Colm Healy

Antidepressant treatment and risk of subsequent bipolar disorder in adolescents with unipolar depression Background Selective serotonin reuptake inhibitors (SSRIs) are a common treatment for depression and anxiety in adolescents but are associated with an increased incidence of bipolar disorder (BD). Whe...

Is the link btwn Adolescent SSRI use & Bipolar Disorder causal?

Our study suggests: 𝐍𝐨.

When accounting for unmeasured confounding (e.g., depression severity) via Instrumental Variable analysis, the evidence for a causal link disappears.

mentalhealth.bmj.com/content/28/1...

#Psychiatry #MedSky

What % of all kids in the UK come to child and adolescent mental health services (CAMHS) at some stage in childhood (0 - 18)?

15 years ago, it was 1 in 17 children.

Now it’s a pretty staggering 1 in 5

www.cambridge.org/core/journal...

Prevalence of Psychotic Experiences in Children and Adolescents Presenting to Mental Health Services: A Systematic Review and Meta-analysis AbstractBackground. There has been a wealth of research on psychotic experiences (PEs) in children and adolescents, highlighting their prevalence and clini

What is the prevalence of psychotic experiences in child & adolescent psychiatry services?
All studies - 54%
With associated distress - 45%
Interview only - 36%
At least a 1/3 reporting this pluripotent marker. Important info for clinicians. @edinburghcapsych.bsky.social
doi.org/10.1093/schb...

Common acne medication could reduce schizophrenia risk - ABC listen A drug used to treat acne and to prevent malaria, doxycycline, could reduce the risk adolescents developing schizophrenia. The association was seen in a study looking at more than 50,000 adolescents ...

@iankellehermd.bsky.social chatting with Dr Norman Swan from ABCs the heath report about the Doxycycline and reduced risk of schizophrenia (doi: doi.org/10.1176/appi... ), worth a listen. 🎧👂: www.abc.net.au/listen/progr...

Edit 2: Massive congrats to the first author (who I couldn't find on blue sky) @drullalang.bsky.social 👏👏👏

Edit: so excited I misspelt "trial", apologies. 😅

Could a common antibiotic help to prevent schizophrenia? New study findings YouTube video by Ian Kelleher Lab

Notes
1) active control comparison
2) gformula to simulate the effect for everyone under all treatment conditions.
3) negative control exposed and negative control outcome analysis.
Podcast link for those who prefer to listen. ⬇️⬇️⬇️
m.youtube.com/watch?v=G3Hi...

Doxycycline Use in Adolescent Psychiatric Patients and Risk of Schizophrenia: An Emulated Target Trial | American Journal of Psychiatry Objective: As many as half of individuals who develop psychosis had attended child and adolescent psychiatric services at some stage in childhood, highlighting substantial opportunities for prevention...

New research using an emulated target trail approach with all adolescent CAMHs users in Finland suggesting that Doxycycline (an antibiotic) can reduces future risk of schizophrenia.
Massive congrats to @iankellehermd.bsky.social @edinburghcapsych.bsky.social
doi.org/10.1176/appi...
More info ⬇️⬇️⬇️

The Mirror Stage | Dublin & Cork | Nov 7 - 12 & 18 - Brokentalkers Brokentalkers present The Mirror Stage a powerful new theatre work created with and inspired by people who have lived through Psychosis.

PPI representatives from the RCSI PSI-STAR study have collaborated with Brokentalkers on 'The Mirror Stage' - a performance inspired by the lived experience of psychosis.

It premieres at Project Arts Centre, Dublin (5–12 Nov) and The Everyman, Cork (18 Nov).

⬇️ brokentalkers.ie/whats-on/the...

Thanks Niamh. ☺️

I wrote a blog back in May about 30-year trends in self-reported psychological distress.

Have things changed? From the 1990s to the early 00s-- not so much. But from the 2010s onwards-- possibly, and most evidently for young people.

Our new research on whether SSRIs curb the risk of later psychosis. We used quasi-experimental methods with the entire Finnish national birth cohort and, sadly, we find no evidence for a protective effect.
Secondary prevention needs to be more radical in it's thinking about SMI prevention.

Out today in BJPsych: 45% of people with a psychotic or bipolar disorder attended CAMHS in Wales at some point in childhood/adolescence🧒

This replicates similar findings from Finland by @iankellehermd.bsky.social & co - showing this applies to UK CAMHS as well. doi.org/10.1192/bjp....

@iankellehermd.bsky.social and co previously demonstrated that ~50% of those with psychosis and bipolar disorder had been to CAMHs in Finland.
That was no fluke, as they have now demonstrated that it's 45% in wales. Great work by @kirstieohare.bsky.social 👏 👏
Paper: doi.org/10.1192/bjp....

Shared characteristics associated with both psychotic experiences and likelihood of being treated with stimulant medications may instead be driving the relationship.

Concerns have been raised that stimulant medications could increase risk of psychotic experiences in young people. Our new research shows no evidence for such a causal relationship 💊🧠

Paper 👇
publications.aap.org/pediatrics/a...

Very nice work by @valentinakieseppa.bsky.social on whether psychotic symptoms predict future risk of psychosis in CAMHs inpatient users. ⬇️⬇️

Adolescents hospitalised for non-psychotic disorders have a high risk of psychosis in adulthood. But do (attenuated) psychotic symptoms predict later psychotic illness? The answer isn’t necessarily what you might expect…

Open access in #PsychologicalMedicine

New research shows >50% of specialist adult mental health service use comes from former #CAMHS patients

We need early intervention in childhood to change these poor long-term outcomes

That's why we need much more research on mental illness prevention in #CAMHS

👉 www.cambridge.org/core/journal...

Adult psychiatric outcomes for young people who attend Child and Adolescent Mental Health Services YouTube video by Ian Kelleher Lab

See our full video abstract on Adult Psychiatric Outcomes of Young People Who Attend Child and Adolescent Mental Health Services here: www.youtube.com/watch?v=vlIo...

@c-healy.bsky.social @drullalang.bsky.social @kirstieohare.bsky.social @hughramsay.bsky.social @elainelockhart.bsky.social