Cerebellum Science Center

Congrats to our postdoc (Dr. Cheryl Brandenburg) on her new bioRxiv preprint! tinyurl.com/PAGDBS
For the first time, this work shows that the cerebellum gates social vocalizations independently of movement. Targeted PAG DBS can restore communication even when motor deficits remain. #Neuroskyence

2026 Conference - TANGO2 Research Foundation

So proud of our PhD candidate @laurenpeacoe.bsky.social for being invited to speak at the 2026 TANGO2 Family Conference! 🎉 tango2research.org/2026-confere...

Excited to see her share her work on cerebellar circuitry and TANGO2 pathophysiology with families and clinicians. Way to go, Lauren!

Looking forward to this

Cerebellar deep brain stimulation rescues Purkinje cell mitochondrial density in a genetic mouse model of cerebellar ataxia Deep brain stimulation (DBS) improves motor function in a growing list of movement diseases including Parkinson’s disease, dystonia, and tremor. There…

New exciting findings from @miterkomyerslab.bsky.social (former Sillitoe Lab member): Cerebellar #DBS doesn’t just improve behavior—it remodels Purkinje cells, increasing mitochondrial density and preserving MERCs in a mouse model of cerebellar ataxia. tinyurl.com/DBSMERC #neuroskyence #cerebellum

The DMRF has supported dystonia research for 50 years. DMRF-funded research has led to breakthroughs in genetics and therapeutics. The Medical & Scientific Advisory Council is also part of our research network.
https://bit.ly/3Fhc6Sz
#dystonia #dmrf #dystoniafoundation

Aging Brains Show Stripes of Cell Death Purkinje cells, the neurons of the cerebellum, appear to die in an organized pattern, overturning previous beliefs that neurodegeneration occurs homogenously.

Cerebellum aging in stripes?! 🧠🦓
So proud of our student’s (@sarahdonofrio.bsky.social) work showing patterned Purkinje cell loss with age — now featured in The Scientist!
👉 www.the-scientist.com/aging-brains...
#neuroskyence

Congrats to our postdoc Cheryl Brandenburg for being awarded @simonsfoundation.org Fellows-to-Faculty award, which will support her transition into a tenure-track position. Looking forward to her continued work in cerebellar circuits for social communication! Https://tinyurl.com/SFARI2025 #science

Cheryl’s Paper Published in Cell Reports Methods! New Stereo-Tracking Method and Discovery of Axon Bubbles - Poulopoulos Lab Axon bubbles: hidden structures in the developing brain, seen for the first time! A new method we call Stereo-Tracking takes advantage of a bioelectrical interaction between DNA and cells in the embry...

Thrilled to share our new collaborative publication in Cell Reports Methods! Using a stereo-tracking approach, we uncovered “axon bubbles” along Purkinje cell axons during cerebellar development tinyurl.com/axonbubbles
#neuroskyence

NRI, CSC, and Sillitoe Lab came out in full force to cheer on the incredible neurodiverse athletes at the Genuine Cup 2025 final! Big love to @texaschildrens for making it happen 💙⚽🧠 #GenuineCup2025 #Neurodiversity

Coenzyme Q headgroup intermediates can ameliorate a mitochondrial encephalopathy - Nature Decreased brain coenzyme Q10 levels cause encephalopathy and are associated with neurodegeneration; supplementation with 4-HMA or 4-HB restores coenzyme Q10 synthesis in mice and humans with HPDL vari...

Excited to share our latest Nature publication, headed by the Pacold lab. Our experimental compound shows great promise as a novel, mechanistic treatment for a pediatric disorder that can prove fatal. It also highlights the therapeutic relevance of the cerebellum. #neuroskyence tinyurl.com/yh9736m9

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