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Shoa Clarke

@shoaclarke

Assistant Professor, Stanford University // Preventive cardiologist for adults & children // https://clarkelab.stanford.edu πŸ§¬πŸ«€πŸ’»

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19.08.2023
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Latest posts by Shoa Clarke @shoaclarke

A tomahawk missile costs the taxpayers the same amount of money as one five-year major NIH research grant. Remember that every time they tell us one of those missed the target, blew up paintings of enemy aircraft or tanks, or was the fifth and unnecessary hit on the same target.

11.03.2026 01:41 πŸ‘ 256 πŸ” 109 πŸ’¬ 4 πŸ“Œ 3
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Trump administration's embattled FDA vaccine chief is leaving again In July, Prasad was briefly forced from his job​, but was reinstated less than two weeks later.

πŸ‘‹

www.cbsnews.com/news/fda-vac...

07.03.2026 16:04 πŸ‘ 2 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0

Sorry I'm not more open-minded about LLMs, it's just some fucking maniacs shoveled out a bunch of useless bloatware featuring that technology, did not give me any chance to opt out, reorganized the entire economy around it, zeroed out gains made by green energy, and made it impossible to buy RAM

05.03.2026 05:17 πŸ‘ 17433 πŸ” 5766 πŸ’¬ 129 πŸ“Œ 101

I love how diligently you have continued to march down this path to solve this problem. Hopefully this will all eventually culminate in a paradigm shift for aortic disease.

(Also, incredible figure)

05.03.2026 06:17 πŸ‘ 1 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
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Estimating Ascending Aortic Diameter From the Electrocardiogram:

In December we published a @jaccjournals.bsky.social Brief Report demonstrating that ascending aortic diameter can be partially estimated from the ECG.

05.03.2026 00:26 πŸ‘ 12 πŸ” 3 πŸ’¬ 1 πŸ“Œ 0

It's so cool that the fbi is basically the make a wish foundation for one podcaster

22.02.2026 18:13 πŸ‘ 7377 πŸ” 1523 πŸ’¬ 5 πŸ“Œ 30
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Opinion | One Man Stole $660 Million. He’ll Never Pay It Back.

www.nytimes.com/2026/02/18/o...

19.02.2026 14:31 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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Opinion | The Olympics Are Not Weird Enough

The Olympics Are Not Weird Enough
www.nytimes.com/2026/02/15/o...

15.02.2026 18:09 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
Surviving as a health equity researcher amidst a shifting political climate - Nature Medicine Nature Medicine - Surviving as a health equity researcher amidst a shifting political climate

A poignant piece from my colleague at the Stanford Prevention Research Center.

www.nature.com/articles/s41...

13.02.2026 21:40 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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A large language model for complex cardiology care - Nature Medicine In a randomized study involving 9 general cardiologists and 107 real-world patient cases, assistance from a specifically tailored large language model resulted in preferable responses on complex case ...

Nice work, @just-jack-1.bsky.social and several other Stanford Cardiology fellows and recent alums! Stanford is a wonderful place for trainees who want to conduct collaborative and high impact research. #CardioSky

www.nature.com/articles/s41...

06.02.2026 20:41 πŸ‘ 2 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
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Genetic Data From Over 20,000 U.S. Children Misused for β€˜Race Science’

Incredibly important story that everyone should read.

These are not disorganized lone actors, but well-funded and powerful networks to be treated as serious threats.

They are using our work to push a eugenicist and racist agenda that is scientifically invalid and morally reprehensible.

24.01.2026 17:05 πŸ‘ 70 πŸ” 43 πŸ’¬ 1 πŸ“Œ 8
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Cardiovascular Statistics in the United States, 2026: JACC Stats

Proud to share the inaugural JACC Cardiovascular Statistics annual report, offering a clear-eyed understanding of cardiovascular health in the United States.

Where we stand. Where we've made gains. And where we're falling behind. #JACCStats #medsky #cardiosky

www.jacc.org/doi/10.1016/...

