laggyy

Meiotic cohesin RAD21L shapes 3D genome structure and transcription in the male germline Deletion of the meiotic subunit RAD21L alters 3D chromatin structure and transcription in the mammalian male germ line.

www.science.org/doi/full/10....

Holliday junction–ZMM protein feedback enables meiotic crossover assurance - Nature Holliday junctions maintain chromosome synapsis to enable crossover assurance in budding yeast.

Nature research paper: Holliday junction–ZMM protein feedback enables meiotic crossover assurance

go.nature.com/42JHXnV

作品における描写が明確ではなく曖昧なとき（たとえばAは死んだのか？生き延びたのか？）、それが"曖昧である"ということ自体が「曖昧にしよう」という作者の意図を明快に伝えているのだけど、流行としての「考察」的な態度は、その観点を無視しているように思える。

Sex at birth is not always random — mum’s age and genetics can play a part Families with three or more boys, for example, are more likely to have another boy than a girl as the next child.

In families with several children of the same sex, the odds of having another baby of that sex are higher than of having one of the opposite sex

go.nature.com/45caBj4

In vivo mapping of mutagenesis sensitivity of human enhancers - Nature Human enhancers contain a high density of sequence features that are required for their normal in vivo function.

www.nature.com/articles/s41...

Brain implantation of soft bioelectronics via embryonic development - Nature A soft mesh microelectrode array can seamlessly integrate in developing brains, enabling long-term, stable mapping of how single-neuron activity and population dynamics emerge and evolve during brain ...

Implantable soft bioelectronics track neural activity in the developing vertebrate brain. www.nature.com/articles/s41... #NBThighlight

with Obsidian Bases you can create embedded views that reference the current file — for example if I put my "Places" base inside Taipei I get only places I saved in Taipei

The origin of vertebrate teeth and evolution of sensory exoskeletons - Nature Re-examination of the presumed Cambrian fossil fish Anatolepis reveals previous misidentification of aglaspidid sensory structures as dentine, a vertebrate sensory tissue, showing it to be an arthropod, and shifting the origin of vertebrate hard tissues to the Middle Ordovician.

Nature research paper: The origin of vertebrate teeth and evolution of sensory exoskeletons

https://go.nature.com/4jduyKk

Screenshot of Obsidian 1.9.0 showing a base with a list of books

Introducing Bases, a new core plugin that lets you turn any set of notes into a powerful database. With Bases you can organize everything from projects to travel plans, reading lists, and more.

Bases are now available in Obsidian 1.9.0 for early access users.

Solid phase transitions as a solution to the genome folding paradox - Nature In vitro reconstitution and in vivo live-cell imaging of LHX2–EBF1–LDB1 enhancer hubs in olfactory sensory neurons reveals that these transcription factors form condensates with solid, rather than liquid, phase properties.

Nature research paper: Solid phase transitions as a solution to the genome folding paradox

https://go.nature.com/3S8gJSq

Autonomous locomotion simply with tubes as limbs, and no brain? 🎈🤖

Yes, through physical synchronization! Our article is out today in Science (@science.org)

Article: www.science.org/doi/10.1126/...

Authors: @albertocomoretto.bsky.social, H.A.H. Schomaker, J.T.B. Overvelde

More below 🧪 ⚛️
(1/6)

Chromatin loops are an ancestral hallmark of the animal regulatory genome - Nature The physical organization of the genome in non-bilaterian animals and their closest unicellular relatives is characterized; comparative analysis shows chromatin looping is a conserved feature of genome architecture and spatial genome regulation emerged early in animal evolution.

Nature research paper: Chromatin loops are an ancestral hallmark of the animal regulatory genome

https://go.nature.com/4kcNObU

Engineering mtDNA deletions by reconstituting end joining in human mitochondria Combined expression of a mitochondrially targeted endonuclease and end-joining machinery enables formation of mtDNA deletions with a broad range of heteroplasmy.

A method to generate large mitochondrial DNA deletions in human cells enables the study of their pathogenicity, which could inform future treatment strategies. www.cell.com/cell/fulltex... #NBTHighlight

Virtual cells for predictive immunotherapy - @fertiglab.bsky.social @genomescience.bsky.social go.nature.com/4jfqM3Y

Protein editing using a coordinated transposition reaction Protein engineering through the ligation of polypeptide fragments has proven enormously powerful for studying biochemical processes. In general, this strategy necessitates a final protein-folding step...

Excited to share that our protein editing method from the Muir Lab is now published in @science.org

We believe that protein transposition will enable new biochemical studies of PTMs and open up new intersections of proteins and small molecules

www.science.org/doi/10.1126/...

ウクレレ練習のなかにあるレレレ YouTube video by さなちゃんねる

ウクレレ練習配信限定公開にしました
見たい人はここのリンクからどうぞ

youtube.com/live/EuBILSU...

ゆびきりをつたえて 名取さな · ゆびきりをつたえて · Song · 2023

#nowplaying

open.spotify.com/track/018DCm...

Key process in sex-cell formation can finally be studied in vitro Activity of the purified SPO11 enzyme reconstituted in cell-free system.

An enzyme involved in meiosis can now be studied in detail

https://go.nature.com/416Fnqt

Reconstitution of SPO11-dependent double-strand break formation - Nature Reconstitution of recombinantly expressed SPO11–TOP6BL complex recapitulates its DNA cleavage function and together with structural modelling and biochemical experiments, provides insights into the regulation and mechanism of SPO11 activity.

Nature research paper: Reconstitution of SPO11-dependent double-strand break formation

https://go.nature.com/4kdj0bt

glow Fred again.., Duskus, Four Tet, Joy Anonymous, Skrillex · ten days · Song · 2024

Fred again...とFour Tetのこの曲、途中のノイズ入った様にズレる部分がとても気持ちいい
open.spotify.com/track/3i9QKR...

Opinion | Don’t Believe Him (Gift Article) Look closely at the first two weeks of Donald Trump’s second term and you’ll see something very different than what he wants you to see.

NYタイムズのエズラ・クラインが、トランプの就任直後の（度を越して最悪な）挙動を冷静に分析。ギフトにしとく

「トランプは自分の進路が分岐点を迎えることを知らないのかもしれない。彼は自分が主張するほどの権力を持っていると信じているのかもしれない。それは彼の間違いであり、大統領としての彼の運命を破滅に導く自己欺瞞である。しかし本当の脅威は、彼が私たちに、自分にはない権力を持っていると信じ込ませることだ。」

目と耳を疑うような暴挙によって、自分が強いと信じ込ませようとする態度は、実は弱さの裏返しでもある。必要なのは「信じない」こと。
www.nytimes.com/2025/02/02/o...

Signs of damage that drive protein degradation How the stress-response machinery eliminates damaged proteins.

How can stress-response machinery eliminate chemically damaged proteins to ensure continued cell function and survival?

https://go.nature.com/3WECgVv

Munch mode activated

Nexus On The Beach Roberto Musci · Tower of Silence · Song · 2016

open.spotify.com/track/6LMAeS...

what it means to be a brat :) #OffTheRecord TikTok video by Charli XCX

"brat"について、なるほどね
www.tiktok.com/@charlixcx/v...

365 Charli xcx · BRAT · Song · 2024

かっこいいですね
open.spotify.com/track/5h68So...

goodnight!

金星人のくつろぎ

ロックンロール

open.spotify.com/track/6p78Ww...