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Aaron Ragsdale

@apragsdale

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19.09.2023
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Latest posts by Aaron Ragsdale @apragsdale

Thanks Priya!!

21.01.2026 03:22 👍 0 🔁 0 💬 0 📌 0

General moment closure for the neutral two-locus Wright-Fisher dynamics https://www.biorxiv.org/content/10.64898/2026.01.16.700021v1

21.01.2026 02:32 👍 2 🔁 3 💬 0 📌 0

For prob gen on March 25, does anyone know what time the conference starts? I'm considering whether we'll need to book travel the day before, or if day of works with the first session being in the evening.

21.01.2026 02:40 👍 0 🔁 0 💬 1 📌 0
Preview
The Genomic Imprint of Chromosomal Inversions and Demographic History in Island Populations of Deer Mice Abstract. Populations that colonize islands experience novel selective pressures, fluctuations in size, and changes to their connectivity. Owing to their u

Howell et al. used WGS of wild-caught deer mice from two islands and one mainland location in British Columbia to investigate chromosomal inversions and non-equilibrium demographic history of this species.

🔗 doi.org/10.1093/molbev/msaf254

#evobio #molbio #peromyscus

21.11.2025 12:23 👍 9 🔁 5 💬 0 📌 0

In an earlier project simulating quantitative traits/stabilizing selection in a human-Neanderthal model, I became a bit curious about some observed fitness dynamics that I wasn’t expecting.

I’m not sure if this is all that interesting or relevant, but at least it’s short.

21.11.2025 11:09 👍 8 🔁 3 💬 1 📌 0
Early Career Award Seminar The J.F. Crow Institute for the Study of Evolution at the University of Wisconsin-Madison is inviting early-career evolutionary biologists from outside UW-Madison to apply to participate in an early-c...

More info here: evolution.wisc.edu/seminars/ear...

19.11.2025 21:20 👍 1 🔁 1 💬 0 📌 0

Any questions? Would be happy to provide more detail - send me a message or email!

19.11.2025 21:10 👍 1 🔁 0 💬 1 📌 0
Preview
Early Career Scientist Awards 2026 Application to the UW-Madison Evolution Seminar Series - Early Career Scientist Awards.

Wisconsin Evolution is accepting applications for our Seminar Series' Early Career Scientist Award. Come share your evolution research and visit UW-Madison's evolution community. Open to grad students and postdocs (<5 yrs post PhD) from outside UW-Madison.

Apply by Dec 15th here: shorturl.at/4a4O6

19.11.2025 20:55 👍 38 🔁 54 💬 2 📌 1

Elevated mutation near crossovers inhibits the evolution of recombination https://www.biorxiv.org/content/10.1101/2025.11.01.685904v1

02.11.2025 03:32 👍 16 🔁 9 💬 0 📌 0

A model for background selection in non-equilibrium populations https://www.biorxiv.org/content/10.1101/2025.02.19.639084v1

21.02.2025 11:39 👍 14 🔁 9 💬 0 📌 1

The deadline for the Early Career Award applications has been extended to Dec. 7th! There is still time to apply 🧬🐝🐠🍄

If you are a graduate student or a postdoc interested in #evolution, apply today!

03.12.2024 17:03 👍 3 🔁 2 💬 0 📌 0
Early Career Award Seminar The J.F. Crow Institute for the Study of Evolution at the University of Wisconsin-Madison is inviting early-career evolutionary biologists from outside UW-Madison to apply to participate in an early-c...

We are accepting applications for the 2025 Evolution Seminar Series Early Career Award here at UW-Madison. Deadline November 30.

evolution.wisc.edu/seminars/ear...

Please share with grad students and postdocs working in evolutionary biology!

14.11.2024 18:22 👍 2 🔁 2 💬 0 📌 3

Anyone know if archaic hominin sequences (Vindija, Altai Neanderthals, Denisova) have been re-called in reference build 38 and publicly available somewhere?

25.11.2024 18:34 👍 11 🔁 10 💬 0 📌 0
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A path integral approach for allele frequency dynamics under polygenic selection Abstract. Many phenotypic traits have a polygenic genetic basis, making it challenging to learn their genetic architectures and predict individual phenotyp

Our paper on allele frequency transitions under polygenic selection, with a focus on evolve & resequence experiments, is up at Genetics. Led by grad student Nathan Anderson:

urldefense.com/v3/__https:/...

20.11.2024 14:05 👍 7 🔁 4 💬 0 📌 0
Early Career Award Seminar The J.F. Crow Institute for the Study of Evolution at the University of Wisconsin-Madison is inviting early-career evolutionary biologists from outside UW-Madison to apply to participate in an early-c...

We are accepting applications for the 2025 Evolution Seminar Series Early Career Award here at UW-Madison. Deadline November 30.

evolution.wisc.edu/seminars/ear...

Please share with grad students and postdocs working in evolutionary biology!

14.11.2024 18:22 👍 2 🔁 2 💬 0 📌 3

Their paper [which I enjoyed very much] presents some nice pop-gen insights into expected patterns of variation under reciprocal introgression, and raises some interesting Qs about post-admixture selection in humans and Neanderthals.

Read it here: www.cell.com/current-biol...

20.11.2023 19:08 👍 0 🔁 1 💬 0 📌 0
Post image

I wrote a review of the recent paper from Harris, Platt, Tishkoff et al. on early human-to-Neanderthal introgression, out as a Dispatch in Current Biology.

Quick read, free link: authors.elsevier.com/a/1i7L53QW8S...

20.11.2023 19:04 👍 5 🔁 0 💬 1 📌 0

This is a really interesting paper: www.cell.com/current-biol...

Early human introgression into Neanderthals around 250 thousand years ago, resulting in up to 6% human DNA in Neanderthals. And then evidence that human-introgressed alleles were selected against after their introduction.

13.10.2023 22:09 👍 3 🔁 3 💬 0 📌 0

So for K=1, it's trivial ({} and {{1}}). For K=2: {}, {{1}}, {{2}}, {{1, 2}}, and {{1}, {2}, {1, 2}}. I thought I had a nice iterative method worked out, but it starts to blow up around K=5 checking all the duplicated solutions, even though the final number is not that huge.

03.10.2023 00:17 👍 1 🔁 0 💬 0 📌 0

What I thought was an easy algebra problem, that is giving me a headache: I am looking for a way to generate all subsets of the power set for a given K that are closed under union of disjoint sets and complementation of nested sets.

03.10.2023 00:16 👍 2 🔁 0 💬 3 📌 0