Jelte van der Vaart

Jelte van der Vaart, postdoc in our lab, has been awarded an NWO Veni grant! 🎉
He will develop human adrenal organoids to uncover how hormone producing cells change identity and function, shedding light on endocrine health.
We're so proud of his achievement and will support him along the way 😁

Honoured to present at the Oncode Institute Annual Meeting 2025, sharing my journey in adrenal cortex biology and organoid development from adrenocortical cancer. Grateful to the organisers for the opportunity and the inspiring discussions.

Only 2 weeks left until I run up the Alpe d’Huez for cancer research! 🏃‍♂️⛰️
Training is going strong, and I’m so close to reaching my €2500 fundraising goal.
Help me get there — and support research into rare cancers like adrenocortical cancer.

💛 Donate here: www.opgevenisgeenoptie.nl/fundraisers/...

It's World Hormone Day! 🥳

The global endocrine community is joining forces today to raise awareness of the vital role of hormones in preventing and treating disease.

Help spread the word by sharing and following #BecauseHormonesMatter

www.worldhormoneday.org

🌍 Today is #RareDiseaseDay

Adrenocortical cancer affects just 1–2 per million, making research and treatment development challenging. But rare shouldn’t mean forgotten! ACC research is key to better treatments. Let’s keep pushing forward!

#AdrenocorticalCancer #RareButImportant

📢 Organoid enthusiast: We are preparing for the 3rd edition of OrganoidNL - April 11th!
🔥 Check amazing line up of speakers 🔥
Calvin Kuo @priscaliberali.bsky.social Nicolas Rivron, Ina Sonnen @kaikretzschmar.bsky.social Mina Gouti, and others. Be fast to register in time
amolf.nl/organoidnl-s...

Center for Molecular Medicine

Our Center for Molecular Medicine (cmmutrecht.eu) at UMC Utrecht, NL, is looking for a Principal Investigator in the field of fundamental Cancer Biology! The vacancy states tenure track level, but candidates with a more advanced career are very welcome to apply. shorturl.at/KZeYQ. Please repost!

Mechanistic insights into Wnt–β-catenin pathway activation and signal transduction - Nature Reviews Molecular Cell Biology Wnt–β-catenin signalling regulates stem cell renewal, development and tissue homeostasis. In this Review, the authors examine recent findings concerning Wnt protein production, receptor activation and...

✨ New #Review ✨

@madelonmaurice.bsky.social & Stephane Angers discuss the newest insights on #WntSignalling with a focus on biogenesis & transport of Wnts and Wnt receptor complex activation.

👉 go.nature.com/42ynuU0

📣January is #AdrenalCancerAwarenessMonth
Let’s talk about #AdrenoCorticalCarcinoma to fight it together! #ACC #AdrenalCancer #CureACC #EndoSky #MedSky @amenduk.bsky.social

WNT7B drives a program for pancreatic cancer subtype switching and progression Hyperactivation of WNT signaling is a well-established hallmark of cancer. Various epithelial cancers express high levels of WNT7B and WNT10A that are not commonly expressed during tissue homeostasis,...

Pre-print Alert! 📢
Proud to share our insights on WNT7B driving pancreatic cancer progression. Sprangers et al uses organoids to show that WNT7B employs short-range signaling driving tumor growth and mediate a shift of PDAC cells towards a more aggressive phenotype

www.biorxiv.org/content/10.1...

Excited about our pre-print on AXIN1 mutations in HCC!

We found that AXIN1 mutations drive low but physiologically relevant levels of Wnt/β-catenin signaling, while being permissive to YAP/TAZ activation. This helps explain why mutations in AXIN1 and β-catenin are linked to distinct HCC subtypes.

Me

CMM starterpack Join the conversation

Scientists are fleeing Twitter and joining forces on BlueSky 🦋. Interested in seeing your (departmental) colleagues of the Center for Molecular Medicine, Utrecht? Join the CMM starter pack
go.bsky.app/N5aWHZ2

#Organoid research starter pack.
I didn't find many researchers from the field yet, please comment/text me to be added!
go.bsky.app/RmXgs6d

Happy to join this, Jens!