Emilia Favuzzi

Very interesting work from the amazing historian who I happened to have married

Always nice to wake up to "Yale Today" including the head of your research group! Today's article about the collaborative work going on at @wutsaiyale.bsky.social with @emiliafavuzzi.bsky.social and others: news.yale.edu/2025/12/05/w...)

It’s not the thought that counts: Allostasis at the core of brain function The authors review evidence that the primary function of the brain, supported by distributed neural systems, is the predictive regulation of physiology (i.e., allostasis). An example from Alzheimer’s ...

It’s not the thought that counts: Allostasis at the core of brain function
www.cell.com/neuron/fullt...
#neuroscience

Genetics of human handedness: microtubules and beyond Handedness (i.e., the preference to use either the left or the right hand for fine motor tasks) is a widely investigated trait. Handedness heritability is consistently estimated to be 25%. After decad...

Great review on The Genetics of Human Handedness: Microtubules and Beyond www.cell.com/trends/genet... - handedness is such an interesting phenotype!

WTI Postdoctoral Fellowship applications are open! Unique opportunity for those pivoting fields or working across disciplines. I’d be happy to support candidates with a background in immunology and/or in vivo 2-photon imaging, including collaborations with other WTI labs wti.yale.edu/initiatives/...

WTI Postdoctoral Fellowship applications are open! Unique opportunity for those pivoting fields or working across disciplines. I’d be happy to support candidates with a background in immunology and/or in vivo 2-photon imaging, including collaborations with other WTI labs wti.yale.edu/initiatives/...

Eerie how timeless this quote is. Came across it while walking in downtown San Diego.

Every few months the "good lab hands" thing comes up and it misses a key point: you can learn to have good hands. Training matters.

Good hands aren't some magic gift from the PCR gods, you have to develop them through directed repetitive practice, like any other skill

Picture of symposium room with podium. Two projector screens on the sides of the podium say "Kenneth Rainin Foundation 2025 Innovations Symposium" with a picture of Turtle Bay Oahu, Hawaii.

Picture of Zachary Gursky, smiling, holding a name tag that says "Kenneth Rainin Foundation 2025 Innovations Symposium, Zachary Gursky, Yale University, Grantee"

Excited to be representing the @emiliafavuzzi.bsky.social lab at @krfoundation.org 's 2025 Innovations symposium! If you're here, feel free to say hi and come talk about brain-immune system interactions! #idb #brain #neuroscience #immunology #research #scicomm

A postnatal molecular switch drives activity-dependent maturation of parvalbumin interneurons Neuronal activity triggers PGC-1α-mediated transcriptional programs that drive the late maturation of PV+ interneurons, essential for cortical circuit function. PGC-1α partners with ERRγ and Mef2c to ...

1/10 Our latest research, led by Monika Moissidis, identifies a mechanism regulating the maturation of PV interneurons in the #cortex. This is the story @cellcellpress.bsky.social www.cell.com/cell/fulltex... ⬇︎ thread @devneuro.bsky.social @kingsioppn.bsky.social
@wellcometrust.bsky.social

Call for 20 Assistant Professor positions Karolinska Institutet is a world-leading medical university with a long and proud history of ground-breaking research. We are now recruiting outstanding early-career researchers with particularly exce...

Karolinska is looking for 20 (!!) assistant professors and offering 6 year appointments with ~1M USD startup packages.

ki.se/en/about-ki/...

Equity in science isn't optional, it's essential! Explore @cellpress.bsky.social Inclusivity in Science collection, featuring research and perspectives that push for a more diverse and inclusive scientific community 🔬🔎🌍https://www.cell.com/cp/collections-inclusivity

Sleep need–dependent plasticity of a thalamic circuit promotes homeostatic recovery sleep Prolonged wakefulness leads to persistent, deep recovery sleep (RS). However, the neuronal circuits that mediate this process remain elusive. From a circuit screen in mice, we identified a group of th...

New collaborative study out with Mark Wu’s group identifies a thalamic reuniens-zona incerta circuit as both responsive to induced sleep deprivation and essential for mediating recovery sleep. Further perspective on this work follows./1
www.science.org/doi/epdf/10....

