Enhanced virulence and stress tolerance are signatures of epidemiologically successful Shigella sonnei
@sydneylmiles.bsky.social @katholt.bsky.social
🙏to transformative collaborative effort
www.nature.com/articles/s41...
🔊 Empowering women in science means amplifying voices, breaking barriers, and driving change.
Ahead of #IWD2025, we celebrate Dr. Sydney Miles, whose career is a testament to perseverance, passion, and the power of representation in science.
🔗 bit.ly/4kwlPVl
Incredible #MicrobialGenomics research powered by MicrobesNG—highlights from our global community of researchers! 🌍🔬
@sydneylmiles.bsky.social presents 15 complete epidemiologically relevant Shigella sonnei genomes, including critical pINV invasion plasmid
www.biorxiv.org/content/10.1... #MicroSky
There are still a couple of days to apply for this PhD project. A fantastic KCL-A*STAR partnership to study bacterial persistent infections!
@vintorraca.bsky.social @oehlerslab.org
Project 4.1 of the project catalogue, page 10
Deadline to apply: 23rd February!
Finally, we infect human neutrophils and find that lineage 3 has an enhanced tolerance to phagosomal killing - together creating the perfect storm!
Read more about what we think is contributing to the epidemiological success of lineage 3 S. sonnei here: www.biorxiv.org/content/10.1...
Using a zebrafish model, we show that lineage 3 are more virulent, more likely to disseminate from the infection site and induce a stronger neutrophil response
As promised, part 2 here! 🐟
We found that isolates from the dominant lineage 3 of Shigella sonnei carry fewer genes encoding adhesins and fimbriae, but virulence-associated regions remain highly conserved - pointing towards immune evasion and host restriction
Enhanced virulence and stress tolerance are signatures of epidemiologically successful Shigella sonnei https://www.biorxiv.org/content/10.1101/2025.02.05.636615v1
Thank you to everyone who helped make this happen!
@yekwah.bsky.social @bananabenana.bsky.social @vintorraca.bsky.social @clairejenkins2.bsky.social @ksbakes.bsky.social @katholt.bsky.social @sergemostowylab.bsky.social (and FX Weill and Steve Baker who aren’t on BlueSky)
Most Shigella sonnei experimental work relies on a 70yr old lab strain that doesn’t reflect those circulating today - we are excited to share a (soon to be) publicly available set of genomes and isolates to fill that gap!
An exciting part 2 featuring our favourite fish to follow very shortly… 🐟
A public resource of 15 genomically characterised representative strains of Shigella sonnei https://www.biorxiv.org/content/10.1101/2025.02.03.635664v1
Got anyone that you would want to banish to rainy London then sweltering Singapore with a risk of giving themselves a shigella infection? Exchange program PhD Project with me and Vincenzo Torraca on page 10 #zebrafish at @astar-idlabs.bsky.social
www.kcl.ac.uk/study-legacy...
Great opportunity for prospective PhD students!
Join my lab at KCL and Stefan Oehlers lab at A*STAR to help us dissect how certain bacteria establish infections that are difficult to eradicate in vivo!
Project 4.1 of the project catalogue, page 10
Deadline to apply: 23rd February!
Certain sublineages of antimicrobial resistant bacteria dominate the surveillance landscape, but what causes them to become resistant? Check out our latest work in Shigella to find out and/or read the thread below www.medrxiv.org/content/10.1101/2024.10.27.24316207v2
1/n
Woohoo! Congrats, Dr. Miles 🎉 #PhDone
What better occasion to mark my first Bluesky post than passing my PhD viva?! 🎓
A huge huge thank you to my supervisors @sergemostowylab.bsky.social and @katholt.bsky.social and of course the examiners @jayhinton.bsky.social and Lucy Weinert for making the defense a great experience!
Exciting times! Our latest preprint is now live 🤩!
After nearly 16 yrs of running my lab, I truly believe this is one of the most significant contributions we've made. It offers fresh hypotheses about how pandemic Vibrio cholerae spreads globally. Let’s dive in!🧵..1/n
www.biorxiv.org/content/10.1...
An exciting PhD opportunity in a great collaboration between @noelresearchlab.bsky.social and my lab looking at heart infections in zebrafish. Details below. Deadline is the 13th December. www.findaphd.com/phds/project...