13.01.2026 21:40 πŸ‘ 3 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
Seth Rosenthal
  9:53 AM
craig hodges for his career shot a three point percentage of 0.39985795454
9:54
which is to say craig hodges might hate round numbers even more than alex
9:54
if he'd hit one more three-pointer in his career he'd be above 40 percent
9:54
and then there would be exactly 50 players in the 40 percent club
alex rubenstein
  10:22 AM
one of these days, probably not in our lifetimes, society will focus on the point of all those anecdotes: to recognize the mere fact that there exists a number that someone reached which means X, Y, and Z, regardless of the level of roundness of that number (ie lets say an nba player had a certain number of career games scoring 30+ points, and that number of games wouldnt be a record, but if you change the threshold to 29 or 31, that unlocks a number of career such games that would be a record, who gives a rip? again, the point of the anecdote should be the acknowledgement that there simply exists a number that someone reached more than anyone or whatever, regardless of whether that number is 100 or 94.618 or 61.849)…or that someone has the most or fewest or 2nd-most or 2nd-fewest, etc. of something without feeling compelled to specifically tie it to a round number (ie if someone hits 71 dingers in mlb next season, it should obviously be framed as the 2nd-most anyone’s ever hit in a season as opposed to 1 of 3 players to hit 70+, which is obviously undermining the feat)

Seth Rosenthal 9:53 AM craig hodges for his career shot a three point percentage of 0.39985795454 9:54 which is to say craig hodges might hate round numbers even more than alex 9:54 if he'd hit one more three-pointer in his career he'd be above 40 percent 9:54 and then there would be exactly 50 players in the 40 percent club alex rubenstein 10:22 AM one of these days, probably not in our lifetimes, society will focus on the point of all those anecdotes: to recognize the mere fact that there exists a number that someone reached which means X, Y, and Z, regardless of the level of roundness of that number (ie lets say an nba player had a certain number of career games scoring 30+ points, and that number of games wouldnt be a record, but if you change the threshold to 29 or 31, that unlocks a number of career such games that would be a record, who gives a rip? again, the point of the anecdote should be the acknowledgement that there simply exists a number that someone reached more than anyone or whatever, regardless of whether that number is 100 or 94.618 or 61.849)…or that someone has the most or fewest or 2nd-most or 2nd-fewest, etc. of something without feeling compelled to specifically tie it to a round number (ie if someone hits 71 dingers in mlb next season, it should obviously be framed as the 2nd-most anyone’s ever hit in a season as opposed to 1 of 3 players to hit 70+, which is obviously undermining the feat)

good morning from the Dorktown slack room

22.12.2025 16:08 πŸ‘ 259 πŸ” 39 πŸ’¬ 9 πŸ“Œ 1
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We’re excited to share our new Nature Genetics paper examining the genetic architecture of aortic valve function and aortic stenosis. We used deep learning of cardiac MRI and MTAG to study disease biology long before clinical diagnosis.

nature.com/articles/s41...

1/10

19.12.2025 19:50 πŸ‘ 21 πŸ” 7 πŸ’¬ 2 πŸ“Œ 1

Congrats @abarad.bsky.social! You are a rising star in precision nutrition! 🌟

13.12.2025 00:07 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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Thrilled to share that I’ve been awarded an AHA Postdoctoral Fellowship! So grateful for the support and honored to have the opportunity to advance my research in precision nutrition for CVD prevention. Huge thanks to my mentor @shoaclarke.bsky.social and collaborators for their guidance! πŸ«€πŸ§¬

12.12.2025 19:00 πŸ‘ 1 πŸ” 1 πŸ’¬ 2 πŸ“Œ 0
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San Francisco woman gives birth in a Waymo self-driving taxi This week, the automated ride-hailing taxis went viral after a San Francisco woman gave birth inside aΒ Waymo taxi while on her way to the hospital.

Got another stamp for my 2025 bingo card
www.sfgate.com/business/art...

11.12.2025 14:37 πŸ‘ 4 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
Tweet by Jay Bhattacharya:

It's the height of irony that the European Commission fined 
@elonmusk
's 
@x
 for not being transparent. The old Twitter handed out blue checks to cronies with no transparency whatsoever. The purpose of the old Twitter blue check system was to suppress dissidents and censor speech.

Quote tweets himself saying: Twitter 1.0 placed me on a blacklist & denied me a blue check on the grounds that I am not noteworthy enough. Meanwhile, Twitter 1.0 gave blue checks to every covid alarmist, whatever their credenitals and lack of notoriety. The EU is silencing political opposition.

