Catherine Denicourt

Donate to Paul Maddox for Congress in NC 11 Paul is running for Congress because there’s a sickness in Washington, and no one is working to cure it.

Dear all, A scientist from UNC Chapel Hill, Paul Maddox, is running for congress in NC for a seat currently held by a republican. If you care about science (and democracy) please consider donating to his campaign #Standupforscience secure.actblue.com/donate/paul-...

📝 Online now - the Review "Mapping rRNA, tRNA, and mRNA modifications in ribosomes at high resolution" from Lukasz Koziej and Sebastian Glatt.

#RNAmodifications #epitranscriptomics #TranslationRegulation #CodonBias #TherapeuticTargeting

Read it here: authors.elsevier.com/a/1lnYa3S6Gf...

RNAcanvas: interactive drawing and exploration of nucleic acid structures Abstract. Two-dimensional drawing of nucleic acid structures, particularly RNA structures, is fundamental to the communication of nucleic acids research. H

🧪 #RNAsky

If you aren’t using RNAcanvas to draw your RNA structures and explore alternative structures, you are missing out! 56 citations in a year, with multiple ones in top journals like Nature, Science & Cell. Easy to use and packed with unique features! Try it!

academic.oup.com/nar/article/...

An RNA modification prevents extended codon-anticodon interactions from facilitating +1 frameshifting Nature Communications - tRNAs contain many chemical modifications that regulate their function. Integrating smFRET and cryo-EM approaches, this work demonstrates that m1G37 in tRNAProL stabilizes...

These exciting new results therefore have important implications for recoding of the genetic code for synthetic biology purposes and in the use of suppressor tRNAs for premature stop codon readthrough in human diseases. Congrats everyone!
rdcu.be/eAcLz

Ok, wow. Mine was reviewed Oct 2024 (7%ile) and no news. NIGMS should really update their funding policy page. Had I known…

Which Council was this for? Did your PO confirm it would not be funded? All my PO can say is "I have no information "

Having a 5 percentile R01 grant not being funded sucks so much. And having it falling through the cracks because of delays in council meetings and other administrative shenanigans even more.

Check out this amazing work from @genophoria.bsky.social’s lab, revealing a novel post-transcriptional tumour suppressive programme in breast cancer 👇👇

MapID-based quantitative mapping of chemical modifications and expression of human transfer RNA tRNA chemical modifications play critical roles in biology and diseases. Tepe et al. report MapID-tRNA-seq to map m1A, m3C, and multiple bulky modifications in tRNAs from HEK293T and breast cancer-rel...

Happy to share a paper from our group on "MapID-tRNA-seq" for confidently identifying modifications by RT mutation signatures in human tRNAs. This method will enable future discoveries of modifications' occurrence and functions in tRNA biology and diseases. www.cell.com/cell-chemica...

Yes, grant reviewed early February and received summary statement on March 5

An ultraconserved snoRNA-like element in long noncoding RNA CRNDE promotes ribosome biogenesis and cell proliferation Cancer cells frequently enhance ribosome production to support rapid growth. Here, Lee et al. demonstrate that an isoform of lncRNA CRNDE containing an ultraconserved element (CRNDEUCE) promotes 60S r...

It's difficult to focus on science with everything going on, but I still enjoy hearing about other people's work here, so I want to continue sharing ours. Congrats to postdoc Jong-Sun Lee for his outstanding work published in @cp-molcell.bsky.social! Details in thread👇
www.cell.com/molecular-ce...

Rpl12 is a conserved ribophagy receptor - Nature Cell Biology Chen, Hu, Zhao, Fang and colleagues show that the ribosomal large subunit protein Rpl12 functions as a conserved ribophagy receptor in multiple organisms.

☕Chen, Hu, Zhao, Fang & co show that the #ribosomal large subunit protein Rpl12 functions as a conserved #ribophagy receptor in multiple organisms.
rdcu.be/eevML
bit.ly/4hveoet

In a new Science study, cryo–electron tomography captures the in-cell architecture of the mitochondrial respiratory chain, illuminating how the coordinated action of molecular machines drives life’s fundamental energy conversion.

Learn more in this week's issue: scim.ag/3FA3Ygq

Transfer RNA acetylation regulates in vivo mammalian stress signaling An ancient tRNA modification is used by mammalian cells to coordinate protein translation and adaptive signaling.

Excited to share this one! We developed an in vivo model for specific manipulation of transfer RNA acetylation and found it serves as a sentinel modification whose loss causes ribosome stalling and stress signaling. Implications for a genetic disorder and cancer.

www.science.org/doi/10.1126/...

Congrats!

Special shout out this AM to NIH 🧪 grant mgmt specialists, POs, and SROs during this chaotic time - THANK YOU for caring for our grants and uploading scores/summary statements despite the unprecedented challenges you may be facing. You are science warriors and we APPRECIATE & SUPPORT YOU 🫶

Sign the Petition Petition to Reverse the NIH Indirect Cost Cap (NOT-OD-25-068)

Petition to Reverse the NIH Indirect Cost Cap initiated by Tom Maniatis. Please amplify
Sign the Petition: chng.it/kK2HMP5pGk
"Share with Leadership & Faculty. Reach out to professional societies, biotech and pharma leaders, and philanthropic organizations to raise awareness and mobilize support."

Also wondering about that and Advisory Council meetings. NIGMS Council is scheduled this week

Hello BlueSky! Follow us to stay up to date on the inspiring science published in our journals and more.

To get started, check out our #starterpack to meet all the Cell Press journals currently on the platform, with more to come🧪🔬🤖🧬🌳🪲

go.bsky.app/TdKYuS7

Ribosomes team up in difficult situations, new technology show - Hubrecht Institute Researchers from the Tanenbaum group have developed a new microscopy technique to observe how ribosomes function in cells.

Seeing ribosomes in action? Thanks to researchers from the @marvintanenbaum.bsky.social lab this is now possible. They created a technology to track individual ribosomes during mRNA translation. The team found that ribosomes ‘help’ each other in difficult situations www.hubrecht.eu/ribosomes-te...

Are #rRNA #modifications equal a across cell types, conditions and #disease? Are they tuned upon #antibiotics exposure? In our recent works, we find that yes and yes! Exciting times ahead!! Please see authors.elsevier.com/c/1kF253vVUP... and www.nature.com/articles/s41... Feedback very welcome!! :)

Started off this morning emailing my Senators and Congressman about the NIH and the potential damage being done by unnecessary disruptions.

They need to hear from us loud and clear. Constituents matter to them as one of the primary purposes of a politician is to get re-elected (and its their job).

TRMT1L-catalyzed m22G27 on tyrosine tRNA is required for efficient mRNA translation and cell survival under oxidative stress Hwang et al. identify TRMT1L as the elusive methyltransferase responsible for catalyzing the m22G modification at position 27 on tyrosine tRNA. TRMT1L is also crucial for maintaining acp3U and D modifications on select tRNAs, and its depletion reduces tyrosine tRNA stability, global translation efficiency, and cell survival under oxidative stress.

Thrilled to share our latest story identifying TRMT1L as the methyltransferase responsible for the deposition of m22G27 modification on tyrosine tRNAs www.cell.com/cell-reports...