@cnrsbiologie.bsky.social @upcite.bsky.social @ijmonod.bsky.social

🔍 Our hypothesis: the structural integrity of the nuclear pore scaffold, which exhibits a certain elasticity, plays a protective role for the nuclear envelope. This may explain why genetic diseases linked to some nuclear pore components only target specific cell types or organs

Their trick: a 3D template matching approach to push cryo-electron tomography beyond classical subtomogram averages and analyze individual pores complexes.

Have a look at the unexpected architecture of nuclear pores without Nup133: altered symmetries, incomplete ring assemblies and a trend to dismantle giving rise to large openings upon neural differentiation ⬇️

👏 Congratulation to Reiya Taniguchi for the impressive work and to @corniacki.bsky.social who initiated this collaboration.

Nuclear pores safeguard the integrity of the nuclear envelope - Nature Cell Biology Taniguchi et al. structurally analyse nuclear pore complex architecture in situ during differentiation, which is associated with mechanical constraints on the nuclear envelope. They link nuclear pore ...

✍️Our collaborative project with the @becklab.bsky.social (@mpibp.bsky.social) and the Kräusslich lab who applied innovative ultrastructural analyses to analyze nuclear pores in Nup133-/- embryonic stem cells and neural progenitors is now out @naturecomms.bsky.social!
🔗 www.nature.com/articles/s41...