Cincinnati Children's CBDI

Advancing lifesaving therapies for myeloid malignancies. Learn More: www.cincinnatichildrens.org/professional...

Specialists in oncology, hematology, bone marrow transplantation and proton therapy join the Cancer and Blood Diseases Institute to enhance precision medicine and multidisciplinary care. Learn more: www.cincinnatichildrens.org/professional...

Replacing Microbiota Makes Aging Intestines Young Again - Research Horizons

Replacing microbiota makes aging intestines young again. Learn more: scienceblog.cincinnatichildrens.org/replacing-mi...

Cincinnati Children’s has again been named one of America’s Best Large Employers by Forbes. Of the 700 companies recognized, we ranked No. 55 nationally—which is in the top 8% across all industries.

We’re incredibly grateful to receive three grants from the Cure Starts Now Foundation. Watch the video to learn more about what this means for our work. 🎗️

Why Metabolism Matters in Fanconi Anemia - Research Horizons

New research reveals striking metabolic differences in people with Fanconi anemia (FA). These findings could reshape how clinicians approach nutrition and potentially cancer prevention. Learn more: scienceblog.cincinnatichildrens.org/why-metaboli...

www.science.org/doi/10.1126/...

Study Reveals Method to Restore ‘Exhausted’ Blood Stem Cells - Research Horizons

Discovery from our team opens doors to improve stem cell transplant outcomes and potentially healthier aging. Learn more:
scienceblog.cincinnatichildrens.org/study-reveal...

Hoxworth truck in front of Cincinnati Children's location

January is Blood Donor Month, and Hoxworth needs your help. Make an appointment at one of our drives or in the community. When you check in, mention you’re donating for “Cincinnati Children’s” because every donation saves lives, and we’re grateful for your support: www.hoxworth.org/groups/cchmc...

Holiday display at Burnet Campus

Embracing the spirit of the holidays, our annual display at Burnet Campus highlights some of the different traditions, beliefs & cultures celebrated in Dec. The display includes symbols and visual representations that honor and respect the traditions of Hanukkah, Christmas & Kwanzaa. Happy Holidays!

$1.48M State Grant Boosts ENGRAFT Learning Network - Research Horizons

Cincinnati Children’s—home to the nation’s #1 pediatric cancer program—is driving innovation in cancer care. Ohio Governor Mike DeWine announced a $1.48M state grant to strengthen the Engraft Learning Network, a collaborative effort improving outcomes for kids undergoing stem cell transplants.

Observed annually on Nov. 11, Veterans Day is an opportunity to recognize the bravery of all our U.S. Military Veterans and the sacrifices they’ve made. ♥️

A unified multimodal single-cell framework reveals a discrete state model of hematopoiesis in mice - Nature Immunology Grimes and colleagues integrate multiomic features to create a framework that allows the isolation of discrete cell states across hematopoiesis and exploit the underlying gene regulatory networks to i...

Congrats to Lee Grimes, Nathan Salomonis and colleagues @cincychildrens.bsky.social for their latest publication in #NatureImmunology shedding new light on how #BoneMarrow produces blood cells. www.nature.com/articles/s41...

Our CBDI teams had a spooktacular time celebrating Halloween today. An extra special shoutout to Susan Council, our Outpatient Clinical Manager, for 30 incredible years of service! 👏🎃

Hot New Clues for Treating Immune 'Cold' Tumors - Research Horizons

Making ‘Cold’ Tumors Sensitive Again: In mice, rapamycin re-sensitizes tumors with RAC1 A159V mutations to immune checkpoint inhibitors. Early findings offer rationale for combination therapy.
Study: www.science.org/doi/10.1126/...
Blog summary:
scienceblog.cincinnatichildrens.org/hot-new-clue...

Hot New Clues for Treating Immune 'Cold' Tumors - Research Horizons

A study led by Mingjun Cai and Yi Zheng, PhD, reveals how a tumor mutation blocks immune checkpoint inhibitors, and shows a way to make the tumors sensitive again. Learn more: scienceblog.cincinnatichildrens.org/hot-new-clue...

Rethinking How Bone Marrow Works - Research Horizons

Researchers from our team are rethinking how bone marrow works. Learn more: scienceblog.cincinnatichildrens.org/rethinking-h...

For the third year in a row, we’re honored to be ranked #1 in the nation for Pediatric Cancer Care. 🎗️💛

For the 16th year in a row, we’ve earned a spot on the Best Children’s Hospitals Honor Roll by U.S. News & World Report! We’re proud to be ranked #1 in the nation for: Pediatric Cancer Care, Gastroenterology & GI Surgery and Diabetes & Endocrinology.

