#proteomics_101 Compare and contrast the molecular mechanisms used to import proteins from the cytoplasm into mitochondria and the endoplasmic reticulum, including a list of at least 5 major differences between the two processes.
Doctorow also described it as such, a couple months ago. It's an apt comparison.
pivot-to-ai.com/2025/06/05/g...
Guess whose youth (18-21) population is projected to hold up better than any in the Americas over the next 20 years?
The automaker rolled out its updated Seal 07 electric sedan, replete with the second-generation Blade lithium-iron phosphate (LFP) battery and compatibility with its new 1,500 kilowatt “Flash” chargers. It has a maximum CLTC range of 705 kilometers (438 miles).
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This is exactly my gemini answer, so it is consistently an F. I was between meetings and always testing.
Gemini's answers would get you an F if I was teaching the course.
#proteomics_101 Provide 3 testable hypotheses about what makes the cward two thirds of yeast SED4:p (SED4, Integral ER membrane protein) disappear from most proteomics measurements.
It does tear the veil off the rather silly pretense that "modern" (19th century) scientific communication methods make sense in the current environment. Big, disinterested companies whose only product is access to indifferent PDF servers make nonsense of it all.
You can apparently get anything into Nature Portfolio's Scientific Reports: www.nature.com/articles/s41.... Was there any peer review or editorial checks at all? Even of the title and abstract? Safe to say I am not submitting my manuscripts there.
This one has a much more thoughtful approach to protein-protein & protein-DNA interactions, although it is not the main topic of the article.
link.springer.com/article/10.1...
It is a little too on the nose that guys how make a living doing analysis could look at something as messy as protein-protein interaction measurements & conclude that "more, faster" is the way forward.
academic.oup.com/molecular-om...
Nice article.
Review from Fia B. Larsen in @rhp-lab.bsky.social with everything you always wanted to know about proteasomal control of transcription factors (but were afraid to ask about)
Proteasomal control of transcription factors: mechanisms, regulation and dysregulation.
doi.org/10.1007/s000...
The most useless/useful skill I learned by consulting was how to turn "Ya, probably" or "No, probably not" into 25 page reports (including an executive summary).
I prefer Gibson's "Jackpot" formulation, but yeah, we do seem to be in it.
a smokescreen of "AI makes us vastly more efficient!" Those layoffs are a hedge against the current economic downturn. They are downsizing to game the next quarter's earnings numbers.
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Reliable prediction of short linear motifs in the human proteome www.biorxiv.org/cont...
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#proteomics #prot-preprint
What factors are currently preventing LLM-based methods from making its often promised significant scientific discoveries? Once it has made a few, I'll be happy to make use of them, but until then they are still in the RFK Jr category of self-promoting science kibitzers.
At least until Norway starts to sell T-bills ...
www.penguinrandomhouse.com/books/817239...
You're making the strange assumption that they don't take the same slap dash approach to the rest of their work.
I myself am not sure that the experiments are a masterpiece. More likely they're a rushed mess that they want to rush out for a quick publication. And an AI figure is entirely fitting.
Why can’t people (especially scientists) see that AI generated figures and diagrams shout out that they were AI generated and look awful? You’ve spend many months designing and performing experiments only to cover the resulting masterpiece in clear plastic like a cheap sofa.
Nope. Lys-C doesn't, either.
They are, what the kids these days refer to as "hallucinations", or what the oldsters might call "artifacts".
Truly bizarre story from @retractionwatch.com. retractionwatch.com/2026/03/03/c...
#proteomics_101 In a proteomics experiment using tryptic peptides to assign lysine acetylation, what is the special significance of acetylation assigned to peptide C-terminal lysines?
None in particular, anyone would do, although the more the merrier.
Has anyone gone to the trouble of trying to summarize the effects of PTMs on eukaryotic ribosomal function, either as a whole or at the level of large and small subunits?
