Claudia Mimoso

Postdoc positions in Nuclear RNA Biology - Vacancy at Aarhus University Vacancy at Department of Molecular Biology and Genetics - RNA Biology and Innovation, Aarhus University

Postdoc positions available in my lab in Aarhus, Denmark on 'Mammalian Nuclear RNA Production and Turnover Systems'. Please get in touch for further information or simply apply here:
mbg.au.dk/en/news-and-...

Excited to share @suminkim.bsky.social and @mileshuseyin.bsky.social 's new Current Opinion review on how Polycomb complexes mediate 3D genome interactions including mechanistic models and potential roles in gene regulation:
www.sciencedirect.com/science/arti...

Please join Andreas Ladurner and me for the GRC Chromatin Structure and Function conference to be held near Barcelona Spain from May 31-June 5! We accepting abstracts for posters and talks. The meeting is preceded by an awesome GRS. Learn more in our video below and apply www.grc.org/chromatin-st...

🧪🧬New preprint We present cryo-EM structures of reconstituted CTCF–nucleosome complexes, showing CTCF dimerization drives nucleosome oligomerization into defined higher-order assemblies. Disrupting CTCF–CTCF interfaces in mESCs reduces looping and impairs differentiation. tinyurl.com/CTCF-nucleos...

We've got two exciting chromatin talks coming up on Wednesday next week:

@epijenatics.bsky.social from @jbuenrostro.bsky.social's lab and @ambystoma22.bsky.social!

register and join us: us06web.zoom.us/webinar/regi...

🧬📄 Preprint update (v2): We added new biochemical experiments that clarify how IWS1 associates with the transcription elongation complex and further define competition between IWS1 and RECQL5. 🧪⚙️
www.biorxiv.org/content/10.1...

Structural model is already available in the PDB (9MLC).

We’re excited to share our latest preprint on the mechanism of excised linear intron stabilization in yeast! This work was led by PhD student @glennli.bsky.social and was a wonderful collaboration with @maxewilkinson.bsky.social. Link: www.biorxiv.org/content/10.6... (1/4)

I like using my iPad and the app goodnotes! What’s nice is that you can have a paper open twice on goodnotes so you can have the text/figures open side by side. Whatever you write in one window will autosync to the other.

The Vlaming lab continues to grow!
It's an exciting time in the Vlaming lab: we've just had our 2nd PhD student join, and the 3rd is joining in February. Now, we're looking to recruit a postdoc!

International Genome Dynamics course in Institut Curie-Paris (April 8-15), experimental and computational methods in multiomics,with a #TE centered session.
Free registration, until Jan 15th
Don’t miss it!
👉https://training.institut-curie.org/courses/Genome-Dynamics-2026
@institutcurie.bsky.social

RESEARCH PAPER: The exon junction complex coordinates the cotranscriptional inclusion of blocks of neighboring exons
By Bergfort et al., and Karla Neugebauer
➡️ https://genesdev.cshlp.org/content/40/1-2/94.full

Karla Neugebauer Alexandra Bergfort
Yale Center for RNA Science and Medicine

#splicing

We are thrilled to share our latest work uncovering the mechanistic basis of target-directed microRNA degradation (TDMD). This work was driven by @jakobfarnung.bsky.social and @elenaslo.bsky.social in a fantastic collaboration with Brenda Schulman's lab. tinyurl.com/E3TDMD (1/5)

Happy New Year!🎉 We hope everyone has enjoyed the holidays! If you have an exciting chromatin/transcription story, or if you know someone with one, please fill out the form or get in contact with us! 😉
forms.gle/TBi38UgYxPAB...

SF3B1K700E mutation in human embryonic stem cells causes aberrant expression of immune-related genes SF3B1, a component of the U2 snRNP pre-mRNA splicing factor, plays a critical role in splicing and is frequently mutated in cancer, particularly hematologic malignancies. We investigated the effects…

Mahtab Dastpak, @camimoso.bsky.social, @adelmanlab.bsky.social and colleagues report that a SF3B1 mutation in human embryonic stem cells alters splicing and dysregulates immune-related gene expression, providing new insights into the role of SF3B1 in haematologic malignancies.

We are excited to announce a tenure-track or tenured faculty position in Computational Biophysics and Biochemistry, exploring the intricate molecular and cellular processes and the complex interactions of their macromolecular components!

apply.interfolio.com/177120

Undergraduates who are interested in summer research please consider the HHMI Cech Fellows Program. There are many great HHMI labs to choose from including ours!

Registration is open for "The complex life of #RNA" 2026 @embl.org in Heidelberg!

Excellent invited speakers and 30 short talks and even more flash talks selected from the abstracts!

