Sergiu Groppa

Imaging the hidden player: Choroid plexus enlargement in multiple sclerosis The choroid plexus (CP), one key regulator of cerebrospinal fluid (CSF) production and immune surveillance at the blood–CSF barrier, has recently emer…

The hidden player in neurodegeneration and neuroinflammation - excited to share our latest review, newly published in Autoimmunity Reviews!

bit.ly/3ZTlHWV

Therapeutic approaches in adults with myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD): A review of current evidence Recent years have seen a considerable increase in knowledge pertaining to Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease (MOGAD). Nev…

Delighted to share our review on therapeutic paths in myelin oligodendrocyte glycoprotein antibody-associated disease (#MOGAD). Clinically relevant work from our Neurology team at @UdS and amazing collaborators bit.ly/48BLZRg

New perspective on quantifying #neurodegeneration from #MRI

bit.ly/4hFYIXw

Cortical Single-Cell Primers of Abnormal Brain Activity in Parkinson’s Disease | Research Abnormal brain oscillatory activity is a well-established hallmark of bradykinesia and motor impairment in Parkinson’s disease (PD), yet its molecular underpinnings remain unclear. To address this gap...

We link pathological brain activity in PD with distinct signatures in #microglia, #oligodendrocytes and #OPC states and to specific mechanisms of abnormal protein folding, mitochondrial dysfunction and brain immunology in PD for future trials

bit.ly/3IoRFoP

Subcortical i.e stn dbs modulates cortical activity, it reduces pathological oscillation and the cortex can function more physiologically… you need different regions for different functions, therefore good to modulate several regions.. longer story needed!! Hope it gets more clear!!

Frequency- and layer-specific effects of high-frequency STN stimulation on mouse motor cortical areas in vivo Abstract. High-frequency deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an effective evidence-based therapy for Parkinson’s disease; howe

Take a look at our new work, providing explanations for the mechanisms of deep brain stimulation, with insights into the modulation of motor- premotor cortex activity from mouse-based and translatable research methodologies for future therapy solutions
shorturl.at/5Atjh

Structural covariance analysis for neurodegenerative and neuroinflammatory brain disorders Standard MRI focuses on brain structure but may not fully capture disease progression. Mongay-Ochoa et al. review advanced methods for mapping brain connec

Quantifying neurodegeneration is challenging, but a key prerequisite to modify disease courses. In this new review we discuss the opportunieties of structural covariance #imaging for tracking #neurodegenerative disorders.
#Neurology
#MultipleSclerosis
#ParkinsonsDisease

bit.ly/4j7lR4c

Extended coverage of human serum glycosphingolipidome by 4D-RP-LC TIMS-PASEF unravels association with Parkinson’s disease - Nature Communications 4D-TIMS-glycosphingolipidomics expedite clinical serum profiling of 376 GSLs covering ganglio- and neolacto-series, neutrals and sulfatides. Clinical phenotyping of Parkinson’s disease cohort (sub)gro...

#Glycosphingolipidomics alterations iincluding #peripheral #immunity dependant profiles in #Parkinsons disease New Manuscript allert in #NatComm go.nature.com/43AalJZ

#Neurology
#Medicine

Targeting pathological brain activity-related to neuroinflammation through scRNA-seq for new personalized therapies in Parkinson’s disease - Signal Transduction and Targeted Therapy Signal Transduction and Targeted Therapy - Targeting pathological brain activity-related to neuroinflammation through scRNA-seq for new personalized therapies in Parkinson’s disease

Happy to share our new work on cortical sc scRNA profiles in #Parkinsons Disease. We see abnormal #microglia and #oligodendrocytes progenitors,modified mitochondrial function, energy consumption and altered immune activation.Huge basis for new therapeutic pathways development.
go.nature.com/3WgDIwR

Low‐Frequency Deep Brain Stimulation in Non‐Rapid Eye Movement Sleep Modifies Memory Retention in Parkinson's Disease Background and Objective Memory impairment is a frequent and debilitating symptom in neurodegenerative disorders. The objective of this study was to provide proof-of-principle that deep brain stimul...

Enhancing declarative memory in #PD patients by sleep stage specific adaptation of #DBS frequency. A milestone for patients and future neurostimulation algorithms to modulate memory bit.ly/4fu9rCp

Subthalamic control of impulsive actions: insights from deep brain stimulation in Parkinson’s disease Herz et al. review recent studies that have used deep brain stimulation electrodes to record neural activity from, or apply electrical stimulation to, the

Captivating review on control of actions, adaptive, goal-directed behaviours and impulsive traits with an emphasis on the modulatory role of basal ganglia and subthalamic nucleus

academic.oup.com/brain/advanc...

Translational Methods for Parkinson’s Disease and Atypical Parkinsonism Research This volume covers translational paths used to study the pathophysiology of Parkinson’s Disease such as molecular processes and tissue integrity.

Check our new book

link.springer.com/book/10.1007...

Inflammation‐Triggered Enlargement of Choroid Plexus in Subacute COVID‐19 Patients with Neurological Symptoms <em>Annals of Neurology</em> is a leading neurology journal from the American Neurological Association focusing on diseases of the human nervous system.

Check our new research work on choroid plexus alterations in COVID-19

doi.org/10.1002/ana....

Concurrent inflammation-related brain reorganization in multiple sclerosis and depression Neuroinflammation affects brain tissue integrity in multiple sclerosis (MS) and may have a role in major depressive disorder (MDD). Whether advanced m…

Similar morphometric brain alterations in patients with #multiplesclerosis and #depression. Read our latest work

bit.ly/3QZpnCw

Advanced therapies in Parkinson’s disease: an individualized approach to their indication - Journal of Neural Transmission Device aided therapies (DAT) comprising the intrajejunal administration of levodopa/carbidopa intestinal gel (LCIG) and levodopa/carbidopa/entacapone intestinal gel (LECIG), the continuous subcutaneou...

Comprehensive Review on the use of advanced therapies in #Parkinsons disease bit.ly/3UjACrk

Subthalamic stimulation modulates context-dependent effects of beta bursts during fine motor control - Nature Communications How movement speed is neurally modulated remains poorly understood. Here, the authors recorded invasive brain signals in Parkinson’s disease patients during drawing and deep brain stimulation, showing...

Excited to share our new work on motor control in patients with #ParkinsonsDisease-continous and online analysis of brain activity& adaptation of deep brain stimulation in dependancy of the performed movements led to an improved motor control in PD.Important next step for #DBS.
go.nature.com/49vO005

Major heterogeneity of the classical neurological disorders with a strong need of biological definitions and phenotype characterisations: important step for #multiplesclerosis research and future therapies - imaging, immune states & clinics for distinct phenotypes: bit.ly/3U6RT7j

#Tremor is one of the most debilitating symptoms in #Parkinson disease. See our new work, that dissects by the aid of advanced electrophysiology fascinating new insights on tremor generators in #PD and how L-Dopa alleviates tremor. Relevant work for improved future treatments!
bit.ly/43zo3vc

Cerebral vasculitis as a clinical manifestation of neurosarcoidosis: A scoping review The occurrence of cerebral vasculitis in individuals with neurosarcoidosis (NS) is considered to be rare. Although the number of relevant publications…

New review work from us on sarcoidosis related cerebral vasculitis and strokes

bit.ly/3TDxbvf

See our new work on stroke imaging with an advanced deep learning augmented protocol and highly accelerated scanning time
bit.ly/4c78gaE