Eellan Sivanesan, MD, FASA

@hopkinsmedicine.bsky.social @michelecuratolo.bsky.social @jhu.edu @uwmedicine.bsky.social

Outstanding Grand Rounds with Dr. Michele Curatolo on human-centric molecular pain neuroscience. A rigorous, integrative framework linking pain neurobiology to clinical phenotypes and potential treatment strategies.

#PainResearch #Neuroscience #TranslationalMedicine

EXPRESS: T Cells Modulate the Development and Maintenance of Painful Paclitaxel-Induced Peripheral Neuropathy in RNU Rats - Ahmed Olalekan Bakare, Gerard Limerick, Vasudha Goel, Ratan K Banik, Lei Zh... The role of T cells in chemotherapy-induced peripheral neuropathy (CIPN) is complex and shaped by biological and experimental factors, including sex, hormonal s...

Online ahead of print in Molecular Pain:
T cells shape paclitaxel-induced neuropathic pain in a modality- and phase-specific manner, with a selective role in cold hypersensitivity.

journals.sagepub.com/doi/abs/10.1...

#CIPN

Chronic pain remains a major challenge—despite scientific progress, many patients still face delays, stigma, and limited options. I shared thoughts with @newsweek.com on why scientific advances haven’t always translated into better care.
www.newsweek.com/2025/08/22/c...
#ChronicPain #PainResearch

Trump Administration Scraps Effort to Pause Health-Research Funding The administration halted and then restarted billions in new research grants flowing from the National Institutes of Health.

UPDATE: The pause was scrapped Tuesday evening after intervention by top White House officials. www.wsj.com/politics/pol...

Fear and loathing on study section: Reviewing grant proposals while the system is burning As grants are canceled, delayed and subject to general uncertainty, participating in study sections can feel futile. But it’s more important than ever.

i wrote an essay for @thetransmitter.bsky.social about what it feels like to serve on an NIH grant review panel (study section) right now

www.thetransmitter.org/craft-and-ca...

anatomical model of human lungs

The double-edged nature of trained immunity

Trained immunity in alveolar macrophages can lead to damaging lung inflammation, confirming the importance of context in this phenomenon.
buff.ly/X51GxD5

What do you see when you stare at this grid of line segments: a series of rectangles, or a series of circles?

The way you perceive this optical illusion may tie back to the visual environment that surrounds you, a recent preprint suggests. scim.ag/4kTxbmd

You bet. @robgereau.bsky.social giving an overview of the amazingly rapid process of developing these HEAL pain research recommendations, including a nod to our colleagues at the OPPP now gone from NIH. Also describing 5 core principles to be considered in all #painresearch

Public service announcement. They are not Dire Wolves. They have 20 single letter changes in their entire genomes. I’ve done shits with more mutations.

Every time journalists write up a Colossus press release, They are making people stupider. Client journalism by a ridiculous company.

Trump Officials Freeze $1 Billion for Cornell and $790 Million for Northwestern The funding pause amid civil rights investigations into both universities sharply escalates the Trump administration’s campaign against elite colleges.

Columbia
Penn
Harvard
Princeton
Brown
and now Cornell and Northwestern

www.nytimes.com/2025/04/08/u...

ICU Doctor on the Impact of Funding Cuts YouTube video by Johns Hopkins University

#ResearchSavesLives

Shot this when I was on service a couple weeks ago

youtu.be/SkstSgeUotU

The Shingles Vaccine and Reduction of Dementia A compelling new study adds to the body of data supporting some protection provided by the vaccine

A major paper @nature.com this week found a significant decline in dementia after an outdated Shingles vaccine.
I've reviewed the study and many other relevant ones here
erictopol.substack.com/p/the-shingl...

This photograph shows a female standard fancy rat—a domesticated variant for the pet trade. That rats make good pets is not surprising when considering the long history of their close associations with humans. Although brown and black "wild" rats do spread some infectious diseases, we have recently learned about more-positive attributes, including quite how adept, adaptable, and even fun-loving they are.

A special issue of Science explores the complex and close associations rats share with humans—from their ubiquity in the human environment to their crucial role as biomedical models.

🐀 Learn more on #WorldRatDay: scim.ag/3E7Xo04