Id say yesโฆ.green pipe on the right, mustache face on the left. It matches up pretty perfectly to me
17.10.2025 00:50
๐ 0
๐ 0
๐ฌ 0
๐ 0
Id say yesโฆ.green pipe on the right, mustache face on the left. It matches up pretty perfectly to me
Unbelievable detective workโฆ.
Wanted to get a feel for how many sites are using loading regimens of clofazimine for NTM given PK. If so, what dosing strategy? Any barriers from FDA or manufacturer as far as IND including this dosing strategy? #IDSky
For streptococci, blood cultures virtually always cleared by day 2, so clearing quickly is not helpful. In contrast, for MSSA, MRSA, and E faecalis, clearance of blood cultures after 1 day of therapy was also very helpful at negatively adjusting the risk of IE. #IDSky
@steventong.bsky.social presents the results of the PSSA domain of the SNAP ๐ซฐ trial - the worlds largest trial of staph aureus bacteremia - at #ESCMID2025
fluclox resulted in higher mortality and more AKI compared to penicillin for PSSA
The most important post in #ESCMIDGlobal #ESCMIDGlobal2025 #escmid2025
#IDSky
Say it aint STENO! New #Breakpoints episode out today with the brilliant Amy Mathers and @juliejusto.bsky.social on behalf of @sidpharm.bsky.social
We hope you love it!! ๐ง ๐ถ ๐งซ
podcasts.apple.com/us/podcast/b...
A trojan horse, labeled "use case based on need & suitability" with warriors hidden inside labeled "profit-driven use case". Healthcare execs are greeted at the gates. the castle is labeled "healthcare"
From a talk on clinician job security in the AI era
There may be compelling use cases driven by need & product suitability, but they are a cover for profit-driven uses
Inspired by UPMC Infectious Disease Connect, Telehealth docs who undercut local clinicians for a contract at an urban NC hospital
Noticeably silent amid the upheaval at HHS? Big pharma. Every new drug has NIH somewhere in its DNA--and NIH funding supports the training of their workforce. Now they're finding out FDA isn't safe, either. Wrote about how keeping quiet isn't working My latest @opinion.bloomberg.com (gift link):
#IDSky #MedSky #PharmSky @idsainfo.bsky.social @cidjournal.bsky.social @ofidjournal.bsky.social @sidpharm.bsky.social
๐ฅ Ceftriaxone MIC cutoff of 8 ฮผg/ml is an excellent predictor of ESBL production; PPV and NPV approaching 100% and 99.5%, respectively.
doi.org/10.1128/JCM.00716-14
Scientists have just cured pancreatic cancer in some patients with personalized mRNA vaccines. Pancreatic cancer. And this Trump administration wants to throw it all away.
Theyโre throwing away a cure for cancer.
Blood cultureโnegative endocarditis has been associated with worse outcomes when compared with blood cultureโpositive endocarditis, because pathogenโdirected antimicrobial therapy and other management aspects have been difficult to achieve #idsky
Cefazolin may be an empiric treatment option for complicated urinary tract infections in those institutions with high susceptibilities for common UTI pathogens.
#pharmsky #idsky
rdcu.be/edSSG
In patients presenting with cUTI (including acute pyelonephritis) who are improving clinically on effective therapy, we suggest treating with a shorter course of antimicrobials, using either 5-7 days of a FQ or 7d of Non FQ rather than 10-14d
14 days for cUTI is obselete! #idsky #medsky #EMIMCC
Echinocandin Vs fluconazole step down in patients with candida glabrata candidaemia?!
๐๐ซRetrospective, single-centre cohort study #JAC
No significant difference in treatment duration ,incidence of persistent candidaemia or 30-day clinical failure between 2 gps #idsky
academic.oup.com/jac/advance-...
fear of inadequate empiric coverage leads to excessive use of broad-spectrum antibiotics. to reassure you that it's OK to get it wrong (sometimes), we looked at clinical outcomes when empiric antibiotics were insufficiently broad and needed to be escalated
doi.org/10.1093/cid/...
