Rafael Polidoro

I have to say, I seldom see such a perfectly described immunology of cytotoxic cells as in this article.
And I add, anti-tumor gamma delta T cells are pretty much anti-self NK cells with TCR and do a great job (in my hands) with IL-15 too. So, add that when reading

As the review process goes, take a sneak peak of our exciting manuscript. I'll make a proper thread when it's fully out!

Can I put this on my CV somehow?!??!!

Thanks for inviting me to give a talk. My audience had some good laughs and I hope learned some!
@astmh.bsky.social

If I haven't contacted you by email yet, please consider submitting your manuscript to the Special Issue I'm an editor. We have many great papers confirmed, maybe yours can be too!

www.frontiersin.org/research-top...

flow cytometry bad boy plot

My first year-long mentored student gave me flowers today!
#ProudPI #AcademicChatter #Happy #Science

Thrilled to share my first paper as corresponding author with @rejoicephd.bsky.social, Tryphena Adams, and Anthony Batte! We reanalyzed Non-Human Primate malaria data in light of new insights on AKI/AKD—key findings inside! #MalariaResearch #AKI #openscience

authors.elsevier.com/a/1l3j6_6AGH...

The study section is going from April 24-29. I was gonna be anxious, but it's too long for that

Microbiome-mediated modulation of immune memory to P. yoelii affects the resistance to secondary cerebral malaria challenge Abstract. Malaria is caused by protozoan parasites in the genus Plasmodium. Over time individuals slowly develop clinical immunity to malaria, but this pro

Last week - one paper out - two filled the forms. Got selected for a Rising Stars Cohort. Invited to chair a session at AAI and to give a talk in the Brazilian Immunology Conference.
Not too shabby, 2025.

academic.oup.com/immunohorizo...

Amazing work and amazing pictures. Congratulations 👏

Ten years of bigger samples, better views - MIT McGovern Institute Nearly 150 years ago, scientists began to imagine how information might flow through the brain based on the shapes of neurons they had seen under the microscopes of the time. With today’s imaging tech...

Ten years of bigger samples, better views mcgovern.mit.edu/2025/03/03/t...
Thank you for including our lab's contribution in your remarkable piece about what I believe is the most revolutionary method for studying tiny, fascinating apicomplexans. @benliffner.bsky.social @jvr-lab.bsky.social

Sublethal systemic LPS in mice enables gut-luminal pathogens to bloom through oxygen species-mediated microbiota inhibition Nature Communications - Acute systemic immune activation may affect gut-luminal colonisation dynamics. Here, the authors show that LPS exposure in mice elevates gut-luminal oxygen species levels,...

I am very excited to share our latest publication on the effect of systemic #endotoxin on intestinal #microbiota spearheaded by the brilliant Sanne Kroon at the Hardt lab @eth-dbiol.bsky.social @ethzurich.bsky.social @naturecomms.bsky.social

👉🏼 rdcu.be/eelLn

Adding three peer reviewed accepted manuscripts (one as co-corresponding author) to my NIH application before the study section is such a good feeling!
Not sure it's gonna make a difference, but it made my day.

Huge success!
Today I taught B cell activation class using @taylorswift13 ticket scarcity (FDC) and high demand as an example.
Having a friend (TFh) to switch when you go to the restroom, bring food, is essential to stay days in line. Affinity to Swift is not enough!
#Immunology

a cartoon of homer simpson holding a card ALT: a cartoon of homer simpson holding a card

Bluetorial: The rationale for the “NIH” indirect cost “plan” is based on misunderstood (unintentional or intentional) accounting and math

The value of real government transparency

Quite an increase in influenza A activity. One 4-year-old girl in our village is in dire straights.

GET PEOPLE VACCINATED NOW!

Western blot: Successfully used a 2013 expired gel and a 2021 expired iBlot today. We can leave Brazil, but Brazil doesn't leave us 🤣

All NIH study sections canceled indefinitely. This will halt science and devastate research budgets in universities.

Preparing my materials to enter in tenure-track in Brazil and suffering endlessly with bureaucracy. One thing is clear, my wife will likely not be able to endure such a pain and will go industry here 🤣

Classically, experiments I do on holiday work. Pls, Santa, give me this one too!

Thinking Fast and Slow - Daniel Kanehman in one picture

The type 2 immune response in gut homeostasis and parasite transmission in malaria Malaria predisposes to concomitant bacteremia, resulting in increased mortality risk. Previous studies indicated that malaria causes structural changes in the intestine, induces tolerogenic immune responses, inhibits neutrophil recruitment, suppresses innate synthesis of IFN-γ, dysregulates mast cells (MCs) and basophils, and induces Th2-type immune responses. These can reduce parasite control while increasing enteropathogenic dissemination. Moreover, there is growing evidence that Th2 immunity, while protecting the host from overwhelming inflammation, may also contribute to increased parasite transmission. This review explores the roles of the regulatory immune response in bacterial coinfections and parasite transmission in malaria.

Our brand new review on type 2 immunity in malaria with terrific colleagues Renee Tsolis and Adrian Piliponsky highlighting the roles of mast cells and basophils in orchestrating the host response to infection and parasite transmission to Anopheles mosquitoes.

Please join us Friday 12th at noon EST for Dr. @zamanian.bsky.social seminar at Parasite hour with #PeersInParasitology where he will share his recent work on new targets and strategies for helminth control.
Need a zoom link? Register here: iu.zoom.us/webinar/regi....

A great book title: society in the age of shareholders

As Nietzsche pointed - values (as virtues) will decay and be replaced by things (money) faster and faster

In 2024 I'm thankful for moving up Self-Respect as my top value. It worked wonders, and taught me to say no.

Hard-working wasn't cutting as the top value, it was just burning me faster.

#HappyThanksgiving

Welcome to the family, Juris

Compartmentalized gut lymph node drainage dictates adaptive immune responses - PubMed The intestinal immune system has the challenging task of tolerating foreign nutrients and the commensal microbiome, while excluding or eliminating ingested pathogens. Failure of this balance leads to ...

Super cool!

It reminded me of the beautiful work by @danmucida.bsky.social lab.

pubmed.ncbi.nlm.nih.gov/30988509/

Of the goat. A person complains to a rabbi that their house is too small. The rabbi recommends placing a goat in the living room.
The family gets annoyed to hell with the smell, the poop, the space taken. When they complain the rabbi says - remove the goat.
Now, the house feels like a palace

That if you bite a pencil across the mouth (forcing a smile) will prime you to a good mood at the brain level. And biting hanging, forcing a frown, will prime you to a bad mood.
We have no free will, but we have knowledge and can force a smile to feel it later.

As the Jewish tale +