Our 3D Denoising Deep Learning Algorithm, CryoSamba, is now available to all SBGrid users freely. Instructions on how to use are provided on the official SBGrid page - sbgrid.org/software/tit...
Please source the programs tree every time you want to use CryoSamba!

Link to Paper - t.co/LnPYiXrLEG

Happy holidays with Holey Endosomes. We share our work using 3D EM demonstrating that tiny perforations in endosomes in neurons allow access of cyrtosolic alpha-synuclein to endocytosed alpha-synuclein pre-formed fibrils, thereby triggering toxic alpha-synuclein aggregation.

CryoSamba: Self-supervised deep volumetric denoising for cryo-electron tomography data Cryogenic electron tomography (cryo-ET) has rapidly advanced as a high-resolution imaging tool for visualizing subcellular structures in 3D with molec…

Link to paper:
www.sciencedirect.com/science/arti...

GitHub - kirchhausenlab/Cryosamba Contribute to kirchhausenlab/Cryosamba development by creating an account on GitHub.

Code and data is freely available now!
github.com/kirchhausenl...

Merry Christmas and our best wishes for a peaceful 2025. Say goodbye to the noise with CryoSamba, our self-supervised deep denoising algorithm for CryoET now published in JSB.

Official account of the Kirchhausen Lab @harvardmed.bsky.social , @harvardcellbio.bsky.social
and @bostonchildrens.bsky.social. We'll be tweeting about papers, projects, events and seminars. Follow us!