๐ฅ๐ฅ NEW ๐ฅ๐ฅ
Year In Review: Top Infectious Diseases Articles From 2024
Our new post, a great collaboration with my friend
๐ @idstewardship.bsky.social
1๏ธโฃ6๏ธโฃโก๏ธ๐ RCTs
7๏ธโฃSyst Reviews/Meta
3๏ธโฃ๐Guidelines โจ๏ธWiki_Guidelines
#idsky #EMIMCC #medsky #utisky
EnJoy
Share plz!
www.idstewardship.com/year-review-...
Seems like $ will drive it. If a hospital may already have cefiderocol formulary with broader utility and/or cefta-avi w/ aztreo around itโs a small niche. I like they addressed loading, but regimen throws me in terms of dose vs vial size. Therapeutic need for load in some of those renal strata??
In their defence avibactam is a much better BLI than the 1st gen BLIs.
Lower ratios required for inhibition, less likely to encounter Rx failure through Beta lactamase hyperproduction.
Weโve done an episode on it, link to the show notes here for the interested:
idiots.notion.site/44-Beta-Lact...
And importantly, they gave NO IV LEAD IN to most patients in the oral arm. Started oral on day 1. Further busting the myth that some magical amount of IV lead in is necessary.
In the latest Bench to Bedside Column @sidpharm.bsky.social Dr. Jordan Chiasson and Dr. Kristen Zeitler, discuss IV push administration including safety profiles, PK/PD characteristics, and clinical data for IV push administration prior to utilizing it in specific populations. #Idsky
๐ Scripts/talking points for UTI #diagnosticstewardship #IDSky #MedSky #antimicrobialstewardship #healthcareepidemiology
Not in the clinic setting, but I know of Tobra IM on some occasions for UTI in ED. With the similar PK and PD, same dosing and same concentration, seemingly shouldnโt pose major issues to sub out was how iโve thought about it!
ID rule of thumb is to prophylax against PJP when high-dose steroids are used (i.e. 20mg or more of prednisone daily) for 4 or more weeks. Prophylactic regimens and other indications for prophylaxis are reviewed nicely in the linked JAMA article.
www.doi.org/10.1001/jama...
Interested in the use of antibiotics at end of life? Join our #ESCMID webinar on the topic next Wednesday 9-11am EST!
I'm honored to be speaking among the international panel.
You can register here! #IDSky
docs.google.com/forms/d/e/1F...
๐ฆ New insights from CACTUS: Ceftolozane-tazobactam shows higher clinical success rates than ceftazidime-avibactam for multidrug-resistant Pseudomonas aeruginosa pneumonia. A crucial step in optimizing treatment!
www.thelancet.com/journals/lan... #InfectiousDiseases
๐ References:
1. CLSI M100 ED34:2024, Table 2A-1, Table 2D, Appendix E, Table 2 Dosages
2. Rationale document clsi.org/standards/pr...
#IDSky #MedSky #PharmSky @idsainfo.bsky.social @cidjournal.bsky.social @ofidjournal.bsky.social @sidpharm.bsky.social
๐จ According to this publication beta-lactams with the highest seizure potential include: 1) Cefazolin, 2) Cefepime, and 3) PCN-G (Table 1).
doi.org/10.3390/microorganisms9071505
๐๐ซ Narrative Review @cmicomms.bsky.social
@jeffpears0n.bsky.social
Tetracyclines, the Old and the New
๐นTetracycline 1953
โจDoxycycline 1967
๐นMinocycline 1971
๐นTigecycline 2005
๐นEravacycline 2018
๐นOmadacycline 2018
#IDsky #EMIMCC
www.sciencedirect.com/science/arti...
I wonder if you could start with ampho + vori and request ampho sensi since the isolate looks so ugly. Vori doesnโt seem ideal, but looks to be the best azole option from a pkpd standpoint at that MIC factoring in protein binding and some leeway in dosing with weight-based.