📌

Something I've been feeling a lot lately, but haven't heard much about is the grief that comes with being an early career scientist in America in 2025.

I think we all understand that, even if things turn out well, there is no going "back to normal" now.

A (sad) thread /1

GABA-dependent microglial elimination of inhibitory synapses underlies neuronal hyperexcitability in epilepsy - Nature Neuroscience The microglia–neuron interactions contributing to neuronal hyperexcitability are unclear. Here, the authors show how GABA and C3 signaling coordinate microglial engulfment of inhibitory synapses, driv...

Exciting to see growing work on microglial GABA receptors and their role in regulating inhibition. Here, hyperactive inhibitory neurons in epilepsy activate microglia via GABA. Activated microglia then eliminate inhibitory synapses through a GABA–C3 feedback loop. www.nature.com/articles/s41...

I am looking for a postdoc with an immunology background interested in joining a Yale neuroscience lab to study how the brain controls immunity. At Yale, we have a wonderful interdisciplinary & collaborative #neuroimmune community. Please reach out or share with anyone who might be interested!

An AAV capsid proposed as microglia-targeting directs genetic expression in forebrain excitatory neurons Cao et al. demonstrate excitatory neuronal tropism of the AAV capsid AAV-MG1.2 that was initially proposed for targeting microglia in the mouse brain. AAV-MG1.2 shows great promise for expanding our g...

"An AAV capsid proposed as microglia-targeting directs genetic expression in forebrain excitatory neurons"
www.cell.com/cell-reports...

Xiangmin Xu & colleagues
@cp-cellrepmethods.bsky.social

Trump administration revokes Harvard's ability to enroll international students International students make up more than a quarter of Harvard University's student body. Harvard says the government's actions, which could cut off a major revenue stream, are "unlawful."

International students upend their lives to join American science, bringing their novel insights that drive innovation.

Now, they are being illegally targeted by Trump, because Harvard won't back down.

Classic bully behavior.

We Stand Up for International Students.

www.npr.org/2025/05/22/n...

Type 2 cytokines act on enteric sensory neurons to regulate neuropeptide-driven host defense
www.science.org/doi/10.1126/...
@science.org @kuchroolab.bsky.social @thexavierlab.bsky.social

I am looking for a postdoc with an immunology background interested in joining a Yale neuroscience lab to study how the brain controls immunity. At Yale, we have a wonderful interdisciplinary & collaborative #neuroimmune community. Please reach out or share with anyone who might be interested!

It’s been fun to contribute to this work, go check the latest subtype specific enhancers from Gord’s lab!

Check out the neuroview and all the great articles of new tools to target different cell types with enhancer-mediated AAVs!

Congrats!

Today, the ERC formally adopted a decision to increase its support for researchers moving to Europe.

On top of its normal grants, the ERC offers 'start-up' funding to help PIs establish laboratories / research teams in Europe.

This extra funding is now x2 (up to €2 million!)

europa.eu/!6Vdgmp

May issue is online! Explore reviews on the #neuroimmune axis! The beautiful cover was designed by Ella Marushchenko, working with @jonykipnis.bsky.social. A brain encased in a walnut shell that is cracking open symbolizes our growing understanding of #neuroimmunology www.cell.com/immunity/iss...

A few of the incredible women representing the future of neuroimmunology #neuroimmuneGRC

Systems consolidation reorganizes hippocampal engram circuitry Nature - A study shows that loss of memory precision associated with systems consolidation can be explained by neurogenesis-dependent reorganization of engram circuitry within the hippocampus over...

Sharing a new paper from the lab. This paper, led by Sangyoon Ko, represents a merging of two longstanding research themes in the lab-- adult neurogenesis and systems consolidation.

rdcu.be/el18q

A short thread follows for those interested.

1/n

Bonsai is out! Finally, we can visually explore high-dimensional data in a distortion-free way. Try it out! It works from scRNA-seq data (bonsai.unibas.ch/bonsai-scout...) up to football statistics (bonsai.unibas.ch/bonsai-scout...). 
Ever wondered why low-dimensional embeddings like t-SNE