We are honored to receive a $500,000 grant from Hyundai Hope On Wheels 🎗️

Kids facing cancer show us what it means to fight—and to thrive. Their stories of strength and hope remind us why awareness and research matter. This #ChildhoodCancerAwarenessMonth, we honor them and stand with every family impacted by cancer.

More:
www.cincinnatichildrens.org/service/c/ca...

Jeffersonville parents push for second opinion before 6-year-old is diagnosed with brain tumor A Jeffersonville family's persistence led to their son's life-saving brain surgery after initial misdiagnoses.

In the Spotlight: What began as a suspected stomach bug turned into a life-threatening diagnosis for 6-year-old Ronomy. After weeks of misdiagnoses, a second opinion at Cincinnati Children's revealed a brain tumor—leading to life-saving surgery.

www.whas11.com/article/news...

Four Important Things to Know About Sickle Cell Disease Sickle cell disease is the most common genetic blood disorder in the United States. It is also often misunderstood. Learn four things about sickle cell and the people it affects.

Did you know sickle cell disease is the most common severe genetic blood disorder in the U.S.? During Sickle Cell Awareness Month, learn more about this condition and the people in your community it affects: blog.cincinnatichildrens.org/rare-and-com.... #SickleCell #SickleCellAwarenessMonth

🎗️ As we begin #ChildhoodCancerAwarenessMonth, we’d like to introduce you to Harper — a brave young girl whose cancer journey reminds us of the strength and resilience children show in the face of unimaginable challenges. www.cincinnatichildrens.org/service/s/su...

Atticus the Great | Cincinnati Children's YouTube video by Cincinnati Children's

Today marks 9 years since our Proton Therapy Center opened! We've made major strides, like completing the first FLASH clinical trial. Stories like Atticus’s, who received proton therapy for brain cancer, remind us why this work is so important. Learn more: youtu.be/siC7bs7ziuE?...

HLH | Medical Stories Easton had HLH, despite being under a year old. Kayla and Eric were enjoying their time as parents until his health took a turn for the worse.

In a segment airing nationwide on @pbs.org, Dr. Michael Jordan sheds light on Hemophagocytic Lymphohistiocytosis (HLH)—a rare and life-threatening immune disorder. 💙
📺 Watch: medicalstories.tv/title/hlh/

Targeting of IRAK4 and GSPT1 enhances therapeutic efficacy in AML via c-Myc destabilization - Leukemia Leukemia - Targeting of IRAK4 and GSPT1 enhances therapeutic efficacy in AML via c-Myc destabilization

"This study demonstrates that #IRAK4 is a therapeutic target in #AML."

Congrats to Dr. Starczynowski and colleagues @cincychildrenscbdi.bsky.social #CincinnatChildrens #CincyKidsScience

www.nature.com/articles/s41...

A novel mouse model of hemoglobin SC disease reveals mechanisms underlying beneficial effects of hydroxyurea - PubMed Sickle cell hemoglobin C (HbSC) disease results from compound heterozygosity of hemoglobin S (HbS) and hemoglobin C (HbC), comprising 30% of sickle cell disease (SCD). HbC induces red blood cell (RBC)...

75 years after the discovery of HbSC type #SickleCellDisease, the field finally has a mouse model to advance care for millions of people with this disease around the world

Very proud to be a part of the @cincychildrenscbdi.bsky.social #sicklecell center

pubmed.ncbi.nlm.nih.gov/40324066/

Tune in to Cincinnati Children's Applied Gene and Cell Therapy Center "Meet the Expert Series" on Friday, July 18 from 12pm-1pm. Register here: cvent.me/BPa5o5.

Our 2024 Research Annual Report is live! Learn how experts @cincychildrens.bsky.social @cincykidsheart.bsky.social @cincykidsrad.bsky.social and more are improving #childhealth fueled by $308M in #research funding. #RAR24 #MedSky #PedsSky #SciSky scienceblog.cincinnatichildrens.org/explore-our-...

Join us for the first session of the AGCTC Forum: Meet the Expert, presented by Cincinnati Children’s Applied Gene and Cell Therapy Center. This new webinar series kicks off on Monday, June 9, 2025, from 12:00 PM to 1:00 PM EST. Register here: cvent.me/L1r815
#AGCTCForum