Our lab is seeking a Postdoctoral Fellow. The position is intentionally broad, as we are looking for outstanding researchers from diverse scientific backgrounds to advance our understanding of cilia and ciliopathies: academicpositions.harvard.edu/postings/15526

Proteome-wide in silico screening for human protein-protein interactions Protein-protein interactions (PPIs) drive virtually all biological processes, yet most PPIs have not been identified and even more remain structurally unresolved. We developed a two-step computational...

Thrilled to share that the final piece of my PhD work is now on bioRxiv! biorxiv.org/content/10.1... With support from @nvidia and the @NSF, we used AlphaFold to screen 1.6M+ protein pairs, revealing thousands of potential novel PPIs. All data can be viewed at predictomes.org/hp

KATMAP infers splicing factor activity and regulatory targets from knockdown data - Nature Biotechnology A biophysical model uses knockdown or overexpression data to infer splicing factor activity.

KATMAP infers splicing factor activity and regulatory targets from knockdown data - @daspliceisright.bsky.social go.nature.com/47ycrMJ

Flyer for SYNAPSES Symposium (Thursday October 23rd at Room 116 at 100 College Street) with talks by Ann Rose Bright, PhD at 9:00am, Peter Hasenhuetl, PhD at 10:00am, Minhyeok Chang, PhD at 11:15am, and Zhenggang Zhu, PhD at 12:15pm. Registration QR code at top right.

"TOMORROW @yaleneuro.bsky.social @kavliatyale.bsky.social Yale present #SYNAPSES, our senior postdoc symposium! 🙌

Hear from four incredible researchers 👩‍🔬🥼 as they share their latest discoveries and insights! 🗣️

You won't want to miss it! 🗓️"

mRNA poly(A)-tail length is a battleground for coronavirus–host competition Most eukaryotic mRNAs contain a poly(A) tail, which in post-embryonic cells enhances their stability. Many cytoplasmic RNA viruses also harbor poly(A) tails on their genomic RNA and mRNAs. Here, we re...

Check out the latest work from our lab, led by Arash Latifkar @ara-latifkar.bsky.social , www.biorxiv.org/content/10.1...

mRNA initiation and termination are spatially coordinated Transcriptional initiation and termination decisions drive messenger RNA (mRNA) isoform diversity but the relationship between them remains poorly understood. By systematically profiling joint usage o...

Thrilled to share our work on transcription initiation and termination being spatially coordinated out today in Science! www.science.org/doi/10.1126/...

If you’re interested in exploring the relationship between chromatin organization and epigenetic memory using chromatin tracing microscopy, my group is recruiting a talented PhD student 🥳

Giant DNA viruses encode a hallmark translation initiation complex of eukaryotic life In contrast to living organisms, viruses were long thought to lack protein synthesis machinery and instead depend on host factors to translate viral transcripts. Here, we discover that giant DNA virus...

Historically, viruses were thought to primarily use host cell's translational machinery. New work from @harvardcellbio.bsky.social faculty Amy Lee reveals that a giant DNA virus encodes its own IF4F initiation complex, suggesting an unexpected evolutionary innovation. www.biorxiv.org/content/10.1...

Cell-type-specific dysregulation of gene expression due to Chd8 haploinsufficiency during mouse cortical development Yim et al. use single-cell transcriptomics to elucidate the molecular outcomes of Chd8 haploinsufficiency in the mouse cortex. Their results provide insight into dynamic, cell-type-biased transcriptio...

Out in Cell Genomics: A comprehensive analysis of the cell-type-specific effects of CHD8 loss of function on gene expression in the embryonic and juvenile mouse cortex. Thread 🧵:
www.cell.com/cell-genomic...

Molecular basis of polyadenylated RNA fate determination in the nucleus Eukaryotic genomes generate a plethora of polyadenylated (pA+) RNAs[1][1],[2][2], that are packaged into ribonucleoprotein particles (RNPs). To ensure faithful gene expression, functional pA+ RNPs, in...

How are RNAs sorted for export vs. degradation in the nucleus? In collaboration with @heick.bsky.social’s lab we (@clemensplaschka.bsky.social and @juliusbrennecke.bsky.social labs) discovered a direct mechanistic link between the export and decay machineries: www.biorxiv.org/content/10.1... (1/x)

📣 Our department is hiring an Assistant Professor in Evolutionary Cell and Molecular Biology to join the @weillinstitute.bsky.social PLS spread the word!
academicjobsonline.org/ajo/jobs/30607

Registration and abstract submission is open for the 10th annual Danish RNA Society meeting 🇩🇰 - this year in Aarhus!
Deadline is October 1st
danish-rna-society.nemtilmeld.dk/8/

Congrats Hanneke!! 🥳🥳