Transformer-based AI has boosted
@nanoporetech.com
sequencing accuracy, but at a cost to portability due to GPU demands.
Our new work, spearheaded by
Sara Bakic, introduces Campolina link.springer.com/article/10.1... to improve nanopore signal segmentation for event-based mappers.
A line graph showing the success rates for fiscal years 2015-2025 as a function of percentile score. The curve for fiscal year 2025 is substantially lower than for previous fiscal years.
With these results in hand, we can now reproduce the graph that @joshuasweitz.bsky.social posted.
It is still shocking, but we can now understand why it looks the way it does: The number of R01 and R56 awards were down while the number of applications were up.
16/20
The plot is only part of the story.
The data do not include lost science via terminations, freezes, stalled payments, and award delays. The collapse in awards rates will lead to job loss, gaps in research programs, and drive scientists to spend more time writing grants rather than doing science.
Graph of award probability of R35 and R01 from NIH factbook as a function of review rank percentile. As is apparent, 2025 is a significant departure, with lower award probabilities at all scores <40 and significant departures from norm, where even being in the top 10% is no longer a nearly certain indicator of success. Data source: https://report.nih.gov/nihdatabook/report/302
The data is in: the NIH goalposts have shifted.
What were once almost certain fundable scores have become coin flips and what used to be likely grants have become aspirational, leading to fewer awards.
Another manifestation of how HHS policies have led to fewer awards and less science.
oh yeah?
There are a lot of options, but I’ll never *not* cue up Livin’ on a Prayer at the 50% mark, because I need all the cheesy confidence I can summon up for the second half.
Yes! High stakes synchronized ski teams?! In searching around apparently any time a sighted person tries it (with a blindfold), no matter how skilled a skier they are the universal response is that it’s psychologically terrifying.
Was just saying this last night watching downhill. Where’s mu commentary on who the athletes are, their training regimen, how they got to where they are today and how the rules of the event work? Why am I stuck searching Wikipedia for literally the basics?
Sled hockey is better in this respect.
you’re hired
a pack of kittens closes in a a large dog standing on a chair
David Attenborough [whispering]:
“As the predators close in on their helpless prey, we can only watch in silent horror, for it is not man’s role to interfere in the hierarchy of nature.”
👇
Just a reminder - Please Register for the 3rd Codon Usage Conference in Montreal, Canada from May 31- June 3, right after the RNA Society Meeting.
Even if you can't go, please share! #RNA #RNAsky #RNAbiology
sites.google.com/view/codonus...
Alternative periodic system of chemical elements (source: Wikimedia)
This periodic table shows the origins(!) of chemical elements: The carbon in your bones was created under extreme conditions within dying stars. The iron in your blood comes from exploding stars & the gold in your teeth from neutron stars. We are literally made of star stuff. #science #sagan #stars
Scientists: for a new story, I have one big question—>
What is a “good day” in the lab?
I’m looking for epic examples of the best day ever to general criteria for what constitutes a “good day” compared to a nothing-burger day.
Ping me if you have examples to share!
Re-posts appreciated!
The best days is when I get a fresh batch of data, I start exploring and analyzing it, and I realize there really is something interesting going on and I'm the only person in the world who knows about it for a little while
So strange how none of these FAQs are "how many experience points do I need to stop taking this quiz every year"
FAQ 8: Can I lose XP? Generally, XP remains with you once earned. However, if your admin decides to reset or clear the slate, then you'll lose all the XP earned.
Absolutely no user has ever asked this question upon learning about this system. None.
A screenshot of FAQs for XP Answer to some common questions about XP. 1. What are Experience Points (XP)? Experience Points (XP) are rewards you earn by completing learning activities on the platform. They reflect your progress, track engagement, and help you unlock new learning levels. 2. How can I earn XP? You earn XP by completing a variety of learning learning activities, such as courses, videos, audio books, journeys, skill benchmarks, updating role, focus skills, and more... 3. How do I move from one level to another? Each level has a defined XP requirement. As you accumulate XP, you automatically advance to the next level once you meet the threshold... 4. How can I stay on top of the XP leaderboard? To rise on the leaderboard, consistently complete learning activities and particpate in ongoing programs or challenges... 5. What's the benefit of earning XP? XP helps measure your learning momentum and recognize your effort. It also contributes to attaining achievements, maintaining certifications, and discovering new learning opportunities within the platform.
"we've added this new feature to the online training system, so let's answer some frequently asked questions about whether there's any point to it at all. sneak preview: no"
it's a level tree for the university's online learning system. it is a series of icons and XP points, with zero additional details or branches. it does not go to 11.
cannot wait until I get to level 4 and unlock the... blue triangle over the white oval
Also I really should be unlocking some new skills in my tech tree considering how many times I've passed the radiation safety quiz.
A screenshot of the university of colorado "information security awareness" required course. The top right has an orange badge reading "EARN 60 XP"
Well this is new.
Now I want to know how many times to I have to take the university's IT security awareness quiz before I level up.
Why do I have to pretend that I'm going to print something in order to save it as a PDF. Why do I have to engage in a little ruse.
you can tuck him in a bucket in the corner there
either round or square
Increasingly the stories sound like the stories about tourists picked up in Iran or Russia, for trivial or inexplicable reasons. How long before we start to read them and say, like Russia and Iran, "well, they really should have understood the risks of visiting the United States."
Dogs and a handler from the Nome serum run
I’ll pack the sled
This is so cool someone should do kindergarten teachers next
Heard someone say 'hemogoblin' yesterday, and I think I will be keeping the word for a long time, potentially forever.
Sporophytes, on a farm wall, catching the late evening light.
County Clare, Ireland.
Cormacscoast.com walking tours
How consistent are your input lengths? When we do protocol optimization for direct RNA seq, especially short read heavy stuff, we run everything on a Tapestation prior to nanopore adapter ligation so that we can think in moles and not nanograms.
Movie description of the B horror move Death PhD. Gawdawful movie.
Now this is a movie plot!!! Someone understands grad school.
