesn’t seem to be a pest. If the leaves are falling off prematurely, I’d look to see if spots with yellowing keep showing up and start to spread. Septoria would be my guess but not sure. Also could be simple singing.
One can only hope.
The Ripke lab has worked on a new stable release of RICOPILI! Updates include compatibility with GRCh38 and imputation using Minimac4. A software tarball and YAML file are provided to help resolve dependency issues:
github.com/Ripkelab/ric...
Any feedback is highly welcome!
@pgcgenetics.bsky.social
