Marina Lavigne

Hot off the press!

I'm thrilled to share that our paper "Unravelling the Maturation Pathway of a Eukaryotic Virus through Cryo-EM" has been published!

Link to the paper: www.pnas.org/doi/10.1073/...

Nature is full of remarkable protein nanomachines, and now we can watch one more in action.

A neuromodulatory circuit-to-molecular pathway for reformatting aversive memories during recall Tan et al. identify a neuromodulatory circuit-to-molecular pathway in rats that updates aversive memories when they are recalled. Noradrenaline from the locus coeruleus triggers synapse-to-nuclear tra...

Excited to share our new paper:
We uncover a locus coeruleus→amygdala circuit linking β-adrenergic signaling to transcription regulation in defined amygdala cells during memory reconsolidation—+ stress or elevated noradrenergic signaling at recall can strengthen memory.
www.cell.com/neuron/abstr...

Steven Spielberg, Denis Villeneuve : I’m free…

My project Degenerative Architecture has been on display on the façade of the Montpellier School of Fine Arts since last week.

New Special Issue out in #AddictionNeuroscience edited by @talialerner.bsky.social on dopamine circuitry and heterogeneity in addiction with articles by @daylab.bsky.social, Tom Hnasko, @mtorregrossa1.bsky.social, and Awatramani Rajeshwar check it out! www.sciencedirect.com/special-issu...

Could targeting viruses be a new hope against neurodegenerative diseases? Current therapies for neurodegenerative diseases largely manage symptoms and only modestly slow progression. This Perspective highlights emerging evidence that vaccines and antivirals may lower…

Despite decades of intensive research, current approaches to treating #NeurodegenerativeDiseases only slow down the seemingly inevitable. Could recent data associating #vaccines with reduced risk of #dementia offer an unexpected beacon of hope?🧪 @sparrerlab.bsky.social

There's a special place in hell for people who benefit daily from state of the art medical treatment and then argue that the means to discover the next state of the art treatment should be eliminated.

An mTurquoise2-Based Glucose Biosensor Glucose is an important substrate for organisms to acquire energy needed for cellular growth. Despite the importance of this metabolite, single-cell information at a fast time-scale about the dynamics...

Great to see this officially out: An mTurquoise2-Based Glucose Biosensor - works in yeast & mammalian cells and is compatible with FLIM: pubs.acs.org/doi/10.1021/...

Tom Morello live in Minneapolis

When two years of academic work vanished with a single click After turning off ChatGPT’s ‘data consent’ option, Marcel Bucher lost the work behind grant applications, teaching materials and publication drafts. Here’s what happened next.

After turning off ChatGPT’s ‘data consent’ option, Marcel Bucher lost the work behind grant applications, teaching materials and publication drafts

go.nature.com/4qLPpcb

Parasites piégés dans le globule rouge, une nouvelle approche antipaludique Face aux quelques 260 millions de cas de paludisme recensés chaque année, l’identification de nouveaux médicaments aux modes d’action innovants est une

#ResultatScientifique🔎| Des parasites du paludisme pris au piège : une approche innovante pour lutter contre la maladie 🦠

✍️ Rachel Cerdan
🤝 @cnrsoccitanieest.bsky.social @inserm.fr @umontpellier.bsky.social
📕 buff.ly/YZ7m9qz

How does your favorite gene respond to stress? Check out our updated “Stressome-app”!

In a new @natcomms.nature.com paper we vastly extend our interactive app with loads of bulk and single-cell transcriptomics after acute and chronic stress. www.nature.com/articles/s41...

I'll walk you through👇

#ResultatScientifique🔎| Un circuit neuronal qui énergise le comportement 🧠

✍️ Emmanuel Procyk et @crewilson.bsky.social
📕 @currentbiology.bsky.social | buff.ly/Dv4XBOt

buff.ly/S7OfpX3

The Alps to lose a record number of glaciers in the next decade How much longer will glaciers survive? A new study from ETH Zurich researchers offers the first detailed projection of how many glaciers could vanish by 2100 due to global warming – and why regions su...

In a groundbreaking study, an international team led by ETH Zurich researchers has for the first time calculated how many glaciers worldwide are likely to remain until the end of the century and for how long. It looks bleak. ethz.ch/en/news-and-...

« Should I stay or should I go » : comment le cerveau apprend en comparant Dans une étude publiée dans Current Biology, des scientifiques montrent que des neurones du noyau paraventriculaire d

« 𝐒𝐡𝐨𝐮𝐥𝐝 𝐈 𝐬𝐭𝐚𝐲 𝐨𝐫 𝐬𝐡𝐨𝐮𝐥𝐝 𝐈 𝐠𝐨 » : 𝐜𝐨𝐦𝐦𝐞𝐧𝐭 𝐥𝐞 𝐜𝐞𝐫𝐯𝐞𝐚𝐮 𝐚𝐩𝐩𝐫𝐞𝐧𝐝 𝐞𝐧 𝐜𝐨𝐦𝐩𝐚𝐫𝐚𝐧𝐭
Des scientifiques de l'IGF montrent que des neurones du noyau paraventriculaire du thalamus permettent aux souris de comparer leurs expériences présentes et passées afin d’évaluer danger et sécurité relatifs.
urlr.me/Zsg2x9

Need help 😬 : anyone knows a good system to stop protein expression in mammalian cells (except degradon, Tet on/off prom, crispr, smash or trip system) ?

