Chandra Saravanan

Congratulations!

Everyone please read and act! 👇

Glycocalyx dysregulation impairs blood–brain barrier in ageing and disease - Nature Disruption of mucin-domain glycoprotein expression and function in the endothelial glycocalyx are associated with ageing and Alzheimer’s disease, leading to dysregulated blood–brain barrier function.

Happy to share this new #glycotime work with collaborator Tony Wyss-Coray, led by grad student Sophia Shi, mucin loss at the BBB is associated with aging and cognitive decline, can be reversed by restoration with with gene therapy. Aging is a mucinopathy!

www.nature.com/articles/s41...

Say what now?!

A quick guide to protein glycosylation: 7 most importants questions about glycosylation answered in one short review
bit.ly/3Xis7xP

#glycotime

Why Trump’s Data Purge is a Digital Book Burning How reporters tracked the Trump administration's data purges in real time.

slate.com/podcasts/wha...

I want you to imagine that your baby has been born with mysterious symptoms. A hospital data scientist is trying to figure it out with rare disease data from the CDC. But suddenly that information is deleted. Today’s show. With @jasonkoebler.bsky.social:

Graphic showing modification of mRNA with ADP-ribose mediated by bacterial enzyme cmdTAC

Check it out! Another novel RNA modification - ADP-ribosylation - that was previously only known on proteins. A cousin to #glycoRNA 👏

www.nature.com/articles/s41...

Hyperacute rejection-engineered oncolytic virus for interventional clinical trial in refractory cancer patients Recently, oncolytic virus (OV) therapy has shown great promise in treating malignancies. However, intravenous safety and inherent lack of immunity are…

Oncolytic virus (OV) therapy: recombinant Newcastle disease virus with porcine α1,3 galactosyltransferase (α1,3GT) gene triggers hyperacute rejection. Clinical trial showed a high rate (90.00%) of disease control and durable response.
tinyurl.com/3fx7aur8

#glycotime

1/
Hi 🦋! Did you know? Glycans—complex sugar structures—decorate almost every protein processed by the ER/Golgi. These N-glycans coat our cells, playing critical roles in cell interactions and immune processes. 🍬 Curious about how they vary? Let’s dive in! #GlycoTime

Single Cell & Spatial Transcriptomics Analysis Cold Spring Harbor Laboratory Meetings & Courses -- a private, non-profit institution with research programs in cancer, neuroscience, plant biology, genomics, bioinformatics.

meetings.cshl.edu/courses.aspx...

I'm excited to rebuild this #science community over here on Bluesky! In honor of this clean slate, here's a repost of my favorite #epithelial cell building its brush border. @tyskalabactual.bsky.social