@santiagomarco.bsky.social
06.03.2026 23:20
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@santiagomarco.bsky.social
Work made with Hasitha Kaushan, @santiagomarco.bsky.social, @thinks.lol, Pjotr Prins
We introduce the TracePoint Alignment (TPA) format to efficiently store and access alignments in this representation. The TPA format is already supported by IMPG (github.com/pangenome/impg), which can work directly with the tracepoint representation for pangenome queries.
Using our adaptive tracepoint representation, we can compress ~25k human-to-human alignments from ~940 GB to ~24 GB.
If you're running out of space on your cluster every day, check this out. Make data small again!
Looking for a postdoc to build my new lab at TGen (Phoenix, AZ) focused on pangenome methods for cancer and complex disease. Full stack — from pangenome assembly and compression to association studies and somatic variant discovery. Reach out if interested! guarracinolab.github.io#join
Do you use AI? 😱
Too narrow or too shallow?
Possible thanks to the organization together with @vincenza.bsky.social, @thinks.lol, Pjotr Prins, Tamara Brock, and the host @uthsc.bsky.social.
Thanks to everyone who joined the #HackPR25 biohackathon following the @humanpangenome.bsky.social annual meeting in #Memphis. We hacked on #pangenome representation and interrogation for "laptopable" pangenome-scale analyses. Accessible #pangenomics is coming!
overflowing honesty
I may call you Dr. now, but can I continue to call you Lord as I always have?
Want to level up in #pangenomics? Join our workshop, conference & biohackathon in #Memphis, May 11-15, 2025. Connect with leading scientists, embrace genomic diversity, and contribute to cutting-edge software. Register now! pangenome.github.io/MemPanG25/ #Bioinformatics #MemPanG25
Are you curious to know how the most common human chromosomal translocations arise? Here we are!