« Should I stay or should I go » : comment le cerveau apprend en comparant Dans une étude publiée dans Current Biology, des scientifiques montrent que des neurones du noyau paraventriculaire d

🎉 Félicitations à l’équipe de Stephanie Trouche Institut de Génomique Fonctionnelle - IGF, avec le soutien de l’équipe d’Éric Kremer (IGMM) et la plateforme de vectorologie Biocampus, pour leur publication dans @currentbiology.bsky.social 🧠✨
www.insb.cnrs.fr/fr/cnrsinfo/...

A poster with branding for the MRC-University of Glasgow Centre fo Virus Research, labelled 'Virus Snowflakes.' The poster shows snowflake-like virus designs and song lyrics reading: On the twelfth day of Christmas, a virus gave to me, Twelve fights worth winning, Eleven Christmas dinners, Ten lunar landers, Nine childhood vaccines, Eight tools for teaching, Seven dogs a-barking, Six wasps a-laying, FIIIIVE TIIINY RIIIIIIINGS, Four vaccine platforms, Three genome segments, Two twinned capsids, and A world that is too small to see

Feeling festive?
Why not deck the halls with @cvrinfo.bsky.social's papercraft #VirusSnowflakes and celebrate the science of viruses and the fight against viral diseases.
Download for free: cvr-engagement.co.uk/virus-snowfl...
#scicomm #sciart #decorations

FDA Approves Gene Therapy for Treatment of Spinal Muscular Atrophy FDA Approves Gene Therapy for Treatment of Spinal Muscular Atrophy

FDA approves Itvisma, expanding access to gene therapy for spinal muscular atrophy. The one-time intrathecal treatment is approved for patients two years and older – the first gene replacement therapy available for this broader SMA population. Read more: https://bit.ly/3Kn9mpM

Une piste thérapeutique prometteuse : quand le muscle aide à protéger les neurones moteurs - ARSLA Une équipe de chercheurs de l’Université de Tel Aviv, en collaboration avec des scientifiques français, vient de publier une découverte

👏Pauline Duc et @florage.bsky.social pour leur contribution à cette avancée publiée dans Nature Neuroscience : un microARN musculaire pourrait protéger les neurones moteurs et ouvrir de nouvelles pistes thérapeutiques contre la SLA grâce au financement ARSLA!
www.arsla.org/quand-le-mus...

Cracking the AAV Expression Problem: No Signal? Weak Fluorescence? Here’s Your Step-by-Step Fix from Virus to Detection Learn how to solve AAV expression loss and weak fluorescence with step-by-step optimization of vector design, viral titer, injection dose, timing, detection, and sample processing.

🧬 AAV not expressing?
🔍 Weak fluorescence?
Here’s your step-by-step guide to fixing the most common AAV pitfalls—from titer and serotype to detection and sample processing.
www.ebraincase.com/support/lite...

#AAV #AAVVector #ViralVectors #GeneDelivery #GeneExpression #NeuroscienceResearch

Methodology

My lab is recruiting a post-doc ! please share ! emploi.cnrs.fr/Offres/CDD/U...

Close up photo of the full Moon

I forgot the settings on the last #FullMoon post. Here's a slightly different version though.

#MoonPhotography #MoonPhotos #MoonShots #Photography

Camera settings:
Canon T5i
Sigma 150mm x 600mm
Focal length: 600mm
F-stop: f/10
Exposure time: 1/1600
ISO: 800

Really delighted to share our new article in Current Biology showing that the cingulate-to-dorsolateral prefrontal pathway is not involved in trial-to-trial short-term adaptation but rather in sustained motivational control.
doi.org/10.1016/j.cu...

Tissue-specific consequences of tag fusions on protein expression in transgenic mice Author summary To better understand the function of specific proteins, researchers need ways to quantify their abundance, to visualise their movements, to understand what other molecules they interact...

'In this manuscript, we show that tag fusions often change protein expression to a degree that is highly dependent on cell and tissue context. We characterise two underlying mechanisms, providing information that should help others to design more effective transgenic strategies'

Maladie d’Alzheimer : rétablir les rythmes électriques du cerveau par thérapie génique Les chercheurs souhaitent mettre au point une thérapie génique innovante pour restaurer un bon équilibre électrique dans le cerveau, et ainsi freiner le développement de la maladie d’Alzheimer.

🧠Maladie d'Alzheimer⚡ Rétablir les rythmes électriques du cerveau par thérapie génique. Projet mené au sein de l'équipe dirigée par Eric Kremer et soutenu par @frm-officiel.bsky.social

Lecornu Sébastien succède donc à Sébastien Lecornu.

(censure)

Viral interferon antagonism shapes host tropism Outbreaks of zoonotic viruses in human populations highlight the need to understand the molecular factors that influence viral host tropism and interspecies transmission. A virus’s host range is deter...

Viral interferon antagonism shapes host tropism

journals.plos.org/plospathogen...