Tweet by Jay Bhattacharya: It's the height of irony that the European Commission fined @elonmusk 's @x for not being transparent. The old Twitter handed out blue checks to cronies with no transparency whatsoever. The purpose of the old Twitter blue check system was to suppress dissidents and censor speech. Quote tweets himself saying: Twitter 1.0 placed me on a blacklist & denied me a blue check on the grounds that I am not noteworthy enough. Meanwhile, Twitter 1.0 gave blue checks to every covid alarmist, whatever their credenitals and lack of notoriety. The EU is silencing political opposition.

Imagine you're overseeing the termination of clinical trials, the destruction of people's livelihoods, the dismantling of scientific research in the US, and you're complaining that Twitter didn't give you a blue check 4 years ago.

07.12.2025 15:31 πŸ‘ 752 πŸ” 174 πŸ’¬ 17 πŸ“Œ 20
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NIH funding cuts have affected over 74,000 people enrolled in experiments, a new report says A new report finds over 74,000 people enrolled in experiments have been affected by the National Institutes of Health’s funding cuts.

apnews.com/article/nih-...

17.11.2025 18:55 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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We are excited to announce EchoPrime is published in Nature. EchoPrime is the first echocardiography AI model capable of evaluating a full transthoracic echocardiogram study, identify the most relevant videos, and produce a comprehensive interpretation!

17.11.2025 02:38 πŸ‘ 9 πŸ” 3 πŸ’¬ 1 πŸ“Œ 0
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After two years and thousands of manuscripts, I’ve learned that the real work of an editor isn’t gatekeeping β€” it’s partnership.

My latest JACC Editor’s Page: The Partnership

πŸ”— www.jacc.org/doi/10.1016/...

#MedTwitter #AcademicMedicine #Cardiology

11.11.2025 19:50 πŸ‘ 12 πŸ” 3 πŸ’¬ 1 πŸ“Œ 0
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Specificity, length and luck drive gene rankings in association studies - Nature Genetic association tests prioritize candidate genes based on different criteria.

How do GWAS and rare variant burden tests rank gene signals?

In new work @nature.com with @hakha.bsky.social, @jkpritch.bsky.social, and our wonderful coauthors we find that the key factors are what we call Specificity, Length, and Luck!

🧬πŸ§ͺ🧡

www.nature.com/articles/s41...

07.11.2025 00:05 πŸ‘ 171 πŸ” 74 πŸ’¬ 5 πŸ“Œ 11
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The Editor Got a Letter From β€˜Dr. B.S.’ So Did a Lot of Other Editors.

www.nytimes.com/2025/11/04/s...

05.11.2025 20:34 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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🚨 #AI-based #ECG analysis significantly improved #STEMI detection, reduced false activations, and enhanced recognition of non-conventional presentations. This supports integration of AI-based ECG analysis into acute chest pain pathways. https://bit.ly/4hopPpT

#TCT2025 #JACCINT #CardioSky

28.10.2025 22:00 πŸ‘ 3 πŸ” 3 πŸ’¬ 0 πŸ“Œ 0
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New event at #AHA2025!
GPM Symposium Model Systems: Preclinical to Phase I Bridge
Nov 7 12:30-5:15
Learn state-of-the-art systems to bridge therapies from the Preclinical to Phase I trials
Speakers: Kricket Seidman, Joe Wu, Kiran Musunuru, Vicki Parikh, Eric Adler, and more!

24.10.2025 21:04 πŸ‘ 3 πŸ” 3 πŸ’¬ 1 πŸ“Œ 0
The fragile intelligence of GPT-5 in medicine - Nature Medicine The latest large language model from OpenAI offers safety gains, persistent risks and the illusion of understanding.

🎯
www.nature.com/articles/s41...

17.10.2025 12:56 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

Congrats, Satoshi! Your work is incredible! I feel fortunate to get to collaborate with you. Looking forward to seeing your lab grow!

08.10.2025 03:41 πŸ‘ 1 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
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Excited to share that I’m launching a Computational Genetics Lab spanning MGB Personalized Medicine, Cardiovascular Research Center at MGH, @harvardmed.bsky.social, and @broadinstitute.org. Our research focuses on the genetics of common diseases, with a particular emphasis on cardiovascular disease.

02.10.2025 00:57 πŸ‘ 20 πŸ” 7 πŸ’¬ 4 πŸ“Œ 1

ENDORSE! Please can we make MOC make sense?

06.10.2025 17:25 πŸ‘ 2 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

🀣 Incredible

30.09.2025 15:04 πŸ‘ 2 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0