Benjamín Cartes-Saavedra

We're wrapping up at #bps2026! See you next year at #bps2027 in Philadelphia, February 20-24, 2027!

MICU2 controls mitochondrial calcium signaling and migration in neurons during development Berezhnaya et al. showed that MICU2 is present in the brain during development but is replaced during maturation by MICU3. MICU2 loss during development results in neuronal overmigration in the cortex...

Happy to have contributed to this beautiful work led by @elenaberezhnaya.bsky.social and Dr. Gyorgy Hajnoczky, and thrilled to see it finally out! 👏🏽👏🏽👏🏽

MICU2 controls mitochondrial calcium signaling and migration in neurons during development: Cell Reports www.cell.com/cell-reports...

Disease-causing MFN2 mutants impair mitochondrial fission dynamics by distinct DRP1 dysregulation https://www.biorxiv.org/content/10.1101/2025.04.03.647131v1

Retromer promotes the lysosomal turnover of mtDNA Lysosomal uptake of mtDNA controls mitochondrial quality.

Excited to share our latest paper in Science Advances! We finally dissected a new pathway for mitochondrial quality control upon mtDNA replication stress! Let’s start a short thread! 🧵

www.science.org/doi/10.1126/...

Dependence of mitochondrial calcium signalling and dynamics on the disaggregase, CLPB - Nature Communications CLPB is a protein disaggregase that has been linked to human disease. Here, the authors show that in different models of chronic or acute loss of the mitochondrial disaggregase, mitochondrial Ca2+ han...

Happy to share this research paper in where I had the opportunity to contribute! Click below to read more about the dependence of mitochondrial calcium signaling and mitochondrial fusion dynamics on the IMS dissagregase CLPB

www.nature.com/articles/s41...

Watching axons on the move

Check out this study, ranked ‘Fundamental’, on how the ligand Netrin mediates axon guidance through haptotaxis and chemotaxis.
elifesciences.org/articles/100...

Thanks! I hope you will enjoy it.

As for your question, is because calcium as an ion is not stored for a prolonged time inside the mitochondria, and is either extruded or buffered by species such as phosphates

Quality control of mitochondrial nucleoids Mitochondrial nucleoids, organized complexes that house and protect mitochondrial DNA (mtDNA), are normally confined within the mitochondrial double-membrane system. Under cellular stress conditions, particularly oxidative and inflammatory stress, these…

Quality control of mitochondrial nucleoids

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Our last review from Hajnoczky Lab! It is a comprehensive view about the different roles of mitochondria in global al local calcium signals