Please share. We need mail and email to @fetterman.senate.gov asking him to retract this ridiculous statement and stand tall against this lawlessness in the funding vote. For the sake of Renee Good and Alex Pretti do not write off his vote!
I do not understand why every Democrat isnβt hammering away at the clear mental decline of the president. He couldnβt even get right the name of the country heβs trying to seize today on the biggest stage in the world. Everyone else is talking about it. Why isnβt the US?
The new CDC director is known!
As good and convincing as you would expect.
It is a great honor to have our recent paper featured by Derek Lowe in Science.
mRNA Vaccines: What's the Adjuvant? | Science | AAAS www.science.org/content/blog...
This was a massive endeavor led by first authors Diana Castano and Emily Bettini. Huge thanks to the many collaborators who made this study possible, including @victora.bsky.social, Roberto Spreafico, Norbert Pardi, @reboldilab.bsky.social and many others.
Additionally, as originally reported in our preprint, this study also characterized the signals elicited by LNPs in DCs that are important for the induction of Tfh cells as well as the type of DCs and the location of LNP uptake
Using an improved experimental approach, we also showed that the sensing of the mRNA shapes the quality of Tfh cell responses (heightened generation of IFN-Ξ³+ and IL-21+ Tfh cells) and favors more robust memory B cell and plasma cell responses, along with enhanced neutralizing antibody production.
In parallel, we found that, in a type I IFN-independent manner, signaling through IL-1R is also key for the induction of optimal GC responses to Spikevax, at least partially explaining our previous finding (www.cell.com/immunity/ful... that MyD88 is important in mRNA vaccination.
Indeed, none of the classical pattern recognition receptors (PRRs) that recognize nucleic acids in the endosome or in the cytosol are activated by Spikevax in vitro or required for GC responses in vivo. These data suggest the possibility that a less characterized PRR may sense the modified mRNA.
Our work also revealed that IRF3/IRF7 are necessary for the induction of type I IFNs and for GC responses to Spikevax, even though the upstream sensor recognizing the nucleoside-modified mRNA and leading to IFN production remains to be identified.
Among the new findings that emerged during the revision of this study is the observation that type I IFNs are crucial also for GC responses to Spikevax, one of the licensed mRNA vaccines for COVID-19.
In an earlier version of this work, also available at www.biorxiv.org/content/10.1..., we found that type I IFNs produced in response to the nucleoside-modified mRNA component act on DCs to modulate their maturation and the amplification of Tfh and GC B cell responses.
I am excited to share that our work, in which we have dissected the signals driven by the nucleoside-modified mRNA and LNP components of mRNA vaccines that regulate germinal center (GC) responses, is now published in Cell! www.cell.com/cell/fulltex...
The Locci Lab is looking for a postdoctoral researcher to investigate germinal center responses to SARS-CoV-2 in Long COVID. Reach out to me if interested!
Harvard has set an example for other higher-ed institutions - rejecting an unlawful and ham-handed attempt to stifle academic freedom, while taking steps to make sure students can benefit from an environment of intellectual inquiry, rigorous debate and mutual respect. Letβs hope others follow suit.
Last I checked it was 2025.
Cod liver oil and Vit A????
This is the first movement from Sen. Fetterman, please fill out immediately if you have been impacted. Please circulate Penn, Pitt, PSU, Temple etc @cbartman.bsky.social
I expect that most academic biomedical researchers have considered leaving the USβif only in theory for now. What a colossal mess! Our representatives need to hear this. Please amplify so they know this matters. @levin.house.gov @repscottpeters.bsky.social @schiff.senate.gov @padilla.senate.gov
Yes, this is happening. I should have received year 4 R01 funds at the end of January but didnβt. No explanation given.
Long COVID is a debilitating disease state affecting millions of people globally. Researchers outline key considerations informing design, implementation, and interpretation of trials in this growing field. @michaelpelusomd.bsky.social, et al @thelancet.bsky.social
www.thelancet.com/journals/lan...
Per an NIH source:
βDiscussions with colleagues have suggested that if the universities all come together and raise hell about the delays to funding caused by not holding meetings, that might move the needle. From every state. There are well-funded universities in red states that will be impacted.β
It was a pleasure to write a News & Views article on this very important study. @katyely.bsky.social is a rising star. Watch out for her if you have an open faculty search!!
I totally agree!
Picture of a plaque assay (purple field with clear holes) showing gorgeous poliovirus plaques
My replies are perpetually full of anti-vaxxers these days telling me about polio vaccines.
Not shockingly, most of what they are saying is wrong. Luckily, I trained with Vincent Racaniello & he taught me a few things about poliovirus.
So letβs discuss the king of the Picornaviridaeππ»
Please, add me.
