Wythe Lab at UVA School of Medicine

We just sent the March edition of our newsletter out to more than 1350 subscribers!

It covers our next webinar (which we are very very excited about), city and county budgets, IMPACT’s Nehemiah Action, opportunities to walk/run/bike/roll through Cville, and more!

mailchi.mp/livablecvill...

Obituary information for Sophia Elaine Burdine Schwartz View Sophia Elaine Burdine Schwartz's obituary, contribute to their memorial, see their funeral service details, and more.

Very sad news: Becky Burdine's 20-year old daughter Sophie passed away suddenly on Tuesday

Becky has been vocal about Sophie, is an @angelmanfoundation.bsky.social advocate, and wants her science/cilia/LR community to know

We love you @rburdine1.bsky.social

www.matherhodge.com/obituaries/S...

GetHIRED! REGISTRATION IS NOW OPEN - Application due Thursday, March 5 Ideal for Postdoctoral Researchers Academic Job Market Insight -Take stock of what you want -Know your options -Prepare outstanding job packet materials -Organize your research & chalk talks -Perfect your interview & avoid the pitfalls Course Features -Six asynchronous online modules -Virtual meetings with an experienced facilitator -Peer feedback, support, & expert advice Course Dates: April 14 – June 23, 2026 Course Fee: SDB Members: $499; Non-Members: $599 Deadline: March 5, 2025 Society for Developmental Biology logo QR Code for GetHIRED! website

#Postdocs! Going on academic job market? Apply for SDB GetHIRED! Take stock of what you want, know your options, prepare an outstanding job packet, organize your research & chalk talks, perfect your interview. Deadline: March 5 sdbonline.org/gethired

NIH FY2025 funding data finally emerges on RePORT The FY2025 funding picture was disrupted significantly by the mandate for Multi-Year Funding of about half of the budget for extramural awards. This produced a mid-year declaration by NCI that thei…

NIH FY2025 funding data finally emerges on RePORT drugmonkey.wordpress.com/2026/03/06/n...

Here is the "effective payline" for each institute, estimated (by Claude) as the percentile where one can expect 80% probability of funding from a logistic regression fit. The effective payline has gone from a historic ~12% to 6% in 2025.

Can a wealthy family change the course of a deadly brain disease? Inspired by the loss of their mother, they have poured millions into studying a key protein behind frontotemporal dementia. But all has not gone according to plan

Fascinating account of trying to find a cure for frontotemporal dementia (FTD): great advances in our understanding of one variant (mutations in GRN resulting in TDP43 proteinopathy) but no success yet with respect to treatment.

www.science.org/content/arti... #medsky

Genetically altered chimeric antigen receptor astrocytes targeting amyloid-β reduce a cardinal pathological feature of Alzheimer’s disease @science.org @washumedicine.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...

Just to see if I still could
Who have I become
Now gene synthesis is…..good?

4 corporate Democrats funded by AIPAC voted with MAGA to let Trump continue to wage illegal war on Iran.😐
•Henry Cuellar: 202-225-1640
•Jared Golden: 202-225-6306
•Greg Landsman:202-225-2216
•Juan Vargas: 202-225-8045

Call & remind them we reject their complicity in fascism

Jeffries should resign.

awesome @navbo.bsky.social webinar today from Dr. Sarah Sheppard at the NIH on lymphatic malformations!

a man in a suit and white shirt is sitting at a desk with a pen in his hand and says oh ! ALT: a man in a suit and white shirt is sitting at a desk with a pen in his hand and says oh !

A nice drizzle across the pie after baking to finish would be super I bet, or if indulgent use a thin layer across the dough as the sauce would probably taste awesome (for the above one I usually only put down olive oil as the sauce).

Bacon, mandolin thin cut potatoes (like for an au gratin), and extra sharp white cheddar is amazing. Just have to cook the bacon and roast the potatoes before putting the pie together and in the oven.

$1B per day and $4B so far of your tax dollars to kill 1000 people in 4 days

And they are just getting warmed up

Let that sink in

New preprint out!
In this study, we introduce NanoFLex, a strategy that combines #HaloTag variants with #nanobodies -based immunolabeling to enable rapid, OneStep-IF #lifetime #multiplexing. Possible due to SmartSecondaries fused to #HaloTag from @nanotag.bsky.social: www.biorxiv.org/content/10.6...

There are two meetings this Wednesday evening you should consider attending.

First, at 6pm at Lane Auditorium the Albemarle County Board of Supervisors will be hear the FY 27 budget proposal, followed by public comment. We encourage you to show up and request more funding for affordable housing.

latest preprint just dropped! From a fantastic collaboration between our lab and Katie Pollard's @gladstoneinst.bsky.social. @ucsanfrancisco.bsky.social graduate student Jodi Lee jodilee539.bsky.social and Gladstone postdoc Jingshing Wu led the project www.biorxiv.org/content/10.6... 1/x

LRSomatic: a highly scalable and robust [Nextflow] pipeline for somatic variant calling in long-read sequencing data www.biorxiv.org/content/10.6... 🧬💻🧪 github.com/intgenomicsl...

NAL is dead

NMB is dead

ARM is dead

What would you think if a hypothetical biology professor at a hypothetical public university in a state starting with an N, who was involved in helping organize a Stand Up for Science Rally this week, and got a visit from their hypothetical Department chair and... 1/2

Promotional graphic announcing “AAV Packaged on Request – AAV9 now available!” with illustrated tubes and Addgene logo.

AAV9 is now available through Addgene's Packaged on Request service. With 4,000+ eligible cargo plasmids available, what would you like packaged in AAV9 for your next experiment?
Learn more: https://twp.ai/4ivYPg

When vessel constriction fails: Cellular mechanics linking developmental remodeling to vascular malformations

Happy to share a write-up of our recent publication @natcomms.nature.com demonstrating
how circumferential actomyosin-driven endothelial cell contractions constrict vessel diameter, providing insights into mechanisms of normal vessel remodelling and CCM.
www.bdr.riken.jp/en/news/rese...

We are happy to announce the JASPAR 2026 tracks for hg38, mm39, danRer11, galGal6, dm6, ce11, ci3, and sacCer3, which represent genome-wide predicted binding sites for transcription factors with binding profiles in the JASPAR CORE collection.

More info: http://bit.ly/JASPAR...

My department at CSU Northridge is hiring a vertebrate functional morphologist! We've got a great EEB group, and we're looking for someone to carry forward a tradition of enriching organismal courses and community-engaged research. App review starts March 15

csucareers.calstate.edu/mob/cw/en-us...

Another reminder as we've crossed into the second half of February. There's still time to apply for the Neurobiology Chair position at Duke University! Just send in a letter of interest and CV by Feb 28. Love of Duke basketball is not required.

Watched her grab the gold last night and was amazed—she’s got like six medals over a career of 20 years!? Amazingly consistent. So happy she finished with a gold.

Very sad news. Gail Martin (1944-2026) was a figure in developmental biology. She pioneered the field of ES cells.
A great colleague, a friend and a lovely person.

Troop 6000

It’s once again Girl Scout cookie season so it’s time for me remind everyone to please consider buying from NYC’s Girl Scout Troop 6000, which is entirely made up of girls living in NYC homeless shelters 🙏❤️

Repeat after me: Filming and documenting ICE activities and arrests is the most American thing you could do. The pinnacle of First Amendment protected action.